Results 41 to 50 of about 333,256 (300)
MYC in elongation and repression [PDF]
Nature Reviews Cancer, 2018 Transcription elongation supported by the super elongation complex, and H3K9 methylation and gene repression by G9a mediate the oncogenic function of Myc.
openaire +3 more sources
Genome Recognition by MYC [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 MYC dimerizes with MAX to bind DNA, with a preference for the E-box consensus CACGTG and several variant motifs. In cells, MYC binds DNA preferentially within transcriptionally active promoter regions. Although several thousand promoters are bound under physiological (low MYC) conditions, these represent only a fraction of all accessible, active ...
A. Sabo, B. Amati
openaire +2 more sources
Germinal Centre B Cell Functions and Lymphomagenesis: Circuits Involving MYC and MicroRNAs
Cells, 2019 Background: The transcription factor MYC regulates several biological cellular processes, and its target gene network comprises approximately 15% of all human genes, including microRNAs (miRNAs), that also contribute to MYC regulatory activity.
Marcela Cristina Robaina +2 more
doaj +1 more source
, 2007 The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive.
Salvatore Oliviero +7 more
core +1 more source
Open Life Sciences, 2017 Diverse physiological pathways have been shown to regulate longevity, stress resistance, fecundity and feeding rates, and metabolism in Drosophila. Here we tesed physiological traits in flies with Rheb and Myc- Rheb overexpressed in gut progenitor cells,
Strilbytska Olha M. +5 more
doaj +1 more source
Cytoplasmic MYC is an anti-necroptotic protein
Molecular & Cellular Oncology, 2020 Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a ...
Eun-Woo Lee +2 more
doaj +1 more source
Transcription factor competition regulates lysosomal biogenesis and autophagy
Molecular & Cellular Oncology, 2020 “In the field of observation, chance favours only the prepared mind” (Louis Pasteur). This motto seems to have guided our unexpected results published recently in Nature Communications, where we describe an epigenetic rheostat that regulates expression ...
Alessandra d'Azzo, Ida Annunziata
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Prevalence and Prognostic Impact of MYC, BCL2, and BCL6 Rearrangements in Large B Cell Lymphoma Patients: A Multicenter Historical Cohort Study from Iran [PDF]
Middle East Journal of CancerBackground: Diffuse large B cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin's lymphoma, characterized by remarkable molecular heterogeneity.
Fatemeh Radmanesh +4 more
doaj +1 more source
eLife, 2020 The numerous neurons and glia that form the brain originate from tightly controlled growth and division of neural stem cells, regulated systemically by important known stem cell-extrinsic signals.
Tamsin J Samuels +3 more
doaj +1 more source