Results 71 to 80 of about 22,830 (227)

BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells [PDF]

, 2021
B-cell lymphoma 6 (BCL6) is a transcription repressor and proto-oncogene that plays a crucial role in the innate and adaptive immune system and lymphoid neoplasms. However, its role in myeloid malignancies remains unclear.
Wouters, Bas, Roboz, GJ, Melnick, A, Goswami, S, Chen, Zhigang, Wyman, S, Guzman, ML, Carroll, M, Kawabata, KC, Meydan, C, Mason, CE, Delwel, Ruud, Yip, W, Zong, H, Albert, M, Sugita, M   +15 more
core   +1 more source

The organization of the BCL6 gene.

Leukemia, 1994
The chromosomal translocation involving 3q27 has been recently described in B-cell malignancies, especially in diffuse large cell lymphomas. We have previously cloned the breakpoint cluster region of 3q27 designated as the BCL6 locus, previously known as BCL5, and subsequently cloned the cDNA for the BCL6 (we previously reported it as BCL5) gene ...
N, Kawamata, T, Miki, T, Fukuda, S, Hirosawa, N, Aoki   +4 more
openaire   +3 more sources

Bcl6 Is Required for Somatic Hypermutation and Gene Conversion in Chicken DT40 Cells. [PDF]

PLoS ONE, 2016
The activation induced cytosine deaminase (AID) mediates diversification of B cell immunoglobulin genes by the three distinct yet related processes of somatic hypermutation (SHM), class switch recombination (CSR), and gene conversion (GCV). SHM occurs in
Alan M Williams, Yaakov Maman, Jukka Alinikula, David G Schatz   +3 more
doaj   +1 more source

NAC1 attenuates BCL6 negative autoregulation and functions as a BCL6 coactivator of FOXQ1 transcription in cancer cells

Aging, 2020
Nucleus accumbens-associated protein 1 (NAC1) has multifaceted roles in cancer pathogenesis and progression, including the development of drug resistance, promotion of cytokinesis, and maintenance of "stem cell-like" phenotypes. NAC1 is a transcriptional co-regulator belonging to the bric-a-brac tramtrack broad (BTB) family of proteins, although it ...
Gao, Min, Herlinger, Alice Laschuk, Wu, Renchin, Wang, Tian-Li, Shih, Ie-Ming, Kong, Beihua, Rangel, Leticia Batista Azevedo, Yang, Jin-Ming   +7 more
openaire   +2 more sources

Primary Bone Lymphoma and BCL6 [PDF]

American Journal of Clinical Pathology, 2009
We read with great interest the article by Lima et al.1 In this article, the incidence rates of BCL2 and c- MYC among primary bone lymphomas were 28% (9/32) and 9% (3/32), respectively, with negative results for BCL6, PAX5, ALK, and BCL1 rearrangements Table 1 . Owing to the absence of a BCL6 gene rearrangement and a higher incidence of BCL2 and c- MYC
Sharathkumar Bhagavathi, Kai Fu
openaire   +1 more source

DNA (cytosine‐5)‐methyltransferase 3A (Dnmt3a) mutations limit normal and autoreactive CD4+ T follicular helper responses and attenuate T cell‐driven joint inflammation

Arthritis &Rheumatology, Accepted Article.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased inflammatory markers. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per‐Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling   +10 more
wiley   +1 more source

BCL6 is potentially involved in miR-127-mediated cellular senescence. [PDF]

, 2013
(A–B) Growth curves of WI-38 and IMR-90 cells transiently transfected with 50 nM BCL6 siRNA or negative control. Growth curves were generated by cell number at indicated times. Data are presented as the mean ± SD from three-independent experiments.
Yuntao Xie (489530), Mingzhou Guo (132201), Jingwen Chen (489529), Yu-Sheng Cong (411883), Miao Wang (248377)   +4 more
core   +1 more source

Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity

Cell Reports, 2018
Summary: Accumulation of visceral adiposity is directly linked to the morbidity of obesity, while subcutaneous body fat is considered more benign. We have identified an unexpected role for B cell lymphoma 6 (BCL6), a critical regulator of immunity, in ...
Madhavi D. Senagolage, Meredith A. Sommars, Krithika Ramachandran, Christopher R. Futtner, Yasuhiro Omura, Amanda L. Allred, Jianing Wang, Cynthia Yang, Daniele Procissi, Ronald M. Evans, Xianlin Han, Ilya R. Bederman, Grant D. Barish   +12 more
doaj   +1 more source

The Growth Supporting Role of ZDHHC11 Is Linked to the MEF2B–BCL6 Regulatory Circuit in Burkitt Lymphoma

International Journal of Cancer, EarlyView.
MEF2B and BCL6 have established functions in germinal center B‐cell biology and lymphomagenesis. The mechanism of MEF2B deregulation and its significance for cell survival in Burkitt lymphoma however remain unclear. This study highlights MEF2B as a crucial transcription factor in Burkitt lymphoma and suggests ZDHHC11 as an upstream regulator of MEF2B ...
Lotteke J. Y. M. Ziel‐Swier, Karolina Rassek, Yichen Liu, Annika Seitz, Jasper Koerts, Debora de Jong, Bea Rutgers, Anastasiia Kompaniiets, Julia Przybył, Martine E. D. Chamuleau, Anke van den Berg, Agnieszka Dzikiewicz‐Krawczyk, Joost Kluiver   +12 more
wiley   +1 more source

Structure of the wild-type human BCL6 POZ domain. [PDF]

, 2008
BCL6 is a transcriptional repressor that is overexpressed in diffuse large B-cell lymphoma and follicular lymphoma. The N-terminal POZ domain of BCL6 interacts with transcriptional corepressors and targeting these associations is a promising therapeutic ...
Wright, SC, Trinh, CH, Stead, MA, Rosbrook, GO, Hadden, JM, Carr, SB   +5 more
core   +1 more source