Results 81 to 90 of about 22,830 (227)

Correlations between BCL6 rearrangement and outcome in patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP

Haematologica, 2010
Background BCL6 gene rearrangement is the most frequent chromosomal abnormality in diffuse large B-cell lymphoma, a malignancy characterized by genetic heterogeneity and wide variability in clinical outcome.
Jesse Shustik, Guangming Han, Pedro Farinha, Nathalie A. Johnson, Susana Ben Neriah, Joseph M. Connors, Laurie H. Sehn, Douglas E. Horsman, Randy D. Gascoyne, Christian Steidl   +9 more
doaj   +1 more source

Efficacy and Safety Profile of a Rituximab, Methotrexate, and Thiotepa‐Based Regimen in Newly Diagnosed Primary CNS Lymphoma

International Journal of Cancer, EarlyView.
Primary central nervous system diffuse large B‐cell lymphoma (PCNS‐DLBCL) lacks an optimal first‐line induction strategy, particularly for older patients and those ineligible for intensive consolidation. In this retrospective cohort of 36 newly diagnosed patients, the rituximab + methotrexate + thiotepa (RMT) regimen as first‐line induction achieved ...
Haotian Wang, Jia Li, Luming Cao, Ying Zhang, Xin Wan, Xingtong Wang, Yangzhi Zhao, Zhaoxia Li, Chengqian Chen, Yang Song, Ou Bai   +10 more
wiley   +1 more source

BCL6 protein levels correlates with the proliferation marker Ki-67. [PDF]

, 2014
Splenic cDCs were further analyzed for intracellular BCL6 and Ki-67 expression. (A) Co-expression of BCL6 and Ki-67 in splenic total cDCs (right plot). Expression was gated based on staining of mouse IgG1 and Rabbit IgG isotype controls (left plot).
Giorgio Cattoretti (568042), Ting-ting Zhang (421689), Samuele Calabro (590428), Stephanie C. Eisenbarth (260668), Ann M. Haberman (590429), Dong Liu (115204)   +5 more
core   +1 more source

Hypothalamic BCL6 signaling modulates energy homeostasis and metabolism by inhibiting STAT3 transcription

Journal of Advanced Research
Introduction: B-cell leukemia/lymphoma 6 (BCL6) has been implicated in regulating energy metabolism in peripheral tissues; however, its role in the hypothalamic regulation of energy homeostasis remains poorly defined.
Hongdong Han, Qinge Li, Cong Wang, Zerong Liang, Lianying Zhang, Siliang Zhang, Mingyuan Tian, Shengbing Li, Dongfang Liu, Gangyi Yang, Mengliu Yang, Ling Li   +11 more
doaj   +1 more source

High expressions of BCL6 and Lewis y antigen are correlated with high tumor burden and poor prognosis in epithelial ovarian cancer

Tumor Biology, 2017
Aberrant regulation of BCL6 plays crucial oncogenic roles in various malignant tumors; howbeit, the function of BCL6 in tumorigenesis of ovarian cancer remains unclear. The aim of this study is to investigate the role of BCL6 in ovarian cancer.
Liancheng Zhu, Huilin Feng, Shan Jin, Mingzi Tan, Song Gao, Huiyu Zhuang, Zhenhua Hu, Huimin Wang, Zuofei Song, Bei Lin   +9 more
doaj   +1 more source

BCL6 – regulated by AhR/ARNT and wild-type MEF2B – drives expression of germinal center markers MYBL1 and LMO2

Haematologica, 2015
Genetic heterogeneity is widespread in tumors, but poorly documented in cell lines. According to immunoglobulin hypermutation analysis, the diffuse large B-cell lymphoma cell line U-2932 comprises two subpopulations faithfully representing original tumor
Jie Ding, Wilhelm G Dirks, Stefan Ehrentraut, Robert Geffers, Roderick AF MacLeod, Stefan Nagel, Claudia Pommerenke, Julia Romani, Michaela Scherr, Lea AI Vaas, Margarete Zaborski, Hans G Drexler, Hilmar Quentmeier   +12 more
doaj   +1 more source

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

Early Growth Response genes 2 and 3 play a role in chronic inflammation pathology and are essential for the differentiation of T follicular helper cells [PDF]

, 2015
This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University LondonThe Early Growth Response genes 2 and 3 (Egr2/3) are zinc finger transcription factors that play an important role in the immune system.
Ogbe, Ane Theodora
core  

Aberrant expression of CD10 and BCL6 in mantle cell lymphoma [PDF]

, 2017
Aims: Mantle cell lymphoma (MCL) is characterized by distinctive histological and molecular features. Aberrant expression of BCL6 and CD10 has been reported occasionally, but the biological features of such cases are largely unknown.
Matteo Fassan, Mannu, Claudia, Andrea Visentin, Francesco Piazza, Pizzi, Marco, Fassan, Matteo, Semenzato, Gianpietro C, Righi, Simona, Visentin, Andrea, Marco Pizzi, Claudio Agostinelli, Claudia Mannu, Sabattini, Elena, Gianpietro C Semenzato, Massimo Rugge, Simona Righi, Anna Gazzola, Piazza, Francesco, Gazzola, Anna, Galuppini, Francesca, Elena Sabattini, Rugge, Massimo, Francesca Galuppini, Agostinelli, Claudio   +23 more
core   +1 more source

Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation

Frontiers in Cell and Developmental Biology, 2019
B cell lymphoma is a clinically heterogeneous and pathologically diverse group of diseases with a strong epigenetic component. The B cell lymphoma 6 (BCL6) gene encodes a transcription factor that is critical for normal germinal center reaction B cell ...
Haopeng Yang, Michael R. Green, Michael R. Green   +2 more
doaj   +1 more source