Results 11 to 20 of about 294,417 (155)
Cancer Research, 2011 Abstract Aggressive primary tumors express transcriptional signatures that correlate with their metastatic propensity. A number of these signatures have been deployed in the clinic as risk stratification tools. However, the molecular basis of these clinically useful prognostic signatures has remained a largely unresolved area of ...
Anita, Wolfer, Sridhar, Ramaswamy
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Biology Open, 2021 Human induced pluripotent stem cells (iPSCs) are important source for regenerative medicine. However, the links between pluripotency and oncogenic transformation raise safety issues.
Minglin Ou +11 more
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Cancer Cell, 2008 In this issue of Cancer Cell, Murphy et al. describe a mouse model designed to examine the biological effects of different levels of deregulated c-myc expression. They provide evidence that distinct threshold levels of Myc are required for increased proliferation and for apoptosis in different tissues.
Freie, Brian W., Eisenman, Robert N.
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TP53 loss initiates chromosomal instability in fallopian tube epithelial cells
Disease Models & Mechanisms, 2021 High-grade serous ovarian cancer (HGSOC) originates in the fallopian tube epithelium and is characterized by ubiquitous TP53 mutation and extensive chromosomal instability (CIN).
Daniel Bronder +16 more
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Cold Spring Harbor Perspectives in Medicine, 2014 The MYC oncoprotein is an essential transcription factor that regulates the expression of many genes involved in cell growth, proliferation, and metabolic pathways. Thus, it is important to keep MYC activity in check in normal cells in order to avoid unwanted oncogenic changes.
Amy S, Farrell, Rosalie C, Sears
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Oncogenic MYC amplifies mitotic perturbations [PDF]
Open Biology, 2019 The oncogenic transcription factor MYC modulates vast arrays of genes, thereby influencing numerous biological pathways including biogenesis, metabolism, proliferation, apoptosis and pluripotency.
Samantha Littler +5 more
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Drug therapy for double-hit lymphoma
Drugs in Context, 2019 Double-hit lymphoma (DHL) is a rare type of aggressive B-cell lymphoma defined as a high-grade B-cell lymphoma (HGBCL) with the presence of MYC, BCL2 and/or BCL6 rearrangements.
Vania Phuoc +2 more
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OncoImmunology, 2020 The main mechanism of action of RRx-001, a pharmaceutically unprecedented sui generis Phase 3 small molecule that is derived from the aerospace industry, is clarified.
Bryan Oronsky +5 more
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Myc-Nick: The Force Behind c-Myc [PDF]
Science Signaling, 2010 A cytoplasmic form of c-Myc promotes microtubule stability and cell differentiation.
Kambiz, Mousavi, Vittorio, Sartorelli
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Nature Communications, 2018 Metabolic rewiring of cancer cells can be driven by both extrinsic and intrinsic factors. Here the authors show that microenvironmental factors induce metabolic rewiring of B-cell lymphoma through activation of STAT3 and NF-ΚB resulting in upregulation ...
Maren Feist +18 more
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