Detection of amplified DNA sequences by reverse chromosome painting using genomic tumor DNA as probe [PDF]
, 1993 A modification of reverse chromosome painting was carried out using genomic DNA from tumor cells as a complex probe for chromosomal in situ suppression hybridization to normal metaphase chromsome spreads.
Speicher, Michael R. +5 more
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c-erbB-2 expression in benign and malignant breast disease. [PDF]
, 1988 An antibody, 21N, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunocytochemically in a retrospective study of formalin fixed paraffin embedded breast biopsies.
Gusterson, BA +17 more
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Proto-oncogene c-jun expression is induced by AML1-ETO in a JNK dependent manner:possible role in the pathogenesis of acute myeloid leukemia [PDF]
, 2003 Overexpression of proto-oncogene c-jun and constitutive activation of the Jun NH2-terminal kinase (JNK) signaling pathway have been implicated in the leukemic transformation process.
Elsaesser, Annika
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, 2012 A given tumor is usually dependent on the oncogene that is activated in the respective tumor entity. This phenomenon called oncogene addiction provides the rationale for attempts to target oncogene products in a therapeutic manner, be it by small ...
Lehmann, FM;Feicht, S;Helm, F;Maurberger, A;Ladinig, C;Zimber-Strobl, U;Kuhn, R;Mautner, J;Gerbitz, A;Bornkamm, GW
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Expression of c-myc proto-oncogene in normal human intestinal epithelium.
, 1989 We studied the expression of the human c-myc proto-oncogene in normal human colon epithelium by both in situ hybridization and immunohistochemistry. c-myc was found to be expressed uniformly throughout the entire thickness of the colon epithelium.
J ten Kate +3 more
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Life or cell death: identifying c-Myc regulated genes in two distinct tissues [PDF]
The c-myc oncogene is over-expressed or deregulated in many human cancers. c-myc encodes a transcription factor, the oncoprotein c-Myc (Myc), which acts as a master regulator of genes involved in such diverse cellular processes as replication and growth,
Robson, Samuel Charles
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Gene Expression in Neuroblastoma [PDF]
, 1996 The aim of this project is to identify potential target genes (NTG's) which may be regulated by in the cell line SK-N-SH which has no amplification of theoncogene N-myc.
Said, Sohair S.S.
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Alternative translation of the proto-oncogene c-myc by an internal ribosome entry site
, 1997 The human proto-oncogene c-myc encodes two proteins, c-Myc1 and c-Myc2, from two initiation codons, CUG and AUG, respectively. It is also transcribed from four alternative promoters (P0, P1, P2, and P3), giving rise to different RNA 5'-leader sequences ...
Nanbru, Cécile +6 more
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c-Myc induced changes in higher order rDNA structure accompany growth factor stimulation of quiescent cells [PDF]
, 2007 Human c-Myc is believed to be a high level coordinator of protein synthesis capacity and cell growth rate, capable of activating transcription by all three nuclear RNA Polymerases.
Rachel G. Berkson +2 more
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The receptor tyrosine kinase RET is a Hsp90 client protein and is degraded upon exposure to 17-AAG. [PDF]
, 2009 Molecular alterations of the receptor tyrosin kinase RET are involved in the pathogenesis of thyroid cancer. Germline point mutations in the extracellular and intracellular domains of the receptor are responsible of a group of inherited cancer diseases ...
Alfano, Luigi
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