Results 71 to 80 of about 35,489 (280)

Hypothalamic BCL6 signaling modulates energy homeostasis and metabolism by inhibiting STAT3 transcription

Journal of Advanced Research
Introduction: B-cell leukemia/lymphoma 6 (BCL6) has been implicated in regulating energy metabolism in peripheral tissues; however, its role in the hypothalamic regulation of energy homeostasis remains poorly defined.
Hongdong Han, Qinge Li, Cong Wang, Zerong Liang, Lianying Zhang, Siliang Zhang, Mingyuan Tian, Shengbing Li, Dongfang Liu, Gangyi Yang, Mengliu Yang, Ling Li   +11 more
doaj   +1 more source

High expressions of BCL6 and Lewis y antigen are correlated with high tumor burden and poor prognosis in epithelial ovarian cancer

Tumor Biology, 2017
Aberrant regulation of BCL6 plays crucial oncogenic roles in various malignant tumors; howbeit, the function of BCL6 in tumorigenesis of ovarian cancer remains unclear. The aim of this study is to investigate the role of BCL6 in ovarian cancer.
Liancheng Zhu, Huilin Feng, Shan Jin, Mingzi Tan, Song Gao, Huiyu Zhuang, Zhenhua Hu, Huimin Wang, Zuofei Song, Bei Lin   +9 more
doaj   +1 more source

Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation

Frontiers in Cell and Developmental Biology, 2019
B cell lymphoma is a clinically heterogeneous and pathologically diverse group of diseases with a strong epigenetic component. The B cell lymphoma 6 (BCL6) gene encodes a transcription factor that is critical for normal germinal center reaction B cell ...
Haopeng Yang, Michael R. Green, Michael R. Green   +2 more
doaj   +1 more source

Inhibition of doxorubicin-induced senescence by PPARδ activation agonists in cardiac muscle cells: cooperation between PPARδ and Bcl6. [PDF]

PLoS ONE, 2012
Senescence and apoptosis are two distinct cellular programs that are activated in response to a variety of stresses. Low or high doses of the same stressor, i.e., the anticancer drug doxorubicin, may either induce apoptosis or senescence, respectively ...
Paola Altieri, Paolo Spallarossa, Chiara Barisione, Silvano Garibaldi, Anna Garuti, Patrizia Fabbi, Giorgio Ghigliotti, Claudio Brunelli   +7 more
doaj   +1 more source

Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T‐Cell Enhancement in Immunocompetent HLA‐Transgenic Mice

Allergy, EarlyView.
Upregulated HLA‐B*57:01 expression in Tg/KO mice amplifies abacavir‐specific CD8+ T‐cell activation, driven by enhanced antigen presentation. Abacavir treatment induces robust pDC expansion and IFN‐α production, which selectively suppresses memory Treg populations.
SuJin Hwang, Telly Sepahpour, Stephanie Kortchak, Kirthiram Krishnaveni Sivakumar, Spyros Karaiskos, Ngoc Pham, Yura Jang, Montserrat Puig, Michael Norcross   +8 more
wiley   +1 more source

Chromosomal translocations involving BCL6 in MALT lymphoma

Haematologica, 2008
Chromosomal translocations involving BCL6 were detected in 7 out of 392 cases of MALT lymphoma by interphase fluorescence in situ hybridisation with a BCL6 break-apart probe.
Hongtao Ye, Ellen D. Remstein, Chris M. Bacon, Andrew G. Nicholson, Ahmet Dogan, Ming-Qing Du   +5 more
doaj   +1 more source

Mechanistic Insights Into Recurrent Implantation Failure: The Lactate–H3K18la–SLC7A11 Axis Explored via Endometrial Organoid and Blastoid–Endometrial Cell Implantation Models

Cell Proliferation, EarlyView.
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong, Xiaobin Sun, Shiyu An, Jinfeng Xiang, Lingmin Hu, Dan Yao, Jiaqian Chang, Ruizhe Jia, Yang Yang, Shuxian Wang   +9 more
wiley   +1 more source

The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy.

PLoS ONE, 2020
The prognosis for people with the high-grade brain tumor glioblastoma is very poor, due largely to low cell death in response to genotoxic therapy. The transcription factor BCL6, a protein that normally suppresses the DNA damage response during immune ...
Marie-Sophie Fabre, Nicole M Stanton, Tania L Slatter, Samuel Lee, Dinindu Senanayake, Rosemary M A Gordon, M Leticia Castro, Matthew R Rowe, Ahmad Taha, Janice A Royds, Noelyn Hung, Ari M Melnick, Melanie J McConnell   +12 more
doaj   +1 more source

Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling

Cell Reports, 2020
Summary: The germinal center (GC) reaction is essential for long-lived humoral immunity. However, molecular requirements for the induction of Bcl6, the master regulator for GC B cell differentiation, remain unclear.
Kei Haniuda, Saori Fukao, Daisuke Kitamura   +2 more
doaj   +1 more source

Development and function of protective and pathologic memory CD4 T cells [PDF]

, 2015
Immunological memory is one of the defining features of the adaptive immune system. As key orchestrators and mediators of immunity, CD4 T cells are central to the vast majority of adaptive immune responses.
Jaigirdar, Shafqat Ahrar, Macleod, Megan K.L.   +1 more
core   +3 more sources