Results 291 to 300 of about 179,498 (360)

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.

Journal of Medicinal Chemistry, 2018
Chronic myelogenous leukemia (CML) arises from the constitutive activity of the BCR-ABL1 oncoprotein. Tyrosine kinase inhibitors (TKIs) that target the ATP-binding site have transformed CML into a chronic manageable disease.
J. Schoepfer, W. Jahnke, Giuliano Berellini, S. Buonamici, S. Cotesta, S. Cowan-Jacob, S. Dodd, P. Drueckes, D. Fabbro, Tobias Gabriel, Jean-Marc Groell, R. Grotzfeld, A. Q. Hassan, Chrystèle Henry, Varsha Iyer, Darryl Jones, F. Lombardo, Alice T. Loo, P. Manley, X. Pelle, G. Rummel, Bahaâ Salem, M. Warmuth, A. Wylie, T. Zoller, A. Marzinzik, P. Furet   +26 more
semanticscholar   +1 more source

CRKL Binding to BCR-ABL and BCR-ABL Transformation

Leukemia & Lymphoma, 1999
The SH2-SH3 domain-containing adaptor protein CRKL is the predominant tyrosine phosphorylated protein in chronic myelogenous leukemia (CML) neutrophils and BCR-ABL-expressing cell lines. The amino terminal CRKL SH3 domain binds directly to a proline-rich region in the C-terminus of BCR-ABL. BCR-ABL mutants with deletions of this region were constructed
K S, Kolibaba, A, Bhat, C, Heaney, T, Oda, B J, Druker   +4 more
openaire   +2 more sources

Discovery of SIAIS178 as an effective BCR-ABL degrader by recruiting von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.

Journal of Medicinal Chemistry, 2019
The oncogenic fusion protein BCR-ABL is the driving force of leukemogenesis in chronic myeloid leukemia (CML). Despite great progress for CML treatment through application of tyrosine kinase inhibitors (TKIs) against BCR-ABL, long-term drug ...
Quanju Zhao, Chaowei Ren, Linyi Liu, Jinju Chen, Yubao Shao, Ning Sun, Renhong Sun, Ying Kong, Xinyu Ding, Xianfang Zhang, Youwei Xu, Bei Yang, Qianqian Yin, Xiaobao Yang, B. Jiang   +14 more
semanticscholar   +1 more source

Biology of BCR-ABL

Blood Reviews, 1999
gene on chromosome 9 is the humanhomologue of a gene originally identified in a murineoncogenic virus, the Abelson murine leukaemia virus(A-MuLV). This retrovirus was isolated from a pred-nisolone treated mouse which developed lymphomafollowing innoculation with Moloney murineleukaemia virus (M-MuLV).
R, Chopra, Q Q, Pu, A G, Elefanty
openaire   +2 more sources

BCR/ABL and leukemia

Leukemia Research, 1996
This review focuses on the role of the chimeric BCR/ABL gene in leukemia development. First, we discuss and update knowledge regarding the molecular biology of BCR/ABL. We then review data regarding transforming activity of BCR/ABL. Third, we discuss the complex interactions between BCR/ABL and leukemia phenotype. We conclude with a brief discussion of
A, Butturini, R B, Arlinghaus, R P, Gale
openaire   +2 more sources

???????????? ?????????????????? ?? ?????????????????? ?????????????????? ???? ???????????? ?????????? Bcr

2008
The primary structure of Bcr PH domain is analyzed by using biological databank. To obtain the experimental secondary structure content of the recombinant PH protein, CD spectra were measured at 200???240 nm. The data observed correlate to ones for PH domains with determined structure.
openaire   +3 more sources

Internalization of BCR in EU12 µHC+ cells by BCR-Crosslinking cells by BCR-Crosslinking (132.27)

The Journal of Immunology, 2010
Abstract Engagement of the B cell antigen receptor (BCR) on mature B cells activates signal transduction pathways leading to B cell activation. It has also been shown that crosslinking BCR on murine mature B cells results in partial BCR internalization and limited receptor recycling.
Kathleen Marran-Nichol, Jing Lui, Zhixin Zhang   +2 more
openaire   +1 more source

Regulation of BCR signaling

Molecular Immunology, 2011
B cells and antibodies are important elements of acquired humoral immunity in the fight against various pathogens, and signals through the B cell receptor (BCR) are crucial for the development, activation and differentiation of B cells. Our laboratory has focused on understanding the molecular mechanisms of BCR-mediated signaling cascades that regulate
openaire   +3 more sources

???????????????? ???????????? DH/PH ?????????????? ?????????? Bcr ???? ?????????????????????? ?????????????????????? ???????????????????????? Bcr-Abl

2021
?????????????? ?????????????? DH, PH ?????????????? Bcr ?????????? ???? ?????????????????????? Bcr-Abl ?? ????????????. ??????????????????????, ?????? ?????????????? PH ???????????? ???????????????????? ?????????????????????????????? ?????????????????????? ?????????? ??????????, ?????????????????????????? ?????? ???????????????????????????? ?? ?????????
openaire   +1 more source

???????????????? bcr ?????????????? ???????????????????? ???????? bcr-abl ???? ???????? ???? ?????????????????? ???????????????????? ???????????????? ?????? ???????????????????????? (9:22)

2021
Bcr ???????????????? ?????????????????? ???????????? ???????????????????? ???????? bcr-abl, ?????????????????????????? ?????? ?????????????????? t(9;22). ???????????? ???? ???????????????? ???????????????????????? ???????????????? ???????????????????????? ?????????????? ?? ???????????????? ??????????????????????. ?? ???????????? ?? ?????????????? ??????
openaire   +1 more source