Results 41 to 50 of about 22,830 (227)
Diffuse large B-cell lymphoma with concomitant c-MYC and BCL6 gene rearrangements with primary skin involvement: A case report and a review of literature [PDF]
Терапевтический архив, 2017 Double-hit lymphoma (DHL) is a rare aggressive B-cell lymphoma with concomitant c-MYC, BCL2 or BCL6 gene rearrangements, which is characterized by the high frequency of extranodal lesions and by resistance to chemotherapy.
N G Gabeeva +9 more
doaj +1 more source
BCL6 is elevated in steady-state cDCs. [PDF]
, 2014 (A) Splenocytes from naïve C57BL/6 mice were stained for cDCs subsets or pDCs, and for intracellular BCL6 protein expression. Representative FACS plots were shown (n = 8): Isotype controls (solid grey), BCL6 expression of GC B cells gated as described in
Giorgio Cattoretti (568042) +5 more
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BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer
The Journal of Clinical Investigation, 2022 Mutational activation of KRAS is a common oncogenic event in lung cancer, yet effective therapies are still lacking. Here, we identify B cell lymphoma 6 (BCL6) as a lynchpin in KRAS-driven lung cancer.
Kun Li +13 more
doaj +1 more source
The Role of BCL6 in Glioblastoma [PDF]
, 2018 Glioblastoma (GBM) is the most common and most deadly brain tumour to occur in adults. Initially patients respond to radiation and chemotherapy, which primarily work by causing large amounts of DNA damage, leading to cell death.
Jones, Nicole, Jones, Nicole (11748365)
core +1 more source
Frontiers in Immunology, 2018 Transcriptional repressor B-cell lymphoma 6 (Bcl6) appears to regulate TH2 immune responses in allergies, but its precise role is unclear. We previously reported that Bcl6 suppressed IL-4 production in naïve CD4+ T cell-derived memory TH2 cells.
Takashi Ogasawara +16 more
doaj +1 more source
Cell & Bioscience, 2023 Background B-cell lymphoma 6 (BCL6) is a transcription repressor that plays a tumor suppressor or promoting role in various tumors. However, its function and molecular mechanism in gastric cancer (GC) remain unclear.
Shiwei Guo +8 more
doaj +1 more source
The Role of BCL6 in Glioblastoma [PDF]
, 2021 <p>Glioblastoma (GBM) is the most common and most deadly brain tumour to occur in adults. Initially patients respond to radiation and chemotherapy, which primarily work by causing large amounts of DNA damage, leading to cell death. However, this process does not happen effectively in GBM and understanding how these cells resist cell death in ...
openaire +1 more source
Hit-and-run lymphomagenesis by theBcl6oncogene [PDF]
Cell Cycle, 2014 Editorials: Cell Cycle ...
Green, Michael R. +3 more
openaire +3 more sources
Development of a Novel B‑Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6 [PDF]
, 2018 B-cell lymphoma 6 (BCL6) inhibition is a promising mechanism for treating hematological cancers but high quality chemical probes are necessary to evaluate its therapeutic potential.
Michael Zinda (2238178) +36 more
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BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma [PDF]
, 2009 The BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center (GC) formation and whose deregulation by genomic lesions is implicated in the pathogenesis of GC-derived diffuse large B cell lymphoma (DLBCL) and, less ...
Chadburn, Amy +24 more
core +1 more source