Results 1 to 10 of about 22,830 (227)

Double-hit primary high-grade gastric B-cell lymphoma presenting with pancytopaenia and atraumatic back pain: A case report. [PDF]

World J Gastrointest Pharmacol Ther
Fu MY, Jia K, Lee C, O'Neill RS, Thilakanathan C, Turner I.   +5 more
europepmc   +1 more source

Beyond the Nodes: Atypical Presentations of Non-Hodgkin's Lymphoma Across Organs. [PDF]

Cureus
A S, D'Cruze L, Archana B, Sundaram S, Priyathersini N.   +4 more
europepmc   +1 more source

Occult primary prostate lymphoma in a young male: A case report. [PDF]

Urol Case Rep
Jacinto RM, Cobangbang M, Geron MAV.
europepmc   +1 more source

Diffuse Large B-Cell Lymphoma of the Ethmoid Sinus With Orbital Invasion: A Case Report. [PDF]

Cureus
Boualam Y, Sbai A, Benfadil D, Lachkar A.   +3 more
europepmc   +1 more source

High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma [PDF]

Blood, 2006
AbstractTo investigate the role of BCL6 in the pathogenesis of gastric lymphoma, we analyzed the BCL6 promoter region for BCL6 translocations, somatic hypermutations, and deregulating mutations in 43 gastric lymphomas, including 4 extranodal marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissues (MALT lymphomas), 33 diffuse large B-cell ...
Liang, AC, Chen, YW, Hu, XT, Au, WY, Wong, ML, Shen, L, Tao, Q, So, CC, Srivastava, G, Liang, RH, Kwong, YL, Chu, KM   +11 more
openaire   +5 more sources

BCL6 as a therapeutic target for lymphoma

Expert Opinion on Therapeutic Targets, 2018
B cell lymphoma 6 (BCL6) is a transcriptional repressor critical for the development and maintenance of germinal centers (GCs), which are required for generation of an effective humoral immune response. Genomic aberrations of BCL6, including mutations and translocations that occur during the GC reaction, as well as alterations of genes that regulate ...
Rebecca J, Leeman-Neill, Govind, Bhagat
openaire   +2 more sources

A-Miz-ing BCL6

Nature Immunology, 2005
Germinal center formation requires BCL6 to silence specific genes in B cells. New data now show that the repertoire of genes repressed by BCL6 is larger than previously thought, because of its interaction with the DNA-binding protein Miz-1.
Xiaosheng Wu, Diane F Jelinek
openaire   +1 more source

Discovery of Potent and Selective BCL6 Ligand-Directed Degrader (LDD), BCL6-760

Journal of Medicinal Chemistry
The discovery of a potent and selective BCL6 ligand-directed degrader (LDD), BCL6-760 (45) is described. Through structure-activity relationships, the most potent heterobifunctional degraders of BCL6 were found to be those containing short aminopiperidine linkers in combination with an indazole-based cereblon (CRBN)-binding moiety (CBM).
Hunter P. Shunatona, Natalie Holmberg Douglas, Jayce Rhodes, William Thomas, Diogo Da Silva, Jim Gamez, Matt Groza, Andy Christoforou, Jinyi Zhu, Scott Johnson, Dharmpal Dodd, Dehua Huang, Jennifer Griffin, Giulianna Miseo, Brandon Whitefield, Dahlia Weiss, James Rader, Elif Kuzu, Jim Leisten, Joselyn Del Rosario, Lihong Shi, Mary Matyskiela, Philip P. Chamberlain, Peter Belmont, Matt Alexander, Christoph W. Zapf, Lynda Groocock, Deborah S. Mortensen   +27 more
openaire   +2 more sources

Bcl6-dependent transcriptional repression by BAZF

Biochemical and Biophysical Research Communications, 2003
BAZF, a member of Bcl6 gene family, acts as a sequence-specific transcriptional repressor in various cells including NIH3T3 cells. The DNA-binding sequence for BAZF is the same as that for Bcl6 and the repressor activity of BAZF was also inhibited by Tricostatin A, an inhibitor of histone deacetylase, suggesting the functional homology between them ...
Masanori, Takenaga, Masahiko, Hatano, Mikio, Takamori, Yoshihiro, Yamashita, Seiji, Okada, Yoshikazu, Kuroda, Takeshi, Tokuhisa   +6 more
openaire   +2 more sources

Acetylation inactivates the transcriptional repressor BCL6

Nature Genetics, 2002
The proto-oncogene BCL6 encodes a BTB/POZ-zinc finger transcriptional repressor that is necessary for germinal-center formation and has been implicated in the pathogenesis of B-cell lymphomas. Here we show that the co-activator p300 binds and acetylates BCL6 in vivo and inhibits its function.
Oksana R, Bereshchenko, Wei, Gu, Riccardo, Dalla-Favera   +2 more
openaire   +2 more sources