Results 91 to 100 of about 22,830 (227)
Cytokine Profiles in Myasthenia Gravis Subgroups and the Lack of Any Effect of Immunosuppression
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims Myasthenia gravis (MG) is a clinically and immunologically heterogeneous autoimmune disease and there is little known about the differential effects of cytokines in disease subgroups. This study aimed to compare serum cytokine profiles across distinct MG subgroups, including early‐onset MG (EOMG), late‐onset MG (LOMG), muscle‐
Merve Cebi +6 more
wiley +1 more source
Characterizing Novel Interactions of Transcriptional Repressor Proteins BCL6 and BCL6B [PDF]
, 2017 B-cell Lymphoma 6 (BCL6) and its close homolog BCL6B encode proteins that are members of the BTB-Zinc Finger family of transcription factors. BCL6 plays an important role in regulating the differentiation and proliferation of B-cells during the adaptive ...
Lundell-Smith, Geoffrey Graham
core +3 more sources
Chromosomal translocations involving BCL6 in MALT lymphoma
Haematologica, 2008 Chromosomal translocations involving BCL6 were detected in 7 out of 392 cases of MALT lymphoma by interphase fluorescence in situ hybridisation with a BCL6 break-apart probe.
Hongtao Ye +5 more
doaj +1 more source
Inhibition of doxorubicin-induced senescence by PPARδ activation agonists in cardiac muscle cells: cooperation between PPARδ and Bcl6. [PDF]
PLoS ONE, 2012 Senescence and apoptosis are two distinct cellular programs that are activated in response to a variety of stresses. Low or high doses of the same stressor, i.e., the anticancer drug doxorubicin, may either induce apoptosis or senescence, respectively ...
Paola Altieri +7 more
doaj +1 more source
Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang +3 more
wiley +1 more source
Effects of BCL6 on Oat1- and Oat3-promoter activity. [PDF]
, 2012 OK cells were either transfected with pcDNA3 or pcDNA3-BCL6, and BCL6 expression and cellular localization were analyzed using immunofluorescence staining (green color BCL6, blue color DAPI staining; excitation wavelength 488 nm and 365 nm) (5A ...
Birgitta Christina Burckhardt (170394) +3 more
core +1 more source
PLoS ONE, 2020 The prognosis for people with the high-grade brain tumor glioblastoma is very poor, due largely to low cell death in response to genotoxic therapy. The transcription factor BCL6, a protein that normally suppresses the DNA damage response during immune ...
Marie-Sophie Fabre +12 more
doaj +1 more source
Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling
Cell Reports, 2020 Summary: The germinal center (GC) reaction is essential for long-lived humoral immunity. However, molecular requirements for the induction of Bcl6, the master regulator for GC B cell differentiation, remain unclear.
Kei Haniuda +2 more
doaj +1 more source
Andrology, EarlyView.ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam +7 more
wiley +1 more source
Bcl6 deficiency decreases expression of Chrebp in liver. [PDF]
, 2014 mRNA from liver of Bcl6 KO and WT mice was analyzed by qpcr for expression of Chrebp, GK, L-PK, and Srebp1c mRNA. Bars show the mean+SE for 4 Bcl6 KO and 4 WT mice.
Jessica Schwartz (571787) +3 more
core +1 more source