Results 81 to 90 of about 109,902 (263)

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Learning in radiation oncology: 12‐month experience with a new incident learning system

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 63-73, March 2025.
Introduction of an incident learning incident (ILS) was shown to have had a positive impact on reporting and safety culture within a local health district (LHD). Survey findings correlate with existing literature that ILSs are effective tools for improving patient safety and departmental safety facilitating quality improvement.
Krystle Crouch, Laura Adamson, Rachael Beldham‐Collins, Jonathan Sykes, David Thwaites   +4 more
wiley   +1 more source

Farming in the shadows of Rome: A multi‐proxy palaeoenvironmental record from Loch Clunie—Perthshire

Journal of Quaternary Science, EarlyView.
ABSTRACT Roman impacts on local society is a subject of international significance. Loch Clunie, Perthshire, lies only 5.4 km from Inchtuthil, the only Roman legionary fortress in Scotland, and contains two crannogs and a probable lakeside hillfort. Despite this proximity and the likelihood of local–Roman interaction, these sites remain unexcavated ...
Samantha E. Jones, Maarten Blaauw, Fraser Hunter, Olalla López‐Costas, Antonio Martínez Cortizas, Tim M. Mighall, Gordon Noble   +6 more
wiley   +1 more source

Inhibition of autoantigen-induced B-cell receptor (BCR) internalization as a therapeutic strategy in diffuse large B cell lymphoma (DLBCL)

Cell Death and Disease
BCR signal dependency is a hallmark of diffuse large B-cell lymphoma (DLBCL) and other B-cell lymphoid malignancies originating from germinal centers. Chronic-active BCR signaling, typical for the more aggressive activated B-cell subtype (ABC) of DLBCLs,
Patryk Górniak, Anna Polak, Anna Rams, Kristyna Kupcova, Eliza Głodkowska-Mrówka, Zofia Pilch, Marta Miączyńska, Dominika Nowis, Jakub Gołąb, R. Eric Davis, Ondrej Havranek, Przemysław Juszczyński   +11 more
doaj   +1 more source

Immunocytochemical study of Bcr and Bcr-Abl localization in K562 cells.

Experimental oncology, 2010
To obtain polyclonal antibodies against recombinant proteins recognizing Bcr domain and fusion region of Bcr-Abl and analyze the patterns of intracellular distribution of Bcr and Bcr-Abl proteins in K562 cells of chronic myelogenous leukemia.The coding sequences of DH and PH domains of Bcr-Abl were cloned, and the recombinant proteins were expressed in
Telegeev, G.D., Dubrovska, A.N., Nadgorna, V.A., Dybkov, M.V., Zavelevich, M.P., Maliuta, S.S., Gluzman, D.F.   +6 more
openaire   +2 more sources

Copaiba oleoresin as a substitute for sodium lasalocid in high‐concentrate diets for lambs: growth performance, ingestive behavior, and metabolic and ruminal parameters

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The indiscriminate and excessive use of ionophore additives has been associated with the emergence of multi‐resistant pathogenic strains and the global spread of antibiotic resistance, raising serious public health concerns. Thus, plant biocompounds have been the focus of several studies aiming to replace ionophore additives in ...
Jéssica Carvalho de Pantoja, Aylpy Renan Dutra Santos, Cristiane Rebouças Barbosa, Carla Giselly Souza, Tatiane Fernandes, Elaine Cristina Pacheco de Oliveira, Marcio Rodrigues de Souza, Fernando Miranda de Vargas Junior   +7 more
wiley   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Moss Biocrusts Regulate Heavy Metal Speciation and Mobility in Coal Mine Soils

Land Degradation &Development, EarlyView.
ABSTRACT On a global scale, coal mining activities often lead to heavy metal(loid) contamination in soils of mine dump sites, posing serious ecological risks. As ecosystem “engineers,” biological soil crusts (biocrusts)—especially moss crust—have shown great potential in remediating heavy metal‐polluted soils, but their roles remain underexplored.
Song Guang, Yang Haotian, Wang Xinyu, Li Guoxin, Zheng Ying   +4 more
wiley   +1 more source

The molecular signature of BCR::ABLP210 and BCR::ABLT315I in a Drosophila melanogaster chronic myeloid leukemia model

iScience
Summary: Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder resulting from a balanced translocation leading to BCR::ABL1 oncogene with increased tyrosine kinase activity.
Amro Baassiri, Ali Ghais, Abdallah Kurdi, Elias Rahal, Rihab Nasr, Margret Shirinian   +5 more
doaj   +1 more source

Evaluation of Morpholino Antisense Oligos’ Role on BCR-ABL Gene Silencing in the K562 Cell Line [PDF]

Cell Journal, 2010
Objective: Chronic myeloid leukemia (CML) develops when a hematopoietic stem cellacquires the BCR/ABL fusion gene. This causes these transformed hematopoietic cellsto have a greater than normal proliferation rate.
Bahman Delalat, Soraya Rasi Ghaemi, Saeid Abroun, Mehrdad Noruzinia, Mahmoud Haririan, Masoud Soleimani, Saeid Kaviani   +6 more
doaj