Results 11 to 20 of about 79,488 (241)

The protein encoded by the human proto-oncogene c-myc. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1984
The proto-oncogene c-myc may play a role in controlling the growth and division of normal cells, and abnormalities of the gene have been implicated in the genesis of a substantial variety of human tumors. To facilitate further study of these issues, we developed antisera that permit the identification and isolation of the protein encoded by the human ...
G I Evan
exaly   +3 more sources

Hinge like domain motion facilitates human RBMS1 protein binding to proto-oncogene c-myc promoter [PDF]

Nucleic Acids Research, 2021
Abstract DNA binding proteins recognize DNA specifically or non-specifically using direct and indirect readout mechanisms like sliding, hopping, and diffusion. However, a common difficulty in explicitly elucidating any particular mechanism of site-specific DNA-protein recognition is the lack of knowledge regarding target sequences and ...
Priyanka Aggarwal, Neel Sarovar Bhavesh
openaire   +2 more sources

Polydatin Inhibits Cell Viability, Migration, and Invasion Through Suppressing the c-Myc Expression in Human Cervical Cancer

Frontiers in Cell and Developmental Biology, 2021
Polydatin, an active ingredient from the roots of Polygonum cuspidatum, is considered to have protective effects on the cardiovascular system and liver.
Longchang Bai, Longchang Bai, Longchang Bai, Yingkang Ma, Yingkang Ma, Yingkang Ma, Xue Wang, Qiongni Feng, Qiongni Feng, Zhining Zhang, Zhining Zhang, Zhining Zhang, Sijie Wang, Sijie Wang, Sijie Wang, Huijie Zhang, Huijie Zhang, Huijie Zhang, Xinyu Lu, Xinyu Lu, Xinyu Lu, Yonghui Xu, Erhu Zhao, Erhu Zhao, Erhu Zhao, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui   +28 more
doaj   +1 more source

Transcriptional activation of c-myc proto-oncogene by WT1 protein [PDF]

Oncogene, 2004
The Wilms' tumor 1 gene (WT1) plays an essential role in urogenital development and malignancy. Through DNA binding, WT1 can either enhance or repress transcription depending on the context of the DNA-binding sites or the cell type in which it is expressed.
Youqi, Han, Serban, San-Marina, Jian, Liu, Mark D, Minden   +3 more
openaire   +2 more sources

MYC regulates metabolism through vesicular transfer of glycolytic kinases

Open Biology, 2021
Amplification of the proto-oncogene MYCN is a key molecular aberration in high-risk neuroblastoma and predictive of poor outcome in this childhood malignancy. We investigated the role of MYCN in regulating the protein cargo of extracellular vesicles (EVs)
Alexia Tsakaneli, Victor Corasolla Carregari, Martina Morini, Alessandra Eva, Giuliana Cangemi, Olesya Chayka, Evgeny Makarov, Sandra Bibbò, Emily Capone, Gianluca Sala, Vincenzo De Laurenzi, Evon Poon, Louis Chesler, Luisa Pieroni, Martin R. Larsen, Giuseppe Palmisano, Arturo Sala   +16 more
doaj   +1 more source

c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype. [PDF]

PLoS ONE, 2013
The proto-oncogene c-Myc is vital for vascular development and promotes tumor angiogenesis, but the mechanisms by which it controls blood vessel growth remain unclear. In the present work we investigated the effects of c-Myc knockdown in endothelial cell
Victoria Florea, Nithya Bhagavatula, Gordana Simovic, Francisco Y Macedo, Ricardo A Fock, Claudia O Rodrigues   +5 more
doaj   +1 more source

The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene [PDF]

Proceedings of the National Academy of Sciences, 2008
Parafibromin is a tumor suppressor protein encoded by HRPT2 , a gene recently implicated in the hereditary hyperparathyroidism–jaw tumor syndrome, parathyroid cancer, and a subset of kindreds with familial isolated hyperparathyroidism.
Ling, Lin, Jian-Hua, Zhang, Leelamma M, Panicker, William F, Simonds   +3 more
openaire   +2 more sources

High Intrinsic Oncogenic Potential in the Myc-Box-Deficient Hydra Myc3 Protein

Cells, 2023
The proto-oncogene myc has been intensively studied primarily in vertebrate cell culture systems. Myc transcription factors control fundamental cellular processes such as cell proliferation, cell cycle control and stem cell maintenance.
Marion Lechable, Xuechen Tang, Stefan Siebert, Angelika Feldbacher, Monica L. Fernández-Quintero, Kathrin Breuker, Celina E. Juliano, Klaus R. Liedl, Bert Hobmayer, Markus Hartl   +9 more
doaj   +1 more source

Toxoplasma Uses GRA16 To Upregulate Host c-Myc

mSphere, 2020
Manipulation of the host cell is a crucial part of life for many intracellular organisms. We have recently come to appreciate the extent to which the intracellular pathogen Toxoplasma gondii reprograms its host cell, and this is illustrated by the marked
Michael W. Panas, John C. Boothroyd
doaj   +1 more source

Integration of genome and chromatin structure with gene expression profiles to predict c-MYC recognition site binding and function. [PDF]

PLoS Computational Biology, 2007
The MYC genes encode nuclear sequence specific-binding DNA-binding proteins that are pleiotropic regulators of cellular function, and the c-MYC proto-oncogene is deregulated and/or mutated in most human cancers. Experimental studies of MYC binding to the
Yili Chen, Thomas W Blackwell, Ji Chen, Jing Gao, Angel W Lee, David J States   +5 more
doaj   +1 more source