Results 111 to 120 of about 35,489 (280)

t(3;3)(q27;q27) ST6GAL1/BCL6 - del(3)(q27q27) ST6GAL1/BCL6 [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on t(3;3)(q27;q27) ST6GAL1/BCL6 - del(3)(q27q27) ST6GAL1/BCL6, with data on clinics, and the genes involved.
openaire   +2 more sources

DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi, Fei Li, Heng Jiang, Lingling Gu, Mengjie Sun, Kunyu Lu, Pianpian Liu, Ruyue Xie, Wenqiang Ma, Meijuan Zheng, Xianwei Wang, Xuefu Wang, Jingjing Cong   +12 more
wiley   +1 more source

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory [PDF]

, 2012
One component of memory in the antibody system is long-lived memory B cells selected for the expression of somatically mutated, high-affinity antibodies in the T cell–dependent germinal center (GC) reaction.
Hijikata, Atsushi, Hikida, Masaki, Ishige, Akiko, Kaji, Tomohiro, Kubo, Masato, Kurosaki, Tomohiro, Nagashima, Takeshi, Ohara, Osamu, Okada, Mariko, Rajewsky, Klaus, Taka, Junko, Takahashi, Yoshimasa, Takemori, Toshitada   +12 more
core   +2 more sources

Single Cell RNA Transcriptomics of Mantle Cell Lymphoma Reveals the Presence of Treatment‐Resistant Subclones at the Time of Diagnosis

American Journal of Hematology, Volume 101, Issue 5, Page 1025-1035, May 2026.
ABSTRACT Mantle cell lymphoma (MCL) is a B‐cell malignancy with a chronically relapsing clinical course and pronounced genetic heterogeneity. To investigate the clonal dynamics underlying early disease relapse, we performed single‐cell RNA sequencing of paired tumor samples collected at diagnosis and at first relapse. Inference of copy number variants (
Dmitry Manakov, Magdalena Klanova, Michal Kolar, Robert Ivanek, Florian Geier, Julien Roux, Tomas Zikmund, Lucie Winkowska, Eva Kriegova, Jirina Manakova, Liliana Tuskova, Silvia Spanikova, Alexandra Scasna, Marek Trneny, Pavel Klener   +14 more
wiley   +1 more source

The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program [PDF]

, 2015
SummaryThe pathways regulating formation of the germinal center (GC) dark zone (DZ) and light zone (LZ) are unknown. In this study we show that FOXO1 transcription factor expression was restricted to the GC DZ and was required for DZ formation, since its
Achille Kouatchet, Adrien Mirouse, Anne Renault, Anne-Pascale Meert, Antoine Rabbat, Christine Lebert, Djamel Mokart, Dominique Benoit, Elie Azoulay, Fabrice Bruneel, François Vincent, Frédéric Pène, Julien Mayaux, Martine Nyunga, Matthieu Resche-Rigon, Mercé Jourdain, Michaël Darmon, on behalf of the Groupe de Recherche sur la Réanimation Respiratoire en Onco-Hématologie (Grrr-OH), Pierre Perez, Rebecca Hamidfar, Virginie Lemiale   +20 more
core   +3 more sources

Data from Prolactin Inhibits BCL6 Expression in Breast Cancer through a Stat5a-Dependent Mechanism

, 2023
Thai H. Tran, Fransiscus E. Utama, Justin Yifu Lin, Ning Yang, Ashley B. Sjolund, Amy Ryder, Kevin Johnson, Lynn M. Neilson, Chengbao Liu, Kristin L. Brill, Anne Rosenberg, Agnieszka K. Witkiewicz, Hallgeir Rui   +12 more
openalex   +1 more source

Primary Cardiac Lymphoma: A Diagnostically Challenging Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT This case highlights the diagnostic difficulties of PCL, including non‐specific symptoms, imaging mimics, and the critical role of histopathological confirmation despite technical and clinical challenges. Early multidisciplinary evaluation is essential to improve outcomes in this aggressive disease.
Yucheng Huang, Minxi Lao, Min Ye, Yang Yang, Meilin Ding, Jin Li, Lei Su   +6 more
wiley   +1 more source

Adverse Prognostic Significance of Activation‐Induced Cytidine Deaminase in Diffuse Large B‐Cell Lymphoma Patients Treated With R‐CHOP

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background A number of studies have demonstrated the important role of activation‐induced cytidine deaminase (AID) in the pathogenesis of diffuse large B‐cell lymphoma (DLBCL). AID has been relatively underexplored as a prognostic factor in DLBCL, and its role remains controversial.
Mardiah Suci Hardianti, Nungki Anggorowati, Syahru Agung Setiawan, Miraz Radhea Bagaskoro, Johan Kurnianda, Kartika Widayati Taroeno‐Hariadi, Ibnu Purwanto, Susanna Hilda Hutajulu   +7 more
wiley   +1 more source

Photoenzymatic Hydroalkylation Enables Streamlined Access to Aryl Glutarimide Precursors

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
We report a photoenzymatic hydroalkylation that enables streamlined, stereocontrolled access to aryl glutarimide precursors relevant to targeted protein degradation. Engineered flavin‐dependent “ene”‐reductases provide broad scope and high enantioselectivity through a distinct electron transfer–enantioselective proton transfer pathway.
Zhi Xu, Prasun Mukherjee, Steven Gossert, Stephen Thomas, Vasil H. Vasilev, Eric R. Welin, Yichen Tan, Shane M. McKenna, Megan A. Emmanuel, Todd K. Hyster   +9 more
wiley   +2 more sources

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source