Results 31 to 40 of about 22,830 (227)

Alternative splicing generates a short BCL6 (BCL6S) isoform encoding a compact repressor [PDF]

Biochemical and Biophysical Research Communications, 2008
BCL6 gene transcribes two main mRNA isoforms, variant 1 and variant 2, which have distinct transcription start sites. However, these two isoforms encode identical BCL6 protein. Recently, a third variant was sequenced from a human hippocampus cDNA library (DB465062). In this study, we cloned and sequenced a novel BCL6 spliced isoform (BCL6S) which lacks
Yulei, Shen, Baosheng, Ge, Himabindu, Ramachandrareddy, Timothy, McKeithan, Wing C, Chan   +4 more
openaire   +2 more sources

B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36

Cell Death and Disease, 2022
Nonalcoholic fatty liver disease (NAFLD) is an ubiquitous disease that exists across a wide spectrum ranging from steatosis, steatohepatitis, advanced fibrosis, and liver cirrhosis.
Hao Zhang, Yue Li, Chao Zhang, Kun Huang, Jing Zhao, Sheng Le, Lang Jiang, Hao Liu, Peiwen Yang, Xiaoyue Xiao, Jizhang Yu, Jie Wu, Ping Ye, Jiahong Xia   +13 more
doaj   +1 more source

Convergent BCL6 and lncRNA promoters demarcate the major breakpoint region for BCL6 translocations [PDF]

Blood, 2015
To the editor: We recently published a study showing that BCL6 translocations occur at distinct sequence motifs within intron 1 of the BCL6 gene that are recognized and deaminated by activation-induced cytidine deaminase (AID).[1][1] It has been unclear, however, why these breakpoints cluster in ...
Zhengfei, Lu, Nicholas R, Pannunzio, Harvey A, Greisman, David, Casero, Chintan, Parekh, Michael R, Lieber   +5 more
openaire   +2 more sources

Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6

OncoImmunology, 2020
We developed a therapeutic, gene-modified, allogeneic melanoma vaccine (AGI-101H), which, upon genetic modification, acquired melanoma stem cell-like phenotype.
Patrycja Czerwinska, Marcin Rucinski, Nikola Wlodarczyk, Anna Jaworska, Iga Grzadzielewska, Katarzyna Gryska, Lukasz Galus, Jacek Mackiewicz, Andrzej Mackiewicz   +8 more
doaj   +1 more source

Interleukin-19 promotes bone resorption by suppressing osteoprotegerin expression in BMSCs in a lipopolysaccharide-induced bone loss mouse model

Bone & Joint Research, 2023
Aims: Osteoporosis is characterized by decreased trabecular bone volume, and microarchitectural deterioration in the medullary cavity. Interleukin-19 (IL-19), a member of the IL-10 family, is an anti-inflammatory cytokine produced primarily by ...
Zhicheng Dai, Yanan Chen, Enjun He, Hongjie Wang, Weihong Guo, Zhenkai Wu, Kai Huang, Qinghua Zhao   +7 more
doaj   +1 more source

AID assists DNMT1 to attenuate BCL6 expression through DNA methylation in diffuse large B-cell lymphoma cell lines

Neoplasia: An International Journal for Oncology Research, 2020
The BCL6 proto-oncogene encodes a transcriptional repressor, which is required for germinal centers (GCs) formation and lymphomagenesis. Previous studies have been reported that the constitutive expression of BCL6 leads to diffuse large B cell lymphoma ...
Junna Jiao, Zhuangwei Lv, Ping Zhang, Yang Wang, Meng Yuan, Xiaozhuo Yu, Woodvine Otieno Odhiambo, Mingzhe Zheng, Hua Zhang, Yunfeng Ma, Yanhong Ji   +10 more
doaj   +1 more source

Assembling defenses against therapy-resistant leukemic stem cells: Bcl6 joins the ranks [PDF]

, 2011
The resistance of leukemic stem cells in response to targeted therapies such as tyrosine kinase inhibitors (TKIs) relies on the cooperative activity of multiple signaling pathways and molecules, including TGFβ, AKT, and FOXO transcription factors ...
Holyoake, T.L., Tessa L. Holyoake, Pellicano, F., Francesca Pellicano   +3 more
core   +1 more source

BCL6 breaks occur at different AID sequence motifs in Ig–BCL6 and non-Ig–BCL6 rearrangements

Blood, 2013
Key Points Chromosomal breaks in BCL6 translocations occur at two distinct DNA sequence motifs associated with AID activity. Motif usage correlates with the type of BCL6 partner gene, suggesting mechanistic differences between Ig–BCL6 and non-Ig–BCL6 rearrangements.
Zhengfei, Lu, Albert G, Tsai, Takashi, Akasaka, Hitoshi, Ohno, Yanwen, Jiang, Ari M, Melnick, Harvey A, Greisman, Michael R, Lieber   +7 more
openaire   +3 more sources

Prevalence and Prognostic Impact of MYC, BCL2, and BCL6 Rearrangements in Large B Cell Lymphoma Patients: A Multicenter Historical Cohort Study from Iran [PDF]

Middle East Journal of Cancer
Background: Diffuse large B cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin's lymphoma, characterized by remarkable molecular heterogeneity.
Fatemeh Radmanesh, Ahmad Monabati, Maedeh Motavas, Alireza Rezvani, Mehdi Montazer   +4 more
doaj   +1 more source

Identification of zinc finger protein Bcl6 as a novel regulator of early adipose commitment [PDF]

Open Biology, 2016
Adipose tissue is a key determinant of whole-body metabolism and energy homeostasis. Unravelling the transcriptional regulatory process during adipogenesis is therefore highly relevant from a biomedical perspective.
Xiaoming Hu, Yuanfei Zhou, Yang Yang, Jie Peng, Tongxing Song, Tao Xu, Hongkui Wei, Siwen Jiang, Jian Peng   +8 more
doaj   +1 more source