Results 81 to 90 of about 179,498 (360)

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen, Mathilde Rønne Koch, Cecilie Utke Rank, Christen Lykkegaard Andersen, Allan Weimann, Maria Thastrup, Tianwu Yang, Trine Meldgaard Lund, Ib Jarle Christensen, Flemming Nielsen, Tore Bjerregaard Stage, Sara Bisgaard Jensen, Mette Klarskov Andersen, Kjeld Schmiegelow, Kim Dalhoff   +14 more
wiley   +1 more source

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, EarlyView.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Cardiovascular toxicity induced by TKIs in patients with chronic myeloid leukaemia: Are women and men different?

ESC Heart Failure, Volume 12, Issue 2, Page 1447-1454, April 2025.
This study analyzes 148 patients (66 women and 82 men) with chronic myeloid leukemia treated with tyrosine kinase inhibitors, focusing on cardiovascular adverse events. The risk assessment, performed using the HFA/ICOS score, reveals sex‐specific differences: venous thrombosis is more common in women, while arterial thrombosis predominates in men.
Cristina Madaudo, Daniela Di Lisi, Antonio Cannatà, Federica Manfrè, Celeste Vullo, Marco Santoro, Ciro Botta, Salvatrice Mancuso, Sergio Siragusa, Alfredo Ruggero Galassi, Giuseppina Novo   +10 more
wiley   +1 more source

Box-Behnken Design-Based Optimization and Evaluation of Lipid-Based Nano Drug Delivery System for Brain Targeting of Bromocriptine

Pharmaceuticals
Bromocriptine (BCR) presents poor bioavailability when administered orally because of its low solubility and prolonged first-pass metabolism. This poses a significant challenge in its utilization as an effective treatment for managing Parkinson’s disease
Asha Spandana K M, Mohit Angolkar, Mohamed Rahamathulla, Kamal Y. Thajudeen, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana, Thippeswamy Boreddy Shivanandappa, Sharanya Paramshetti, Riyaz Ali M. Osmani, Jawahar Natarajan   +9 more
doaj   +1 more source

Evidence From Microscopy and U–Pb Geochronology as a Clue to the Influence of the Cretaceous Magmatism in the Diagenesis of Pre‐Salt Carbonate Reservoirs in the Santos Basin (Brazil)

Geological Journal, EarlyView.
Carbonates from Santos Basin revealed U–Pb ages correlated with basalt ages (A), suggesting that they were formed during magmatic events. These events placed hot CO2 in the reservoir, which, when mixed with carbonate‐rich cold water (B), led to thermal convection, enabling the formation of the U contained in the carbonates.
Marco António Ruivo de Castro e Brito, Cristiano Leite Sombra, Davy Raeder Brandão, Cleverson Guizan Silva, Sidney Luiz de Matos Mello, Eugênio Vaz dos Santos Neto, Rui Jorge Fernandes Baptista, Ramsés Capilla, Luiz Antônio Pierantoni Gambôa   +8 more
wiley   +1 more source

The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold

eLife, 2015
B lymphocytes use B cell receptors (BCRs) to sense the physical features of the antigens. However, the sensitivity and threshold for the activation of BCRs resulting from the stimulation by mechanical forces are unknown.
Zhengpeng Wan, Xiangjun Chen, Haodong Chen, Qinghua Ji, Yingjia Chen, Jing Wang, Yiyun Cao, Fei Wang, J. Lou, Zhuo Tang, Wanli Liu   +10 more
semanticscholar   +1 more source

Replacement of Ores Recorded by Textures and Chemical Compositions of Sphalerite: An Example From the Furutobe Kuroko Deposit, Akita, Japan

Geological Journal, EarlyView.
Coupled dissolution‐reprecipitation of early formed Cd‐, Fe‐, Ag‐ and Sb‐poor sphalerite through interaction with high‐temperature and high‐sulphur fugacity Cu‐rich fluids, responsible for the formation of the yellow ores, resulted in the formation of Cd‐, Fe‐, Ag‐ and Sb‐rich, heavily chalcopyrite‐diseased sphalerite and enrichment of critical metals ...
Manuel Nopeia, Ryohei Takahashi, Andrea Agangi, Pearlyn Manalo, Hinako Sato   +4 more
wiley   +1 more source

High-Level Expression, Purification and Characterization of A Recombinant Plasmodium vivax Apical Membrane Antigen 1: Implication for vivax Malaria Vaccine Development

Cell Journal, 2015
Objective: The apical membrane antigen-1 (AMA-1) is considered as a promising candidate for development of a malaria vaccine against Plasmodium parasites.
Maryam Salavatifar, Sedigheh Zakeri, Nasim Hayati Roodbari, Navid Dinparast Djadid   +3 more
doaj  

Geochemistry and Geochronology of Magmatic Rocks in Southwestern and Northeastern Cambodia: Implications for the Tectonic Evolution and Metallogenesis of the Loei Fold Belt

Geological Journal, EarlyView.
The composition of intrusive rocks suggests that the magma was likely generated in a subduction‐related setting. The arc crustal thickness in the Phnom Sro Ngam and Halo Prospects was probably < 40 km during emplacement. Zircon U–Pb age range indicates a correlation with Loei Fold Belt magmatic activity.
Sirisokha Seang, Khin Zaw, Kakda Kret, Ivan Belousov, Kotaro Yonezu, Koichiro Watanabe, Charles Makoundi   +6 more
wiley   +1 more source