Molecular mechanisms in haematological malignancies [PDF]
Haematopoiesis requires the constant production of large numbers of peripheral blood cells. This process is under tight control of transcription factor networks as well as cytokines, growth factors and hormones.
Avellino, Roberto +2 more
core
Integrating Flow Cytometry in the Diagnostic Work of HIV‐Associated Hodgkin's Lymphomas
ABSTRACT Hodgkin lymphoma (HL) is prevalent worldwide and typically presents symptoms like sudden pain, swelling, and weight loss. Classical HL (cHL) is largely treatable with modern risk‐adapted and response‐based therapy. cHL represents one of the most common malignancies occurring during the course of evolution in patients living with HIV.
Maria Santa +23 more
wiley +1 more source
The survival impact of combined expression of myc, bcl2 and bcl6 in diffuse large b cell lymphoma patients [PDF]
Introduction. C-MYC is one of the essential transcription factors that play a role in various cellular functions. The MYC rearrangement is associated with low overall survival and low progression-free survival, increased risk of central nervous system ...
Adelina BIRCEANU COROBEA +7 more
doaj
A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo [PDF]
Leandro Cerchietti +7 more
openalex +1 more source
Memory B Cells without Somatic Hypermutation Are Generated from Bcl6-Deficient B Cells [PDF]
Hirochika Toyama +8 more
openalex +1 more source
Primary thyroid lymphomas commonly originate from a background of Hashimoto’s thyroiditis and comprise largely extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (EMZL), diffuse large B-cell lymphoma (DLBCL), and follicular lymphoma (
Maria-Myrsini Tzioni +15 more
doaj +1 more source
Extreme Peripheral Blood Plasmacytosis Mimicking Plasma Cell Leukemia as a Presenting Feature of Angioimmunoblastic T-Cell Lymphoma (AITL). [PDF]
Angioimmunoblastic T-cell lymphoma (AITL) is one of four major subtypes of nodal peripheral T cell lymphoma, characterized by its cell of origin, the follicular helper T-cell (TFH).
Alpdogan, Onder +7 more
core +1 more source
Regulation of BCL6: p38 MAPK signalling and CTCF transcriptional regulation converge at exon 1
BCL6 is a zinc finger transcriptional repressor, which is highly expressed in germinal centre B-cells, and is essential for germinal centre formation and T-dependent antibody responses.
Batlle, Ana, Batlle, Ana
core +1 more source
The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination. [PDF]
The orphan Gα13-coupled receptor P2RY8 is mutated in human germinal center (GC)-derived lymphomas and was recently found to promote B cell association with GCs in a mouse model. Here we establish that P2RY8 promotes clustering of activated B cells within
Cyster, Jason G +2 more
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