Results 171 to 180 of about 145,113 (281)

IAP Antagonists Selectively Eliminate Therapy‐Induced Senescent Cancer Cells via TNFα‐Independent Apoptosis

Cancer Science, EarlyView.
Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Hiroaki Ochiiwa, Takeshi Wakasa, Yuki Kataoka, Koji Ando, Eiji Oki, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao   +7 more
wiley   +1 more source

Defying the odds: A rare case of primary breast double-hit lymphoma with remarkable remission. [PDF]

SAGE Open Med Case Rep
Alsaket LZ, Elkourashy SA, Kolleri J, Alobadli AM.   +3 more
europepmc   +1 more source

BCL2 Gene Rearrangement [PDF]

, 2020
openaire   +1 more source

NOL7 Inhibits Ovarian Cancer Progression and Suppresses Angiogenesis by Stabilizing GADD45A to Deactivate STAT3

Cancer Science, EarlyView.
NOL7 acts as a tumor‐suppressor in ovarian cancer. Overexpression of NOL7 up‐regulated GADD45A expression by stabilizing GADD45A mRNA in ovarian cancer cells. ABSTRACT Ovarian cancer is one of the most prevalent gynecologic malignancies worldwide. Dysregulated cell proliferation and angiogenesis are well‐recognized to be involved in the pathogenesis of
Xinyu Xu, Jiayuan Wang, Meng Jiang, Ling Ouyang   +3 more
wiley   +1 more source

HDAC3 inhibition as a therapeutic strategy in T-cell acute lymphoblastic leukemia via the TYK2-STAT1-BCL2 signaling pathway. [PDF]

Front Immunol
Gu Z, Liu Y, Jiao Y, Wang H, Wang L, Le N, Zhang X, Liu Q, Xu Y, Liu D, Gao C, Dou L.   +11 more
europepmc   +1 more source

BCL2 Gene Translocation [PDF]

, 2020
openaire   +1 more source

Early‐Onset Digestive System Cancers: Risk Factors and Clinicopathological and Molecular Features Across Organ Sites

Cancer Science, EarlyView.
Shared risk factors, clinical features, and tumor characteristics across multiple early‐onset cancer types are shown in this Graphical Abstract. Integrative approaches combining molecular pathology, oncology, and population sciences offer opportunities to clarify underlying mechanisms and help us develop preventive strategies for early‐onset cancers ...
Nobuhiro Nakazawa, Satoko Ugai, Atsushi Kondo, Kosuke Matsuda, Shu Kato, Genki Usui, Shiori Tanaka, Hwa‐Young Lee, Xinyuan Zhang, Hideo Miyagawa, Mai Chan Lau, Hiroshi Saeki, Yukihide Kanemitsu, Andrew T. Chan, Shuji Ogino, Minkyo Song, Juha P. Väyrynen, Tomotaka Ugai   +17 more
wiley   +1 more source

Immunohistochemical Expression of BCl2 Oncoprotein in Varying Histological Grades of Oral Squamous Cell Carcinoma

Online Journal of Health & Allied Sciences
Oral cancer has been rising in alarming numbers in the world which is anticipated to escalate at 70% by 2030. Although a lot of factors are responsible for the disease, genetics, and gene mutations play a major role in uncontrolled proliferation. Another
Subhalakshmi V, Rohit Jaiswal, Indra Priyadharshini K, Ambika Murugesan   +3 more
doaj  

Exploring the toxicological impact of N-nitrosodimethylamine (NDMA) exposure on bladder urothelial carcinoma (BLCA) through network toxicology, machine learning, and multi-dimensional bioinformatics analysis. [PDF]

Discov Oncol
Shi Z, Yang X, Liu Y, Gao Y, Liu J, Wang L, Wang X.   +6 more
europepmc   +1 more source

BCL2-associated X protein (BAX); BCL2-antagonist/killer 1 (BAK1; BAK); B cell lymphoma 2 (BCL-2; BCL2); BCL2 homology domain 3 (BH3) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source