Results 21 to 30 of about 79,488 (241)

Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic polyadenylation element-binding protein CPEB [PDF]

Oncogene, 2012
The regulation of mRNA deadenylation constitutes a pivotal mechanism of the post-transcriptional control of gene expression. Here we show that the antiproliferative protein Tob, a component of the Caf1-Ccr4 deadenylase complex, is involved in regulating the expression of the proto-oncogene c-myc.
K, Ogami, N, Hosoda, Y, Funakoshi, S, Hoshino   +3 more
openaire   +2 more sources

Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner

Cell Death and Disease, 2021
Increased reactive oxygen species levels in the mitochondrial matrix can induce Parkin-dependent mitophagy, which selectively degrades dysfunctional mitochondria via the autolysosome pathway. Phosphorylated mitofusin-2 (MFN2), a receptor of parkin RBR E3
Cheng Zhang, Pengqing Nie, Chunliu Zhou, Yue Hu, Suling Duan, Meijia Gu, Dongxu Jiang, Yunfu Wang, Zixin Deng, Jincao Chen, Shi Chen, Lianrong Wang   +11 more
doaj   +1 more source

Cellular reprogramming with multigene activation by the delivery of CRISPR/dCas9 ribonucleoproteins via magnetic peptide-imprinted chitosan nanoparticles

Materials Today Bio, 2021
Induced pluripotent stem cells are usually derived by reprogramming transcription factors (OSKM), such as octamer-binding transcription factor 4 (OCT4), (sex determining region Y)-box 2 (SOX2), Krüppel-like factor 4 (KLF4), and cellular proto-oncogene (c-
Mei-Hwa Lee, Cheng-Chih Lin, James L. Thomas, Jin-An Li, Hung-Yin Lin   +4 more
doaj   +1 more source

The deazaguanine‐derivative, queuine, affects cell proliferation, protein phosphorylation and the expression of the proto oncogenes c‐fos and c‐myc in HeLa cells [PDF]

FEBS Letters, 1990
In higher eukaryotes the hypermodified guanine analogue, queuine (7‐(5‐(((1S,4S,5R)‐4,5‐dihydroxy‐2‐cyclopentene‐1‐yl)amino)‐methyl)‐7‐deazaguanine), occurs free or as modified nucleoside (Q) in the anticodon of specific tRNAs. Fast proliferating tissues and tumors contain considerable amounts of free queuine and Q‐deficient tRNAs.
Langgut, W., Kersten, H.
openaire   +2 more sources

Hexachlorobenzene-Induced Early Changes in Ornithine Decarboxylase and Protein Tyrosine Kinase Activities, Polyamines and c-Myc, c-Fos and c-Jun Proto-Oncogenes in Rat Liver [PDF]

Toxicological Sciences, 2003
El hexaclorobenceno (HCB) es un compuesto químico lipófilo que se distribuye ampliamente en el medio ambiente. Se sabe que el HCB causa tumores hepáticos en animales de experimentación. En el presente estudio se investigó el efecto in vivo del tratamiento con HCB sobre las actividades de la ornitina descarboxilasa (ODC) y la proteína tirosina quinasa ...
Andrea S, Randi, Susana, Hernandez, Laura, Alvarez, Marcela, Sanchez, Marta, Schwarcz, Diana L, Kleiman d Pisarev   +5 more
openaire   +2 more sources

Maf1, a new player in the regulation of human RNA polymerase III transcription. [PDF]

PLoS ONE, 2006
Human RNA polymerase III (pol III) transcription is regulated by several factors, including the tumor suppressors P53 and Rb, and the proto-oncogene c-Myc.
Jaime H Reina, Teldja N Azzouz, Nouria Hernandez   +2 more
doaj   +1 more source

Heat Shock Protein 90α–Dependent B‐Cell‐2–Associated Transcription Factor 1 Promotes Hepatocellular Carcinoma Proliferation by Regulating MYC Proto‐Oncogene c‐MYC mRNA Stability [PDF]

Hepatology, 2018
B‐cell lymphoma 2 (Bcl‐2)‐associated transcription factor 1 (Bclaf1) is known to be involved in diverse biological processes, but, to date, there has been no evidence for any functional role of Bclaf1 in hepatocellular carcinoma (HCC) progression.
Zhou, Xueqiong, Wen, Ying, Tian, Ye, He, Meiling, Ke, Xiangyu, Huang, Zhizhou, He, Yangfan, Liu, Lixia, Scharf, Annette, Lu, Meiting, Zhang, Guowei, Deng, Yaotang, Yan, Yuxia, Mayer, Matthias P., Chen, Xuemei, Zou, Fei   +15 more
openaire   +2 more sources

Amino Acid Transporters as Potential Therapeutic Targets in Thyroid Cancer [PDF]

Endocrinology and Metabolism, 2020
Thyroid cancer cells have a high amino acid demand for proliferation, invasion, and metastasis. Amino acids are taken up by thyroid cancer cells, both thyroid follicular cell and thyroid parafollicular cells (commonly called “C-cells”), via amino acid ...
Keisuke Enomoto, Muneki Hotomi
doaj   +1 more source

Long non-coding RNA PVT1 (PVT1) affects the expression of CCND1 and promotes doxorubicin resistance in osteosarcoma cells

Journal of Bone Oncology, 2023
Background: Acquired drug-resistance is the major risk factor for poor prognosis and short-term survival in patients with osteosarcoma (OS). Accumulating evidence has revealed that long noncoding RNAs (lncRNAs), including plasmacytoma variant ...
Zi Li, Jia-Ming Tian, Yi Chu, Hong-Yi Zhu, Jun-Jie Wang, Jun Huang   +5 more
doaj   +1 more source

Targeting of the MYCN protein with small molecule c-MYC inhibitors [PDF]

, 2014
This study was funded by grants from the Swedish Research Council and the Swedish Cancer Society. IM and HZ were recipients of graduate student grants from KI (KID), MAH was recipient of a Senior Investigator Award from the Swedish Cancer Society, and ...
Edward V Prochownik, Inga Müller, Oliynyk, G, Ganna Oliynyk (568258), Zirath Hanna, Prochownik Edward V., Larsson, Karin, Anna Frenzel, Marie Arsenian Henriksson, Anna Frenzel (194997), Edward V. Prochownik (163628), Henriksson, MA, Westwood Nicholas J., Oliynyk, Ganna, Hanna Zirath, Marie Arsenian Henriksson (195006), Oliynyk Ganna, Ganna Oliynyk, Larsson, K, Frenzel, A, Frenzel, Anna, Zirath, Hanna, Prochownik, Edward V., Nicholas J Westwood, Frenzel Anna, Zirath, H, Henriksson Marie Arsenian, Karin Larsson, Muller, Inga, Nicholas J. Westwood, Inga Müller (568256), Nicholas J. Westwood (254891), Edward V. Prochownik, Müller, I, Westwood, NJ, Müller Inga, Henriksson, Marie Arsenian, Karin Larsson (568257), Hanna Zirath (195000), Prochownik, EV, Westwood, Nicholas J., Larsson Karin   +41 more
core   +1 more source