The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain. [PDF]
PLoS ONE, 2014 BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ∼40% of diffuse large B-cell lymphoma.
Sian E Evans +7 more
doaj +9 more sources
High-Grade B-Cell Lymphoma (HGBL) with MYC and BCL2 and/or BCL6 Rearrangements Is Predominantly BCL6-Rearranged and BCL6-Expressing in Taiwan [PDF]
Cancers, 2021 This study investigated the epidemiological and clinical peculiarities of BCL2 and BCL6 rearrangement in patients with high grade B-cell lymphoma (HGBL) from Taiwan, compared with data from Western countries. Two hundred and eighty-two DLBCL cases from Taipei Medical University-affiliated hospitals (n = 179) and Tri-Service General Hospital (n = 103 ...
Cheng-Chih Tsai +23 more
openaire +4 more sources
FTO-mediated m6A demethylation of BCL6 promotes gastric cancer progression by suppressing ferroptosis [PDF]
RNA BiologyB-cell lymphoma 6 (BCL6) functions in various cancers, but its role and regulation in gastric cancer (GC) remain unclear. N6-methyladenosine (m6A) modification is critical for tumorigenesis, and the demethylase FTO (highly expressed in GC) may regulate ...
Yan Wang +4 more
doaj +2 more sources
BCL6 regulates skeletal muscle mass and mitochondrial bioenergetics [PDF]
Molecular MetabolismThe transcriptional repressor B cell lymphoma 6 (BCL6) is highly expressed in skeletal muscle. Although transcriptome-wide studies have shown BCL6 dysregulation in muscular dystrophies, investigations into its endogenous roles in muscle biology remain ...
Shirine E. Usmani +23 more
doaj +2 more sources
Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation [PDF]
Cell Reports, 2019 Summary: B cell lymphoma-6 (BCL6) is highly expressed in germinal center B cells, but how its expression is maintained is still not completely clear. Aryl hydrocarbon receptor interacting protein (AIP) is a co-chaperone of heat shock protein 90. Deletion
Dijue Sun +15 more
doaj +3 more sources
A lipid nanoparticle-based peptide-proteolysis-targeting chimera degrades BCL6 for diffuse large B-cell lymphoma treatment [PDF]
Discover OncologyB-cell lymphoma 6 (BCL6) is an attractive drug target for diffuse large B-cell lymphoma (DLBCL). This study aimed to create a lipid nanoparticle (LNP)-based peptide-proteolysis-targeting chimera (PROTAC), specifically BCL6-PROTAC, to develop effective ...
Shiwei Liu +11 more
doaj +2 more sources
Protein and Cell, 2016 The BCL6 (B-Cell Lymphoma 6) gene is a proto-oncogene that is often expressed in diffuse large B-cell lymphomas (DLBCLs). BCL6 loss of function can kill DLBCL cells, demonstrating that BCL6 is necessary for the survival of DLBCL cells and could be a ...
Hongwei Liang +2 more
exaly +3 more sources
Cell Reports, 2020 Summary: It is unknown whether the incremental increases in BCL6 amounts in antigen-activated B cells influence the unfolding differentiation before germinal center (GC) formation.
Marcus J Robinson +2 more
exaly +3 more sources
Endometrial BCL6 Expression and Reproductive Outcomes in Infertile Women: A Systematic Review [PDF]
DiagnosticsBackground/Objectives: Endometrial B-cell lymphoma 6 (BCL6) overexpression has been proposed as a marker of progesterone resistance, occult endometriosis, and endometrial dysfunction in infertile women. Its possible association with reproductive outcomes
Ana Maria Mihoci +8 more
doaj +2 more sources
Vitamin D receptor expression in germinal centre type diffuse large B-cell lymphoma cells is associated with vitamin D insensitivity [PDF]
Endocrine OncologyObjective: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of non-Hodgkin lymphomas (NHLs) often sub-classified into major germinal centre (GC) and activated B-cell (ABC) cell-of-origin types.
Elizabeth J Soilleux +8 more
doaj +2 more sources