Results 11 to 20 of about 333,256 (300)
Restaurant wastewater treatment with a two-chamber septic tank and a sequencing batch reactor [PDF]
E3S Web of Conferences, 2021 Restaurant wastewater in Indonesia comprises a variety of organic components that are difficult to degrade, such as COD, BOD, TSS, and oils and fats. Although grease traps are usually used to collect restaurant wastewater, the effluent still exceeds the ...
Hendrasarie Novirina +2 more
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Biology Open, 2021 Human induced pluripotent stem cells (iPSCs) are important source for regenerative medicine. However, the links between pluripotency and oncogenic transformation raise safety issues.
Minglin Ou +11 more
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TP53 loss initiates chromosomal instability in fallopian tube epithelial cells
Disease Models & Mechanisms, 2021 High-grade serous ovarian cancer (HGSOC) originates in the fallopian tube epithelium and is characterized by ubiquitous TP53 mutation and extensive chromosomal instability (CIN).
Daniel Bronder +16 more
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Cancer Cell, 2008 In this issue of Cancer Cell, Murphy et al. describe a mouse model designed to examine the biological effects of different levels of deregulated c-myc expression. They provide evidence that distinct threshold levels of Myc are required for increased proliferation and for apoptosis in different tissues.
Freie, Brian W., Eisenman, Robert N.
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The Molecular ‘Myc-anisms’ behind Myc-Driven Tumorigenesis and the Relevant Myc-Directed Therapeutics [PDF]
International Journal of Molecular Sciences, 2020 MYC, a well-studied proto-oncogene that is overexpressed in >20% of tumors across all cancers, is classically known as “undruggable” due to its crucial roles in cell processes and its lack of a drug binding pocket. Four decades of research and creativity led to the discovery of a myriad of indirect (and now some direct!) therapeutic strategies ...
Jessica McAnulty, Analisa DiFeo
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Oncogenic MYC amplifies mitotic perturbations [PDF]
Open Biology, 2019 The oncogenic transcription factor MYC modulates vast arrays of genes, thereby influencing numerous biological pathways including biogenesis, metabolism, proliferation, apoptosis and pluripotency.
Samantha Littler +5 more
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Cancer Research, 2011 Abstract Aggressive primary tumors express transcriptional signatures that correlate with their metastatic propensity. A number of these signatures have been deployed in the clinic as risk stratification tools. However, the molecular basis of these clinically useful prognostic signatures has remained a largely unresolved area of ...
Anita, Wolfer, Sridhar, Ramaswamy
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Myc-Nick: The Force Behind c-Myc [PDF]
Science Signaling, 2010 A cytoplasmic form of c-Myc promotes microtubule stability and cell differentiation.
Kambiz, Mousavi, Vittorio, Sartorelli
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Drug therapy for double-hit lymphoma
Drugs in Context, 2019 Double-hit lymphoma (DHL) is a rare type of aggressive B-cell lymphoma defined as a high-grade B-cell lymphoma (HGBCL) with the presence of MYC, BCL2 and/or BCL6 rearrangements.
Vania Phuoc +2 more
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