Results 91 to 100 of about 35,489 (280)

Impact of SNPs, off-targets, and passive permeability on efficacy of BCL6 degrading drugs assigned by virtual screening and 3D-QSAR approach

Scientific Reports, 2022
B-cell lymphoma 6 (BCL6) regulates various genes and is reported to be overexpressed in lymphomas and other malignancies. Thus, BCL6 inhibition or its tagging for degradation would be an amenable therapeutic approach. A library of 2500 approved drugs was
Solmaz Karimi, Farzaneh Shahabi, Shaden M. H. Mubarak, Hanie Arjmandi, Zahra Sadat Hashemi, Navid Pourzardosht, Alireza Zakeri, Mahdieh Mahboobi, Abolfazl Jahangiri, Mohammad Reza Rahbar, Saeed Khalili   +10 more
doaj   +1 more source

Linking Induction and Transrepression of PPARβ/δ with Cellular Function [PDF]

, 2015
The copyrights of all papers published in this journal are retained by the respective authors as per the 'Creative Commons Attribution License' (http://creativecommons.org/licenses/by/3.0/).Peroxisome proliferator activated receptors (PPARs) are ligand ...
MacKenzie, Louise Susan, Perez Diaz, Noelia   +1 more
core   +3 more sources

Highlights of 2025: advances in germinal centers

Immunology &Cell Biology, EarlyView.
Graphical summary of research advances made in 2025 in germinal center (GC) biology. GCB, germinal center B cells; Tfh, T follicular helper cell; APC, antigen‐presenting cell; FDC, follicular dendritic cell; SHM, somatic hypermutation. Created in BioRender. Webb, L. (2026) https://BioRender.com/bn9jx9v.
Louise MC Webb, Michelle A Linterman
wiley   +1 more source

Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6

Cell Reports, 2017
The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the oncogenic effects of BCL6. We used
Nina Kerres, Steffen Steurer, Stefanie Schlager, Gerd Bader, Helmut Berger, Maureen Caligiuri, Christian Dank, John R. Engen, Peter Ettmayer, Bernhard Fischerauer, Gerlinde Flotzinger, Daniel Gerlach, Thomas Gerstberger, Teresa Gmaschitz, Peter Greb, Bingsong Han, Elizabeth Heyes, Roxana E. Iacob, Dirk Kessler, Heike Kölle, Lyne Lamarre, David R. Lancia, Simon Lucas, Moriz Mayer, Katharina Mayr, Nikolai Mischerikow, Katja Mück, Christoph Peinsipp, Oliver Petermann, Ulrich Reiser, Dorothea Rudolph, Klaus Rumpel, Carina Salomon, Dirk Scharn, Renate Schnitzer, Andreas Schrenk, Norbert Schweifer, Diane Thompson, Elisabeth Traxler, Roland Varecka, Tilman Voss, Alexander Weiss-Puxbaum, Sandra Winkler, Xiaozhang Zheng, Andreas Zoephel, Norbert Kraut, Darryl McConnell, Mark Pearson, Manfred Koegl   +48 more
doaj   +1 more source

BCL6 mRNA Expression Level in Invasive Duct Carcinoma not otherwise Specified [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: B-Cell Lymphoma 6 (BCL6) has an oncogenic role in tumourigenesis of various malignancies. It represses genes involved in terminal differentiation and plays complementary role with Signal Transducer and Activator of Transcription 3 ...
Eman Badr, Eman Masoud, Asmaa Gaber Abdou, Marwa Serag Eldien   +3 more
doaj   +1 more source

Whole Blood Transcriptomic Response to Perioperative Dexamethasone in Total Knee Arthroplasty: A Targeted Panel Analysis

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Changes in the transcriptome of immune cells are predictive of clinical outcomes. These effects may be surgery‐specific and possibly modulated by glucocorticoids. We investigated the immune response and the impact of dexamethasone on the response in patients undergoing total knee arthroplasty (TKA). Methods The transcript levels (n =
Asger Krog Mølgaard, Kasper Smidt Gasbjerg, Lukas Balsevicius, Britt Cappelen, Adile Orhan, Helin Yikilmaz Pardes, Ole Mathiesen, Thomas Litman, Daniel Hägi‐Pedersen, Ismail Gögenur   +9 more
wiley   +1 more source

Role of the Transcriptional Repressor BCL6 in Allergic Response and Inflammation

World Allergy Organization Journal, 2008
Various molecules participate in different phases of allergic reactions. This means that many genes are encoding molecules related to allergic reactions, such as cytokines, chemokines, and their receptors as effector molecules.
Masafumi Arima, Takeshi Fukuda, Takeshi Tokuhisa   +2 more
doaj   +1 more source

Early growth response genes 2 and 3 regulate the expression of Bcl6 and differentiation of T follicular helper cells [PDF]

, 2015
T follicular helper (Tfh) cells support differentiation of B cells to plasma cells and high affinity antibody production in germinal centers (GC) and Tfh differentiation requires the function of B cell lymphoma 6 (Bcl6). We have now discovered that early
Alistair L.J. Symonds, Allen, Ane Ogbe, Bauquet, Becky Omodho, Bollig, Carvalho, Choi, Chtanova, Crotty, Crotty, Dent, Hao, Harris, Hothorn, Huang, Ise, Johnston, Johnston, Kwon, Li, Liu, Liu, Ma, Nakayamada, Nurieva, Nurieva, Ovcharenko, Ping Wang, Punamdip Bhullar, Qi, R Core Team, Randeep Singh, Safford, Shaffer, Sofra, Suling Li, Tizong Miao, Vinuesa, Wickham, Ye, Yu, Zhu   +42 more
core   +1 more source

The Atypical and Suspicious for Malignancy Categories of the WHO Reporting System for Lymph Node, Spleen, and Thymus Cytopathology: Review of their Diagnostic Utility, Limitations, and Clinical Impact

Diagnostic Cytopathology, Volume 54, Issue 6, Page 449-460, June 2026.
ABSTRACT Background Fine‐needle aspiration biopsy (FNAB) is the preferred first‐line diagnostic tool for evaluating lymphadenopathy due to its minimally invasive nature and cost‐effectiveness. However, cytopathological interpretation of lymph node FNAB remains challenging because of the wide morphological spectrum of lymphoid lesions.
Immacolata Cozzolino, Mats Ehinger, Oscar Lin, Elisabetta Maffei, Pio Zeppa, Andrew S. Field   +5 more
wiley   +1 more source

An essential EBV latent antigen 3C binds Bcl6 for targeted degradation and cell proliferation.

PLoS Pathogens, 2017
The latent EBV nuclear antigen 3C (EBNA3C) is required for transformation of primary human B lymphocytes. Most mature B-cell malignancies originate from malignant transformation of germinal center (GC) B-cells.
Yonggang Pei, Shuvomoy Banerjee, Hem Chandra Jha, Zhiguo Sun, Erle S Robertson   +4 more
doaj   +1 more source