Results 211 to 220 of about 97,924 (263)

Lactational Serotonergic Perturbation Imprints Stress-Related Transcriptional Profiles in the Adolescent Female Rat Prefrontal Cortex. [PDF]

ACS Chem Neurosci
Gallo MT, Acquah AME, Sbabo L, Fumagalli F, Brivio P, Calabrese F.   +5 more
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To BDNF or Not to BDNF: That Is the Epileptic Hippocampus

The Neuroscientist, 2005
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has drawn much attention as a potential therapeutic target for temporal lobe epilepsy (TLE). TLE seizures are produced by synchronized hyperactivity of neuron populations due to the disruption of a balance between excitatory and inhibitory synaptic transmissions.
Ryuta, Koyama, Yuji, Ikegaya
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NGF and BDNF in pediatrics syndromes

Neuroscience & Biobehavioral Reviews, 2023
Neurotrophins (NTs) as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) play multiple roles in different settings including neuronal development, function and survival in both the peripheral and the central nervous systems from early stages.
Ferraguti, Giampiero, Terracina, Sergio, Micangeli, Ginevra, Lucarelli, Marco, Tarani, Luigi, Ceccanti, Mauro, Spaziani, Matteo, D'Orazi, Valerio, Petrella, Carla, Fiore, Marco   +9 more
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Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

Nature Neuroscience, 2008
Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by ...
Matsumoto, T., Rauskolb, S., Polack, M., Klose, J., Kolbeck, R., Korte, M., Barde, Y. -A.   +6 more
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Steroid hormones and BDNF

Neuroscience, 2013
Brain-derived neurotrophic factor (BDNF) is a neurotrophin abundantly expressed in several areas of the central nervous system (CNS) and is known to induce a lasting potentiation of synaptic efficacy, to enhance specific learning and memory processes.
Pluchino N, Russo M, Santoro AN, LITTA, PIETRO SALVATORE, Cela V, Genazzani AR   +5 more
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Association of circulating BDNF levels with BDNF rs6265 polymorphism in schizophrenia

Behavioural Brain Research, 2020
Schizophrenia is a severe neuropsychiatric disorder affecting 1% of the world population. Disturbances in neuronal development and synaptic connections are important factors in the pathogenesis of schizophrenia. Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays a critical role in the development of neurons.
Pvsn Kiran, Kumar, Prasenjit, Mitra, Raghumoy, Ghosh, Shailja, Sharma, Naresh, Nebhinani, Praveen, Sharma   +5 more
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BDNF dependence in neuroblastoma

Journal of Neuroscience Research, 2001
AbstractNeuroblastomas are heterogeneous tumors arising from sympathetic precursors in the neural crest. Growth factor stimulation of neuroblastomas promote diverse biological responses (mitogenesis, differentiation, cell death) depending on the particular tumor studied.
X, Feng, H, Jiang, J C, Baik, C, Edgar, F F, Eide   +4 more
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A role for BDNF in mechanosensation

Nature Neuroscience, 1998
Brain-derived neurotrophic factor (BDNF) is a survival factor for certain sensory neurons during development. Using electrophysiology in BDNF-deficient mice, we show here that slowly adapting mechanoreceptors (SAM), but not other types of cutaneous afferents, require BDNF in postnatal life for normal mechanotransduction.
P, Carroll, G R, Lewin, M, Koltzenburg, K V, Toyka, H, Thoenen   +4 more
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BDNF During Withdrawal

2017
Among the adaptations observed following drugs of abuse consumption, BDNF levels are widely altered in both brain and periphery. In this chapter, we first reviewed these adaptations in preclinical studies, in both juveniles and adult animals. A particular focus was made on protracted withdrawal as incubation is often associated with an increase in ...
H, Geoffroy, F, Noble
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BDNF as a pain modulator

Progress in Neurobiology, 2008
At least some neurotrophins may be powerful modulators of synapses, thereby influencing short- and long-term synaptic efficiency. BDNF acts at central synapses in pain pathways both at spinal and supraspinal levels. Neuronal synthesis, subcellular storage/co-storage and release of BDNF at these synapses have been characterized on anatomical and ...
A. Merighi, C. Salio, GHIRRI, Alessia, L. Lossi, F. Ferrini, BETELLI, CHIARA, BARDONI, Rita   +6 more
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