Results 11 to 20 of about 239,792 (215)
Conservation of the c-myc coding sequence in transduced feline v-myc genes
Virology, 1986 We have cloned the normal feline c-myc locus and determined the nucleotide sequence of all three exons. The feline c-myc gene shows close homology to other mammalian c-myc genes, particularly human c-myc.
Stewart, Monica A. +5 more
core +3 more sources
Gene Transactivation and Transrepression in MYC-Driven Cancers [PDF]
International Journal of Molecular Sciences, 2021 MYC is a proto-oncogene regulating a large number of genes involved in a plethora of cellular functions. Its deregulation results in activation of MYC gene expression and/or an increase in MYC protein stability. MYC overexpression is a hallmark of malignant growth, inducing self-renewal of stem cells and blocking senescence and cell differentiation ...
Scafuro M. +4 more
openaire +3 more sources
An alternative pathway for gene regulation by Myc [PDF]
The EMBO Journal, 1997 The c-Myc protein activates transcription as part of a heteromeric complex with Max. However, Myc-transformed cells are characterized by loss of expression of several genes, suggesting that Myc may also repress gene expression. Two-hybrid cloning identifies a novel POZ domain Zn finger protein (Miz-1; Myc-interacting Zn finger protein-1) that ...
Peukert, K +5 more
openaire +3 more sources
Deciphering c-MYC-regulated genes in two distinct tissues [PDF]
, 2011 Background: The transcription factor MYC is a critical regulator of diverse cellular processes, including both replication and apoptosis. Differences in MYC-regulated gene expression responsible for such opposing outcomes in vivo remain obscure.
Lesley Ward +16 more
core +1 more source
PLoS Genetics, 2023 The molecular circadian clock, which controls rhythmic 24-hour oscillation of genes, proteins, and metabolites in healthy tissues, is disrupted across many human cancers. Deregulated expression of the MYC oncoprotein has been shown to alter expression of
Juliana Cazarin +12 more
doaj +1 more source
Methylation of plasmacytoma c-myc genes [PDF]
Gene, 1985 The chromosomal translocation associated with many tumors of immunoglobulin-producing cells frequently results in the joining of the immunoglobulin heavy-chain locus and the c-myc oncogene. This translocation of c-myc has profound structural and functional consequences for the oncogene, including loss of the 5' end of the gene and transcriptional ...
Dunnick, Wesley A. +4 more
openaire +3 more sources
Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells. [PDF]
PLoS ONE, 2008 Embryonic stem (ES) cell pluripotency is regulated in part by transcription factor (TF) pathways that maintain self-renewal and inhibit differentiation. Stat3 and c-Myc TFs are essential for maintaining mouse ES cell self-renewal.
Benjamin L Kidder +2 more
doaj +1 more source
Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis [PDF]
, 2004 Background Tumour regression observed in many conditional mouse models following oncogene inactivation provides the impetus to develop, and a platform to preclinically evaluate, novel therapeutics to inactivate specific oncogenes.
Abouna, Sylvie +11 more
core +1 more source
Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation
Cell Communication and Signaling, 2019 Background While regulated WNT activity is required for normal development and stem cell maintenance, mutations that lead to constitutive activation of the WNT pathway cause cellular transformation and drive colorectal cancer.
Yi-Heng Hao +9 more
doaj +1 more source
Physiological roles of the oncoprotein c-Myc in mouse mammary gland development [PDF]
, 2009 c-Myc, a transcription factor that affects a large number of target genes, is one of the most frequently deregulated oncoproteins in human cancer. The wide-ranging biological functions of c-Myc include regulation of the cell cycle, differentiation ...
Stölzle, Tina
core +1 more source