Results 111 to 120 of about 22,830 (227)
Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez +8 more
wiley +1 more source
ABSTRACT Crystal‐storing histiocytosis (CSH) is a rare histopathologic phenomenon characterized by the accumulation of crystalline material within histiocytes, most often associated with lymphoplasmacytic or plasma cell neoplasms. Cutaneous involvement is uncommon and may present diagnostic challenges.
Liangli Wang +8 more
wiley +1 more source
Drug Research in Inhibiting BCL6 in Ovarian Cancer [PDF]
Ovarian cancer has a survival rate of 50 percent just five years after being diagnosed (Nguyen et al. 2020). Finding new ways to treat ovarian cancer is important to increase the survival of patients who have been diagnosed.
Beek, Quinn E, Walker, Sarah
core +1 more source
BCL6 is expressed in glioblastoma tumors and cell lines. [PDF]
A. Proportion of BCL6+ cells in 62 human GBM tumors (top), and representative IHC staining of 2 of 62 human GBM tumors, highlighting heterogeneous BCL6 protein (brown staining). B. BCL6+ GBM tumors after stratification by IDH1 mutation (top) p53 mutation
Melanie J. McConnell (4413490) +12 more
core +1 more source
Role of the Transcriptional Repressor BCL6 in Allergic Response and Inflammation
Various molecules participate in different phases of allergic reactions. This means that many genes are encoding molecules related to allergic reactions, such as cytokines, chemokines, and their receptors as effector molecules.
Masafumi Arima +2 more
doaj +1 more source
Bone Marrow Pathology in Cold Agglutinin‐Mediated Autoimmune Hemolytic Anemia: A Study of 56 Cases
ABSTRACT Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia (AIHA). CAD occurs in the context of a small clonal B‐cell lymphoproliferation restricted to blood and/or bone marrow (BM), without overt or extramedullary lymphoma. The WHO‐HAEM5 introduced a description of the CAD‐associated lymphoproliferative disorder (CAD‐LPD) in ...
Anne‐Marie L. Becking +6 more
wiley +1 more source
BCL6 (B-Cell Lymphoma 6) [PDF]
Review on BCL6 (B-Cell Lymphoma 6), with data on DNA, on the protein encoded, and where the gene is ...
Knezevich, S
core +1 more source
An essential EBV latent antigen 3C binds Bcl6 for targeted degradation and cell proliferation.
The latent EBV nuclear antigen 3C (EBNA3C) is required for transformation of primary human B lymphocytes. Most mature B-cell malignancies originate from malignant transformation of germinal center (GC) B-cells.
Yonggang Pei +4 more
doaj +1 more source
Background The poor outcome of high-grade B-cell lymphoma, with rearrangements of MYC, BCL2 and/or BCL6, also known as double-hit lymphoma or triple-hit lymphoma (DHL or THL), has been well documented, while the clinical significance of extra copies of ...
Sixia Huang +9 more
doaj +1 more source
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley +1 more source

