Results 51 to 60 of about 22,830 (227)
BCL6 attenuates renal inflammation via negative regulation of NLRP3 transcription [PDF]
, 2017 Renal inflammation contributes to the pathogeneses of hypertension. This study was designed to determine whether B-cell lymphoma 6 (BCL6) attenuates renal NLRP3 inflammasome activation and inflammation and its underlying mechanism.
Yu-Ming Kang +9 more
core +1 more source
PLoS ONE, 2014 The transcriptional repressor BCL6 plays an essential role in the development of germinal center B cells and follicular helper T cells. However, much less is known about the expression and function of BCL6 in other cell types.
Ting-ting Zhang +5 more
doaj +1 more source
BCL6 controls Th9 cell development by repressing Il9 transcription [PDF]
, 2014 The transcriptional repressor B cell lymphoma 6 (BCL6) is required for the development of Th follicular cells, and it has been shown to suppress Th2 cell differentiation. We demonstrate that BCL6 is a key regulator of Th9 cell development.
Frangieh, Michael +7 more
core +1 more source
BCL6 inhibition: a chronic GVHD twofer [PDF]
Blood, 2019 In this issue of Blood, Paz and colleagues demonstrate that the small molecule 79-6 is able to treat and even reverse lung injury attributable to experimental chronic graft-versus-host disease (cGVHD) by targeting B-cell lymphoma 6 (BCL6), a transcriptional regulator of T follicular helper (Tfh) cells and germinal center B cells.
Paola Vinci, Alan M. Hanash
openaire +2 more sources
Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia [PDF]
, 2019 Chromosomal rearrangements of the mixed lineage leukemia (MLL) gene occur in ∼10% of B-cell acute lymphoblastic leukemia (B-ALL) and define a group of patients with dismal outcomes.
Ernst, Patricia +13 more
core +1 more source
BCL6 plays a role in regulating IFNβ activity. [PDF]
, 2022 A) Bcl6 was silenced in B6.C3-Bbaa1 BMDMs by transfection of Bcl6 siRNA. Transfected cells were allowed to rest for 48 h and were then incubated with sonicated B. burgdorferi for 6 h prior to collection for RNA isolation. Transfected cells were incubated
Ying Ma (123771) +7 more
core +1 more source
Role of c-MYC, BCL2, and BCL6 Expression in Pathogenesis of Diffuse Large B-Cell Lymphoma
Клиническая онкогематология, 2014 According to modern concepts based on results of examination of the gene expression profile, there are several subtypes of diffuse large B cell lymphoma (DLBCL): germinal center B cell-like (GCB) and activated B cell-like (ABC) lymphomas.
A. E. Misyurina +4 more
doaj +1 more source
CtBP Is an Essential Corepressor for BCL6 Autoregulation [PDF]
Molecular and Cellular Biology, 2008 The transcription repressor BCL6 plays an essential role in the formation and function of germinal centers (GCs). While normal B cells promptly shut off BCL6 when they exit the GC, many GC-derived B-cell lymphomas sustain BCL6 expression through chromosomal translocations and activating mutations.
Lourdes M, Mendez +6 more
openaire +2 more sources
miR-30b-5p inhibits osteoblast differentiation through targeting BCL6 [PDF]
, 2022 Human bone marrow mesenchymal stem cells (hBMSCs) are attractive candidates for new therapies to improve bone regeneration and repair. This study was to identify the function of the miR-30b-5p/BCL6 axis in osteogenic differentiation of hBMSCs.
Bin Ye (686390) +4 more
core +1 more source
Predicting implantation failure: to BCL6 or not to BCL6 [PDF]
Fertility and Sterility, 2022 Alyssa K. Kosturakis, Ginny L. Ryan
openaire +2 more sources