Results 31 to 40 of about 35,489 (280)

Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production [PDF]

, 2017
IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells.
Cherukur, Yesesri, Dent, Alexander L., Hummel, Sarah A., Janga, Sarath Chandra, Kaplan, Mark H., Khan, Ibrahim, Meuris, Brice, Olson, Matthew R., Ulrich, Benjamin J.   +8 more
core   +1 more source

BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer

The Journal of Clinical Investigation, 2022
Mutational activation of KRAS is a common oncogenic event in lung cancer, yet effective therapies are still lacking. Here, we identify B cell lymphoma 6 (BCL6) as a lynchpin in KRAS-driven lung cancer.
Kun Li, Yanan Liu, Yi Ding, Zhengwei Zhang, Juanjuan Feng, Jiaxin Hu, Jiwei Chen, Zhengke Lian, Yiliang Chen, Kewen Hu, Zhi Chen, Zhenyu Cai, Mingyao Liu, Xiufeng Pang   +13 more
doaj   +1 more source

Lower Bounds on Mutual Information [PDF]

, 2010
We correct claims about lower bounds on mutual information (MI) between real-valued random variables made in A. Kraskov {\it et al.}, Phys. Rev. E {\bf 69}, 066138 (2004). We show that non-trivial lower bounds on MI in terms of linear correlations depend
David V. Foster, M. Li, Peter Grassberger, T. M. Cover, W. H. Press   +4 more
core   +2 more sources

Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas. [PDF]

, 2020
MYC-driven lymphomas, especially those with concurrent MYC and BCL2 dysregulation, are currently a challenge in clinical practice due to rapid disease progression, resistance to standard chemotherapy, and high risk of refractory disease.
Bi, Chengfeng, Brown, Lauren E., Devine, William G., Fu, Kai, Hao, Xinbao, Huang, Yuhua, Lu, Ting, Lunning, Matthew, Porco, John A., Tian, Tian, Vose, Julie, Wang, Cheng, Yue, Ting, Zhang, Weiwei, Zhang, Xiaoyan, Zhang, Xuan   +15 more
core   +1 more source

A lesson for cancer research : placental microarray gene analysis in preeclampsia [PDF]

, 2012
Tumor progression and pregnancy share many common features, such as immune tolerance and invasion. The invasion of trophoblasts in the placenta into the uterine wall is essential for fetal development, and is thus precisely regulated.
Louwen, Frank, Muschol-Steinmetz, Cornelia, Reinhard, Joscha, Reitter, Anke, Yuan, Juping   +4 more
core   +2 more sources

Allergic TH2 Response Governed by B-Cell Lymphoma 6 Function in Naturally Occurring Memory Phenotype CD4+ T Cells

Frontiers in Immunology, 2018
Transcriptional repressor B-cell lymphoma 6 (Bcl6) appears to regulate TH2 immune responses in allergies, but its precise role is unclear. We previously reported that Bcl6 suppressed IL-4 production in naïve CD4+ T cell-derived memory TH2 cells.
Takashi Ogasawara, Yuko Kohashi, Jun Ikari, Toshibumi Taniguchi, Nobuhide Tsuruoka, Haruko Watanabe-Takano, Lisa Fujimura, Akemi Sakamoto, Masahiko Hatano, Hirokuni Hirata, Yasutsugu Fukushima, Takeshi Fukuda, Kazuhiro Kurasawa, Koichiro Tatsumi, Takeshi Tokuhisa, Masafumi Arima, Masafumi Arima   +16 more
doaj   +1 more source

The malignancy suppression and ferroptosis facilitation of BCL6 in gastric cancer mediated by FZD7 repression are strengthened by RNF180/RhoC pathway

Cell & Bioscience, 2023
Background B-cell lymphoma 6 (BCL6) is a transcription repressor that plays a tumor suppressor or promoting role in various tumors. However, its function and molecular mechanism in gastric cancer (GC) remain unclear.
Shiwei Guo, Jingyu Deng, Pengliang Wang, Fan Kou, Zizhen Wu, Nannan Zhang, Zhenzhen Zhao, Yongzhan Nie, Lili Yang   +8 more
doaj   +1 more source

The transcriptional repressor Bcl6 controls the stability of regulatory T cells by intrinsic and extrinsic pathways [PDF]

, 2015
Foxp3(+) regulatory T (Treg) cells are essential to maintain immune homeostasis, yet controversy exists about the stability of this cell population. Bcl6-deficient (Bcl6(-/-) ) mice develop severe and spontaneous T helper type 2 (Th2) inflammation and ...
Dent, Alexander L., Kaplan, Mark H., Sawant, Deepali V., Sehra, Sarita, Wu, Hao, Yao, Weiguo   +5 more
core   +1 more source

HBV messing with the B-cell genome leads to DLBCL [PDF]

, 2018
non ...
Casato, Milvia, Visentini, Marcella
core   +1 more source

Hit-and-run lymphomagenesis by theBcl6oncogene [PDF]

Cell Cycle, 2014
Editorials: Cell Cycle ...
Green, Michael R., Vicente-Dueñas, Carolina, Alizadeh, Ash A., Sánchez García, Isidro   +3 more
openaire   +3 more sources