JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms. [PDF]
, 2016 JMJD3 (Jumonji domain containing-3), a histone H3 Lys27 (H3K27) demethylase, has been reported to be involved in the antigen-driven differentiation of germinal center B-cells.
Bai, Nan +10 more
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A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era. Selecting cases, matching clinical benefit. A position paper from the Italian Group of Haematopathology (G.I.E.) [PDF]
, 2019 An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical ...
Agostinelli, C. +17 more
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The Role of BCL6 in Glioblastoma [PDF]
, 2021 <p>Glioblastoma (GBM) is the most common and most deadly brain tumour to occur in adults. Initially patients respond to radiation and chemotherapy, which primarily work by causing large amounts of DNA damage, leading to cell death. However, this process does not happen effectively in GBM and understanding how these cells resist cell death in ...
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PLoS ONE, 2014 The transcriptional repressor BCL6 plays an essential role in the development of germinal center B cells and follicular helper T cells. However, much less is known about the expression and function of BCL6 in other cell types.
Ting-ting Zhang +5 more
doaj +1 more source
A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation [PDF]
, 2014 Induction of Bcl6 (B cell lymphoma 6) is essential for T follicular helper (Tfh) cell differentiation of antigen-stimulated CD4(+) T cells. Intriguingly, we found that Bcl6 was also highly and transiently expressed during the CD4(+)CD8(+) (double ...
Bendelac, Albert +12 more
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The chronic myeloid leukemia stem cell: stemming the tide of persistence [PDF]
, 2017 Chronic myeloid leukaemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a haemopoietic stem cell (HSC), transforming it into a leukaemic stem cell (LSC) that self-renews, proliferates and differentiates to give rise to a ...
Holyoake, Tessa L., Vetrie, David
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Mixed Signals: T Cells as Architects of IgE Immunity. [PDF]
Immunol RevABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Tierney AL +3 more
europepmc +2 more sources
BCL6 inhibition: a chronic GVHD twofer [PDF]
Blood, 2019 In this issue of Blood, Paz and colleagues demonstrate that the small molecule 79-6 is able to treat and even reverse lung injury attributable to experimental chronic graft-versus-host disease (cGVHD) by targeting B-cell lymphoma 6 (BCL6), a transcriptional regulator of T follicular helper (Tfh) cells and germinal center B cells.
Paola Vinci, Alan M. Hanash
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IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection [PDF]
, 2016 Funding: This work was funded by a Career Development Fellowship (1028634) and a project grant (GRNT1028641) awarded to AHa by the Australian National Health & Medical Research Council (NHMRC).
A Haque +89 more
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The roles of resident, central and effector memory CD4 T cells in protective immunity following infection or vaccination [PDF]
, 2018 Immunological memory provides rapid protection to pathogens previously encountered through infection or vaccination. CD4 T cells play a central role in all adaptive immune responses.
Gray, Joshua I. +2 more
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