Results 11 to 20 of about 1,721,302 (204)
Transcriptional regulation of the human c-myc gene. [PDF]
The British journal of cancer. Supplement, 1988 The involvement of c-myc in the genesis of animal neoplasia is now well documented for several systems. In order to define the precise role played by the myc gene in tumorigenesis, a better understanding of the normal regulation of myc expression is necessary. We have begun a study of the cis-acting regulatory sequences within the 5' flanking domain of
Lang, J C +3 more
openaire +4 more sources
Gene Transactivation and Transrepression in MYC-Driven Cancers [PDF]
International Journal of Molecular Sciences, 2021 MYC is a proto-oncogene regulating a large number of genes involved in a plethora of cellular functions. Its deregulation results in activation of MYC gene expression and/or an increase in MYC protein stability. MYC overexpression is a hallmark of malignant growth, inducing self-renewal of stem cells and blocking senescence and cell differentiation ...
Scafuro M. +4 more
openaire +3 more sources
Deciphering c-MYC-regulated genes in two distinct tissues [PDF]
, 2011 Background: The transcription factor MYC is a critical regulator of diverse cellular processes, including both replication and apoptosis. Differences in MYC-regulated gene expression responsible for such opposing outcomes in vivo remain obscure.
Lesley Ward +23 more
core +5 more sources
PIM1-dependent phosphorylation of Histone H3 at Serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. [PDF]
, 2007 The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive.
Salvatore Oliviero +7 more
core +1 more source
PLoS Genetics, 2023 The molecular circadian clock, which controls rhythmic 24-hour oscillation of genes, proteins, and metabolites in healthy tissues, is disrupted across many human cancers. Deregulated expression of the MYC oncoprotein has been shown to alter expression of
Juliana Cazarin +12 more
doaj +1 more source
Methylation of plasmacytoma c-myc genes [PDF]
Gene, 1985 The chromosomal translocation associated with many tumors of immunoglobulin-producing cells frequently results in the joining of the immunoglobulin heavy-chain locus and the c-myc oncogene. This translocation of c-myc has profound structural and functional consequences for the oncogene, including loss of the 5' end of the gene and transcriptional ...
Dunnick, Wesley A. +4 more
openaire +3 more sources
Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells. [PDF]
PLoS ONE, 2008 Embryonic stem (ES) cell pluripotency is regulated in part by transcription factor (TF) pathways that maintain self-renewal and inhibit differentiation. Stat3 and c-Myc TFs are essential for maintaining mouse ES cell self-renewal.
Benjamin L Kidder +2 more
doaj +1 more source
Molecular and functional characterization of the interaction between c-Myc and the MCM helicase [PDF]
, 2006 The Myc genes (c-myc, n-myc, l-myc, s-myc) encode a family of protein that share structural an biological features and are conserved across all Metazoans.
Ruggiero, Luca
core +2 more sources
Physiological roles of the oncoprotein c-Myc in mouse mammary gland development [PDF]
, 2009 c-Myc, a transcription factor that affects a large number of target genes, is one of the most frequently deregulated oncoproteins in human cancer. The wide-ranging biological functions of c-Myc include regulation of the cell cycle, differentiation ...
Stölzle, Tina
core +1 more source
Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation
Cell Communication and Signaling, 2019 Background While regulated WNT activity is required for normal development and stem cell maintenance, mutations that lead to constitutive activation of the WNT pathway cause cellular transformation and drive colorectal cancer.
Yi-Heng Hao +9 more
doaj +1 more source