BMC Cancer, 2008 Background The three far-upstream element (FUSE) binding proteins (FBP1, FBP2, and FBP3) belong to an ancient family of single-stranded DNA binding proteins which are required for proper regulation of the c-myc proto-oncogene.
Meyer Hellmuth-Alexander +10 more
doaj +1 more source
Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2 [PDF]
, 1996 The Ras oncogene products regulate the expression of genes in transformed cells, and members of the Ets family of transcription factors have been implicated in this process.
Yang, Beom-Seok +17 more
core +1 more source
Deciphering c-MYC-regulated genes in two distinct tissues [PDF]
, 2011 Background: The transcription factor MYC is a critical regulator of diverse cellular processes, including both replication and apoptosis. Differences in MYC-regulated gene expression responsible for such opposing outcomes in vivo remain obscure.
Lesley Ward +16 more
core +1 more source
An in silico study of the differential effect of oxidation on two biologically relevant G-quadruplexes: Possible implications in oncogene expression [PDF]
, 2012 G-quadruplex structures, formed from guanine rich sequences, have previously been shown to be involved in various physiological processes including cancer-related gene expression.
William J D Stebbeds +14 more
core +1 more source
Physiological roles of the oncoprotein c-Myc in mouse mammary gland development [PDF]
, 2009 c-Myc, a transcription factor that affects a large number of target genes, is one of the most frequently deregulated oncoproteins in human cancer. The wide-ranging biological functions of c-Myc include regulation of the cell cycle, differentiation ...
Stölzle, Tina
core +1 more source
MYC is a metastasis gene for non-small-cell lung cancer. [PDF]
, 2009 Metastasis is a process by which cancer cells learn to form satellite tumors in distant organs and represents the principle cause of death of patients with solid tumors. NSCLC is the most lethal human cancer due to its high rate of metastasis.
Christian Korn +26 more
core +1 more source
The role of the proto-oncogene Ski in cortical development [PDF]
, 2013 The proto-oncogene Ski is an evolutionary conserved protein associated with various cellular processes such as proliferation and differentiation as well as transformation and tumor progression.
Baranek, Constanze Katharina Charlotte
core +1 more source
Direct Regulation of Hsp60 Expression by C-Myc Induces Transformation
, 2009 The c-MYC proto-oncogene encodes a ubiquitous transcription factor involved in cell proliferation and tumorigenesis. Heat shock protein 60 ( HSP60) plays an essential role in assisting many newly synthesized proteins to reach their native forms ...
鄧述諄;吳國瑞 +1 more
core +2 more sources
Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]
, 2002 Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G. +5 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source