Results 121 to 130 of about 290,825 (294)

Evaluation of Morpholino Antisense Oligos’ Role on BCR-ABL Gene Silencing in the K562 Cell Line [PDF]

Cell Journal, 2010
Objective: Chronic myeloid leukemia (CML) develops when a hematopoietic stem cellacquires the BCR/ABL fusion gene. This causes these transformed hematopoietic cellsto have a greater than normal proliferation rate.
Bahman Delalat, Soraya Rasi Ghaemi, Saeid Abroun, Mehrdad Noruzinia, Mahmoud Haririan, Masoud Soleimani, Saeid Kaviani   +6 more
doaj  

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu, Jin‐Hao Chen, Yan‐Fang Wang, Xiao Wu, Hui‐Yun Ni, Qiu‐Rong Zhang   +5 more
wiley   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Efficacy of functional alignment in total knee arthroplasty in restoring in vivo cruciate ligament forces and knee kinematics compared with mechanical alignment

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose The impact of coronal alignment on cruciate ligament forces in bicruciate‐retaining total knee arthroplasty (TKA) remains unclear. We aimed to clarify in vivo cruciate ligament forces and knee kinematics among mechanically aligned (MA) and functionally aligned (FA) TKAs and normal knees.
Kenichi Kono, Hiroshi Inui, Tomofumi Kage, Takaharu Yamazaki, Shuji Taketomi, Darryl D'Lima, Tetsuya Tomita, Sakae Tanaka   +7 more
wiley   +1 more source

Diagnosis and management of biochemical recurrence in patients with prostate cancer who received definitive treatment

Urology Research and Practice, 2019
After definitive treatment, recurrence is seen in some patients, as manifested by a rise in prostate-specific antigen (PSA) before clinical progression.
Hasan Soydan, Kadir Baykal
doaj   +2 more sources

Impact of COVID‐19 and Vaccination on Lower Urinary Tract Symptoms: Insights From a Prospective Cohort Study

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims To evaluate the prevalence, clinical course, and risk factors of lower urinary tract symptoms (LUTS) in patients hospitalized with COVID‐19, and to assess associations with comorbidities, disease severity, and vaccination status. Methods We conducted a prospective cohort study of adult patients hospitalized with confirmed COVID‐19, who ...
Julia Duarte de Souza, Jose de Bessa Jr., Natássia Cristina Carboni Truzzi, Carolina Trigo Rocha, Bruno Camargo Rocha Paim de Araujo, Julyana Kanate Mazzoni Moromizato, Thulio Bosi Vieira Brandão, Rachel Mazoni Costa, Marcelo Hisano, Zein Mohamed Sammour, Homero Bruschini, William Carlos Nahas, Cristiano Mendes Gomes   +12 more
wiley   +1 more source

Simplifying species‐interaction models by grouping parameters: optimal groupings differ between effects and responses

Oikos, EarlyView.
Most ecological models of species interactions require many parameters, making them expensive to fit to experimental or observational data. To reduce the number of parameters, species are often divided into groups a priori, for example on the basis of functional or phylogenetic similarity, and species within these groups are assumed to behave ...
Christopher R. P. Brown, Daniel B. Stouffer   +1 more
wiley   +1 more source

Integrating indigenous crops in agroforestry systems: Lesser yam and teak mixed systems are more profitable than monocultures in Indonesia

PLANTS, PEOPLE, PLANET, EarlyView.
Major staple crops are often introduced and cultivated in monocultures. Yams are staple crops native to the majority of low‐ and middle‐income countries and can provide an alternative to introduced staple crops. We showed that lesser yams cultivated together with teak trees (planted at the border of the farm) are more profitable than lesser yam ...
Budiadi, Sawitri, Enggal Primananda, Aqmal Nur Jihad, Marco Campera, Rika Bela Rahmawati   +5 more
wiley   +1 more source

Association and risk of blood urea nitrogen-to-creatinine ratio with congestive heart failure in critically ill COPD patients

BMC Pulmonary Medicine
Objective Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and death. The blood urea nitrogen-to-creatinine ratio (BCR) is recognized as a crucial marker to assess renal function and cardiovascular risk.
Jinjun Sun, Weiwei Chen, Hongli Xu
doaj   +1 more source

Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer

The Prostate, EarlyView.
ABSTRACT Background The management of intermediate‐risk early prostate cancer (PCa) is challenging due to the difficulty in distinguishing indolent from aggressive tumors. This study explores the association between genomic alterations and the tumor and its microenvironment (TME) and implications for disease progression. Methods We performed multi‐omic
William Lautert‐Dutra, Camila M. Melo, Luiz P. Chaves, Francisco C. Souza, Vida Talebian, Cheryl Crozier, Mary Anne Quintayo, Linda Liao, Dan Dion, Fabiano P. Saggioro, Felipe S. Avante, Rodolfo B. dos Reis, Jeremy A. Squire, Jane Bayani   +13 more
wiley   +1 more source