The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain. [PDF]
PLoS ONE, 2014 BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ∼40% of diffuse large B-cell lymphoma.
Sian E Evans +7 more
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BCL6 inhibition: a promising approach to prevent germinal center-driven allo-immune responses [PDF]
Frontiers in ImmunologyAfter solid organ transplantation, antibody-mediated rejection (AMR) is the most important cause of late allograft loss. Central in this process are donor-specific antibodies (DSAs) targeting mismatched Human Leukocyte Antigens (HLA) on recipient ...
Rens Kraaijeveld +4 more
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Role of c-MYC, BCL2, and BCL6 Expression in Pathogenesis of Diffuse Large B-Cell Lymphoma
Клиническая онкогематология, 2014 According to modern concepts based on results of examination of the gene expression profile, there are several subtypes of diffuse large B cell lymphoma (DLBCL): germinal center B cell-like (GCB) and activated B cell-like (ABC) lymphomas.
A. E. Misyurina +4 more
doaj +3 more sources
Vitamin D receptor expression in germinal centre type diffuse large B-cell lymphoma cells is associated with vitamin D insensitivity [PDF]
Endocrine OncologyObjective: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of non-Hodgkin lymphomas (NHLs) often sub-classified into major germinal centre (GC) and activated B-cell (ABC) cell-of-origin types.
Elizabeth J Soilleux +8 more
doaj +2 more sources
Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation [PDF]
Cell Reports, 2019 Summary: B cell lymphoma-6 (BCL6) is highly expressed in germinal center B cells, but how its expression is maintained is still not completely clear. Aryl hydrocarbon receptor interacting protein (AIP) is a co-chaperone of heat shock protein 90. Deletion
Dijue Sun +15 more
doaj +6 more sources
Bcl6 promotes follicular helper T‐cell differentiation and PD‐1 expression in a Blimp1‐independent manner in mice [PDF]
European Journal of Immunology, 2017 The transcription factors Bcl6 and Blimp1 have opposing roles in the development of the follicular helper T (TFH) cells: Bcl6 promotes and Blimp1 inhibits TFH-cell differentiation.
Markus M Xie +2 more
exaly +3 more sources
Protein and Cell, 2016 The BCL6 (B-Cell Lymphoma 6) gene is a proto-oncogene that is often expressed in diffuse large B-cell lymphomas (DLBCLs). BCL6 loss of function can kill DLBCL cells, demonstrating that BCL6 is necessary for the survival of DLBCL cells and could be a ...
Hongwei Liang, Huilai Zhang, Lanfang Li
exaly +3 more sources
Loss of Bcl6 promotes antitumor immunity by activating glycolysis to rescue CD8 T-cell function [PDF]
Life Science AllianceBCL6 limits CD8 T-cell responses to tumors by inhibiting Glut3 expression. Conditional deletion of Bcl6 in activated CD8 T cells or pharmacological inhibition of BCL6 in mice represses tumor growth.
Fangkun Luan +8 more
doaj +2 more sources
Pharmaceutical inhibition of BCL6 ameliorates resistance to imatinib in chronic myeloid leukemia [PDF]
HeliyonThe tyrosine kinase inhibitors (TKIs) have improved overall survival of CML (chronic myeloid leukemia) patients and allow them to experience normal life expectancy. However, relapse and drug resistance remain the main challenges in the clinical treatment
Yingying Xiao +3 more
doaj +2 more sources
Hypoxic stress caused apoptosis of MDBK cells by p53/BCL6-mitochondrial apoptosis pathway [PDF]
Animal BiotechnologyHypoxia is an important characteristic of Tibetan plateau environment. It can lead to apoptosis, but the mechanism of apoptosis caused by hypoxic stress needs further clarification. Here, cattle kidney cell MDBK were used as cell model.
Bin Li +6 more
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