Results 101 to 110 of about 179,498 (360)

Evaluation of Mobility, Bioavailability and Toxicity of Pb and Cd in Contaminated Soil Using TCLP, BCR and Earthworms [PDF]

open access: gold, 2014
Maria Luíza Félix Marques Kede   +6 more
openalex   +1 more source

Farming in the shadows of Rome: A multi‐proxy palaeoenvironmental record from Loch Clunie—Perthshire

open access: yesJournal of Quaternary Science, EarlyView.
ABSTRACT Roman impacts on local society is a subject of international significance. Loch Clunie, Perthshire, lies only 5.4 km from Inchtuthil, the only Roman legionary fortress in Scotland, and contains two crannogs and a probable lakeside hillfort. Despite this proximity and the likelihood of local–Roman interaction, these sites remain unexcavated ...
Samantha E. Jones   +6 more
wiley   +1 more source

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu   +5 more
wiley   +1 more source

Inhibition of autoantigen-induced B-cell receptor (BCR) internalization as a therapeutic strategy in diffuse large B cell lymphoma (DLBCL)

open access: yesCell Death and Disease
BCR signal dependency is a hallmark of diffuse large B-cell lymphoma (DLBCL) and other B-cell lymphoid malignancies originating from germinal centers. Chronic-active BCR signaling, typical for the more aggressive activated B-cell subtype (ABC) of DLBCLs,
Patryk Górniak   +11 more
doaj   +1 more source

Immunocytochemical study of Bcr and Bcr-Abl localization in K562 cells.

open access: yesExperimental oncology, 2010
To obtain polyclonal antibodies against recombinant proteins recognizing Bcr domain and fusion region of Bcr-Abl and analyze the patterns of intracellular distribution of Bcr and Bcr-Abl proteins in K562 cells of chronic myelogenous leukemia.The coding sequences of DH and PH domains of Bcr-Abl were cloned, and the recombinant proteins were expressed in
Telegeev, G.D.   +6 more
openaire   +2 more sources

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa   +2 more
wiley   +1 more source

Efficacy and safety of low-dose imatinib in an elderly patient with mixed phenotype acute leukemia with t(9;22)(q34;q11.2);BCR-ABL1 [PDF]

open access: gold, 2020
Yusuke Okayama   +7 more
openalex   +1 more source

Efficacy of functional alignment in total knee arthroplasty in restoring in vivo cruciate ligament forces and knee kinematics compared with mechanical alignment

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose The impact of coronal alignment on cruciate ligament forces in bicruciate‐retaining total knee arthroplasty (TKA) remains unclear. We aimed to clarify in vivo cruciate ligament forces and knee kinematics among mechanically aligned (MA) and functionally aligned (FA) TKAs and normal knees.
Kenichi Kono   +7 more
wiley   +1 more source

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