Results 31 to 40 of about 17,080,419 (148)

Proteomic profiling of oleamide-mediated polarization in a primary human monocyte-derived tumor-associated macrophages (TAMs) model: a functional analysis [PDF]

PeerJ
Background Tumor-associated macrophages (TAMs) play a critical function in the development of tumors and are associated with protumor M2 phenotypes. Shifting TAMs towards antitumor M1 phenotypes holds promise for tumor immunotherapy.
Prapakorn Wisitpongpun, Watunyoo Buakaew, Sutatip Pongcharoen, Napaporn Apiratmateekul, Pachuen Potup, Krai Daowtak, Sucheewin Krobthong, Yodying Yingchutrakul, Paul J. Brindley, Kanchana Usuwanthim   +9 more
doaj   +2 more sources

An in silico study of the differential effect of oxidation on two biologically relevant G-quadruplexes: Possible implications in oncogene expression [PDF]

, 2012
G-quadruplex structures, formed from guanine rich sequences, have previously been shown to be involved in various physiological processes including cancer-related gene expression.
William J D Stebbeds, Lee D. Larcombe, William J. D. Stebbeds, Larcombe, Lee, Lunec Joseph, Larcombe, LD, Stebbeds, WJ, Larcombe, L. D., Stebbeds William J. D., Larcombe Lee D., Lunec, J, Lunec, Joseph, Stebbeds, William Joshua David, Lee D Larcombe, Joseph Lunec   +14 more
core   +2 more sources

Physiological roles of the oncoprotein c-Myc in mouse mammary gland development [PDF]

, 2009
c-Myc, a transcription factor that affects a large number of target genes, is one of the most frequently deregulated oncoproteins in human cancer. The wide-ranging biological functions of c-Myc include regulation of the cell cycle, differentiation ...
Stölzle, Tina
core   +1 more source

Canonical Wnt pathway gene expression and their clinical correlation in oral squamous cell carcinoma

Indian Journal of Dental Research, 2018
Aim: The aim of this study is to explore the prognostic significance and clinicopathological correlations of the Wnt pathway genes in a cohort of surgically treated patients with oral squamous cell carcinoma (OSCC) patients.
Madhulaxmi Marimuthu, Manoharan Andiappan, Abdul Wahab, M R Muthusekhar, Anandan Balakrishnan, Sambandham Shanmugam   +5 more
doaj   +1 more source

The role of the proto-oncogene Ski in cortical development [PDF]

, 2013
The proto-oncogene Ski is an evolutionary conserved protein associated with various cellular processes such as proliferation and differentiation as well as transformation and tumor progression.
Baranek, Constanze Katharina Charlotte
core   +1 more source

CEMIP promotes gefitinib resistance in lung cancer with EGFR-mutation possibly through forming a stable complex CEMIP/c-MYC

BBA Advances
While gefitinib greatly improves the prognosis of lung cancer patients with epidermal growth factor receptor (EGFR) mutation, its inevitable resistance severely diminishes therapeutic efficacy.
Li Li, Jiaxiu Xie, Jinxing Liang, Hua Su, Xiaoju Shen, Xiaoxiang Mo, Xinli Lin, Weidan Tan, Kun Wu, Fucui Zhu, Li Wang, Ying Liu   +11 more
doaj   +1 more source

Prevalence of c-myc expression in breast lesions associated with microcalcifications detected by routine mammography

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Genetic abnormalities in cell proliferation-regulating genes have been described in premalignant lesions. The aims here were to evaluate c-myc protein expression in non-palpable breast lesions associated with microcalcifications ...
Renato Coimbra Mazzini, Simone Elias, Afonso Celso Pinto Nazário, Cláudio Kemp, Ângela Flávia Logullo   +4 more
doaj   +1 more source

Molecular cloning and analysis of Myc modulator 1 (Mm-1) from Bufo gargarizans (Amphibia: Anura)

Zoologia (Curitiba), 2010
The protein of Myc modulator 1 (Mm-1) has been reported to repress the transcriptional activity of the proto-oncogene c-Myc in humans. Moreover, it was shown to be the subunit 5 of human prefoldin (PFD).
Ning Wang, Rui Jia, Jing J. Wang, Liu W. Nie   +3 more
doaj   +1 more source

MYC is a metastasis gene for non-small-cell lung cancer. [PDF]

, 2009
Metastasis is a process by which cancer cells learn to form satellite tumors in distant organs and represents the principle cause of death of patients with solid tumors. NSCLC is the most lethal human cancer due to its high rate of metastasis.
Christian Korn, Emanuele Zanucco, Potapenko, Tamara, Korn, C., Zanucco, E., Castro, I., Inês Castro, Fatih Ceteci, Potapenko, T., Ceteci, F., Rapp, Ulf R., Luetkenhaus, Katharina, Ulf R Rapp, Korn, Christian, Tamara Potapenko, Serafin, V., Christiaan Karreman, Castro, Inês, Luetkenhaus, K., Ceteci, Fatih, Zanucco, Emanuele, Valentina Serafin, Karreman, Christiaan, Karreman, C., Serafin, Valentina, Katharina Luetkenhaus, Rapp, U. R.   +26 more
core   +2 more sources

JNK and ERK8 as downstream effectors of receptor tyrosine kinases [PDF]

, 2006
MAP kinases are a super-family of serine-threonine protein kinases expressed in all eukaryotic cells. In mammals, there are many MAP kinases with different biological functions, grouped in distinctly regulated groups, ERK1/2 (extracellular signal related
Iavarone, Carlo
core   +1 more source