Results 91 to 100 of about 179,498 (360)
Implications of BCR-ABL1 kinase domain-mediated resistance in chronic myeloid leukemia.
Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis, 2014 Patients with chronic myeloid leukemia develop resistance to both first-generation and second-generation tyrosine kinase inhibitors (TKIs) as a result of mutations in the kinase domain (KD) of BCR-ABL1.
S. Soverini +8 more
semanticscholar +1 more source
Geological Journal, EarlyView.Early zircon saturation and crystallisation occur in mafic (52–54 wt.% SiO2) lavas at Tengchong volcanic field. These early formed zircons with high δ18O (6.6‰–7.9‰) indicates mantle enrichment by subducted supracrustal materials. ABSTRACT Late Pleistocene (< 0.2 Ma) mafic and evolved volcanic rocks occur in northern Tengchong Volcanic Field, SE ...
Lizhu Wang, Haibo Zou
wiley +1 more source
Suppression of autophagy by BCR ABL
Frontiers in Bioscience, 2012 Imatinib and second generation BCR/ABL tyrosine kinase inhibitors (TKIs) serve now as standard therapies for patients with chronic myelogenous leukemia (CML); however, CML stem cells are intrinsically insensitive to the cell death-inducing effects of TKIs, allowing the persistence of a "reservoir" of BCR/ABL-expressing CML-initiating cells potentially ...
CALABRETTA, Bruno, SALOMONI, Paolo
openaire +4 more sources
iLABMED, EarlyView.This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han +6 more
wiley +1 more source
Typical Chronic Myelogenous Leukemia With e19a2 Junction BCR/ABL Transcript [PDF]
, 1997 Montserrat Briz +4 more
openalex +1 more source
iNew Medicine, EarlyView.ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu +5 more
wiley +1 more source
Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains [PDF]
, 2013 Fern Sha +6 more
openalex +1 more source
Epigenetic Rewiring of BCR Signaling as a Novel Mechanism of Ibrutinib Resistance in ABC-DLBCL [PDF]
, 2021 Laura Pasqualucci
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Learning in radiation oncology: 12‐month experience with a new incident learning system
Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 63-73, March 2025.Introduction of an incident learning incident (ILS) was shown to have had a positive impact on reporting and safety culture within a local health district (LHD). Survey findings correlate with existing literature that ILSs are effective tools for improving patient safety and departmental safety facilitating quality improvement.
Krystle Crouch +4 more
wiley +1 more source
Haematologica, 2018 Accurate quantification of minimal residual disease (MRD) during treatment of chronic myeloid leukemia (CML) guides clinical decisions. The conventional MRD method, RQ-PCR for BCR-ABL1 mRNA, reflects a composite of the number of circulating leukemic ...
Ilaria S. Pagani +11 more
doaj +1 more source