Results 161 to 170 of about 134,892 (289)

Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgenic mice

Neuroprotection, EarlyView.
Downregulation of the expression of silent information regulator sirtuin 1 (SIRT1) exacerbates neuronal degeneration and loss by activating forkhead box O1 (FOXO1) acetylation and promoting endoplasmic reticulum stress (ERSA)‐mediated apoptosis in aging.
Nan Zhang, Zongyuan Zhao, Xiaoxiao Chen, Hanbing Yao, Min Zhu, Shuqing Ma, Hui Wang, Xianghong Yin, Ying Zhou, Chenfei Zheng, Jianmin Li, Jingye Pan, Kaicheng Wang, Bin Yang, Yunting Wang, Junming Fan, Yongsheng Gong, Rong Liu, Jing Zeng, Xiaofang Fan, Yangping Shentu   +20 more
wiley   +1 more source

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection, EarlyView.
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley   +1 more source

Tumor Hypoxia and CD8+ T‐Cell Infiltration in Patients With Advanced Laryngeal Cancer

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective We assessed correlations between tumor carbonic anhydrase IX (CAIX) staining, as a marker of tumor hypoxia, and CD8+ T‐cell infiltration in a cohort of patients with advanced laryngeal squamous cell carcinoma undergoing a bioselection approach for definitive treatment. Study Design Retrospective cohort study.
Joshua D. Smith, Elizabeth Gensterblum‐Miller, David W.A. Forner, Pratyusha Yalamanchi, Marisa R. Buchakjian, Steven B. Chinn, Andrew G. Shuman, Keith A. Casper, Kelly M. Malloy, Chaz L. Stucken, Scott A. Mclean, Michelle L. Mierzwa, Jennifer Shah, Paul L. Swiecicki, Francis P. Worden, Mark E.P. Prince, Matthew E. Spector, J. Chad Brenner, Molly E. Heft Neal   +18 more
wiley   +1 more source

Expression Profile of Apoptotic Genes Bak1 and Bcl2 in Pakistani Presbycusis Patients from Faisalabad and Chichawatni Populations

JLUMHS
OBJECTIVE: To analyze the expression profiles of two apoptotic genes, BAK1 and BCL2, in Pakistani ARHI patients' blood samples compared to healthy subjects.
Abdul Rauf, Rashid Bhatti, Saleeha Kausar, Sehar Aslam, Nazia Nahid, Muhammad Qasim   +5 more
doaj   +1 more source

The Effect of Aerobic Training and L- Carnitine on BCL2 and Mitochondrial Enzymes of Rat\'s Kidney

Iranian Journal of Diabetes and Obesity, 2019
Objective: Diabetes causes free radical production, oxidative stress and alterations in mitochondrial enzymes and apoptosis. The purpose of this study was to investigate the effect of aerobic exercise and consumption of L-carnitine on BCL2 and some ...
Ali Fakourian, Homaee Hasan Matin, Mohammad Ali Azarbayjani, Parvin Farzanegi   +3 more
doaj  

Resistance mechanisms and clonal dynamics in mantle cell lymphoma treated with sequential BTKi and venetoclax therapy

The Journal of Pathology, EarlyView.
Abstract In recent years, targeted therapies have become the standard of care for refractory/relapsed mantle cell lymphoma (MCL). Although the mutational profile of MCL has been extensively studied, there is a lack of understanding of resistance mechanisms and genetic factors that impact the response to novel treatments.
Tamás László, László Imre Pinczés, Bence Bátai, Luca Varga, Botond Timár, Anita Gulyás, Ilona Tárkányi, Márk Plander, Zsolt Nagy, Péter Rajnics, Miklós Egyed, Zsuzsa Molnár, János Rottek, András Masszi, Péter Tamáska, Róbert Szász, Árpád Illés, Donát Alpár, Ferenc Magyari, Csaba Bödör   +19 more
wiley   +1 more source

Accelerating Drug Development for Neuroblastoma: Consensus Statement From the Third Neuroblastoma Drug Development Strategy Forum

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma is a poor prognosis cancer of the sympathetic nervous system that accounts for a disproportionate number of childhood cancer deaths. Many viable biological targets have been identified, and the number of potential combinations is even larger.
Steven G. DuBois, Lucas Moreno, John Anderson, Shahab Asgharzadeh, Ro Bagatell, Maja Beck‐Popovic, Jen Belle, Pablo Berlanga, Nick J. Bird, Louis Chesler, Adam Durbin, Angelika Eggert, Martin Eilers, Sara M. Federico, Matthias Fischer, Susanne A. Gatz, Rani E. George, Sally George, Kelly C. Goldsmith, Juliet Gray, Andras Heczey, Meredith S. Irwin, Leona Knox, Holger N. Lode, Donna Ludwinski, Margaret E. Macy, Robbie G. Majzner, John M. Maris, Shakeel Modak, Jan J. Molenaar, Daniel A. Morgenstern, Yael P. Mossé, Cormac Owens, C. Patrick Reynolds, Claudia Rossig, Gudrun Schleiermacher, Liz Scott, Paul M. Sondel, Frank Speleman, Max van Noesel, Frank Westermann, Judith Wienke, Adam J. Wolpaw, Julie R. Park, Andrew D. J. Pearson   +44 more
wiley   +1 more source

Therapeutic Effects of Phyllanthus urinaria L on Cisplatin‐Induced Acute Kidney Injury: Anti‐Inflammatory, Anti‐Apoptotic, and Anti‐Oxidative Action

Pediatric Discovery, EarlyView.
Phyllanthus urinaria L can alleviate cisplatin‐induced acute kidney injury by inhibiting inflammation, apoptosis and oxidative stress. ABSTRACT Acute kidney injury (AKI) is a prevalent and serious clinical challenge with limited specific treatments.
Qitong Guo, Ping Li, Meiling Chen, Yihang Yu, Lianju Shen, Chunlan Long, Xing Liu, Guanghui Wei, Deying Zhang   +8 more
wiley   +1 more source

The Effect of Dracocephalum kotschyi Alcoholic Extract on the BCL2 and BAX Expression in SKBR3 Cell Line

Research in Molecular Medicine, 2019
Background: Breast cancer is the most prevalent malignancy among females worldwide, and its incidence is growing among Iranian women. Also, Iranian patients with breast cancer are younger than their Western counterparts.
Fatemeh Ketabchi, Faezeh Namazi, Nasrin Hadi, Farinaz Khosravian, Mirza mohammad Raisinia, Mansoor Salehi   +5 more
doaj  

PI3K/BCL2: illusion or promise for RS? [PDF]

Blood, 2021
openaire   +2 more sources