Results 21 to 30 of about 17,080,419 (148)

Targeting of the MYCN protein with small molecule c-MYC inhibitors [PDF]

, 2014
This study was funded by grants from the Swedish Research Council and the Swedish Cancer Society. IM and HZ were recipients of graduate student grants from KI (KID), MAH was recipient of a Senior Investigator Award from the Swedish Cancer Society, and ...
Edward V Prochownik, Inga Müller, Oliynyk, G, Ganna Oliynyk (568258), Zirath Hanna, Prochownik Edward V., Larsson, Karin, Anna Frenzel, Marie Arsenian Henriksson, Anna Frenzel (194997), Edward V. Prochownik (163628), Henriksson, MA, Westwood Nicholas J., Oliynyk, Ganna, Hanna Zirath, Marie Arsenian Henriksson (195006), Oliynyk Ganna, Ganna Oliynyk, Larsson, K, Frenzel, A, Frenzel, Anna, Zirath, Hanna, Prochownik, Edward V., Nicholas J Westwood, Frenzel Anna, Zirath, H, Henriksson Marie Arsenian, Karin Larsson, Muller, Inga, Nicholas J. Westwood, Inga Müller (568256), Nicholas J. Westwood (254891), Edward V. Prochownik, Müller, I, Westwood, NJ, Müller Inga, Henriksson, Marie Arsenian, Karin Larsson (568257), Hanna Zirath (195000), Prochownik, EV, Westwood, Nicholas J., Larsson Karin, Oliynyk, G,, Larsson, K,   +43 more
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The effect of oxidation on the stability of G-quadruplex DNA : implications for oncogene expression [PDF]

, 2011
G-quadruplexes (G4-DNA) are a class of secondary structures formed from Guanine rich sequences. In recent years these structures have been implicated in both telomere maintenance and oncogene expression, and have been shown to be abundant in upstream ...
Stebbeds, William Joshua David
core   +2 more sources

Notch: From fly wings to human hematological tumors [PDF]

Archive of Oncology, 2009
Notch history begins in 1919 with Thomas Hunt Morgan studies on fruit fly mutants. From then, this gene aroused lively interest in the scientific community since it is involved in a wide variety of processes, including morphogenesis, tissue homeostasis ...
Mirandola Leonardo, Larocca Sara, Rea Katia, Palma Giovanni, Comi Paola, Chiaramonte Raffaella   +5 more
doaj   +1 more source

Functional Role and Therapeutic Potential of the Pim-1 Kinase in Colon Carcinoma

Neoplasia: An International Journal for Oncology Research, 2013
PURPOSE: The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase is overexpressed in various tumors and has been linked to poor prognosis.
Ulrike Weirauch, Nadine Beckmann, Maren Thomas, Arnold Grünweller, Kilian Huber, Franz Bracher, Roland K. Hartmann, Achim Aigner   +7 more
doaj   +3 more sources

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2 [PDF]

, 1996
The Ras oncogene products regulate the expression of genes in transformed cells, and members of the Ets family of transcription factors have been implicated in this process.
Yang, Beom-Seok, Ostrowski, M C, Hauser, C A, Hauser, Craig A., Van Beveren, Charles, Maki, R A, Yang, B S, Henkel, G, Hume, D A, Ostrowski, Michael C., Colman, M S, Colman, Michael S., Van Beveren, C, Henkel, Gregory, Stacey, K J, Hume, David A., Maki, Richard A., Stacey, Katryn J.   +17 more
core   +1 more source

PIM1-dependent phosphorylation of Histone H3 at Serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. [PDF]

, 2007
The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive.
Salvatore Oliviero, Serafini, Riccardo, Riccardo Serafini, Alessandra De Robertis, Alessio Zippo, De Robertis, Alessandra, Zippo, Alessio, Oliviero, Salvatore   +7 more
core   +1 more source

Molecular and functional characterization of the interaction between c-Myc and the MCM helicase [PDF]

, 2006
The Myc genes (c-myc, n-myc, l-myc, s-myc) encode a family of protein that share structural an biological features and are conserved across all Metazoans.
Ruggiero, Luca
core   +1 more source

Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis [PDF]

, 2004
Background Tumour regression observed in many conditional mouse models following oncogene inactivation provides the impetus to develop, and a platform to preclinically evaluate, novel therapeutics to inactivate specific oncogenes.
Abouna, Sylvie, Cheung, Linda, Zervou, Sevasti I., Khan, Michael, Stella Pelengaris, Sylvie Abouna, Sevasti Zervou, Michael Khan, Linda Cheung, Ifandi, Vasiliki, Pelengaris, Stella, Vasiliki Ifandi   +11 more
core   +1 more source

Deciphering c-MYC-regulated genes in two distinct tissues [PDF]

, 2011
Background: The transcription factor MYC is a critical regulator of diverse cellular processes, including both replication and apoptosis. Differences in MYC-regulated gene expression responsible for such opposing outcomes in vivo remain obscure.
Lesley Ward, Heather Turner, Michael Khan, Ward, Lesley (Lesley A.), Brown, Helen, Turner, Heather, Helen Brown, Hunter, Ewan, Ward, Lesley, Khan, Michael, Samuel C Robson, Stella Pelengaris, Brown, Helen (Helen E.), Robson, Samuel C, Robson, Samuel Charles, Pelengaris, Stella, Ewan Hunter, Turner Heather, Hunter Ewan, Pelengaris Stella, Ward Lesley, Khan Michael, Brown Helen, Robson Samuel C   +23 more
core   +5 more sources

N-Myc Differentially Regulates Expression of MXI1 Isoforms in Neuroblastoma

Neoplasia: An International Journal for Oncology Research, 2013
Amplification of the MYCN proto-oncogene is associated with a poor prognosis in patients with metastatic neuroblastoma (NB). MYCN encodes the N-Myc protein, a transcriptional regulator that dimerizes with the Max transcription factor, binds to E-box DNA ...
Michael B. Armstrong, Rajen J. Mody, D. Christian Ellis, Adam B. Hill, David A. Erichsen, Daniel S. Wechsler   +5 more
doaj   +1 more source