Results 41 to 50 of about 18,075 (260)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

LEO ISL-Assisted BDS-3 and LEO Rapid Joint Precise Orbit Determination

Remote Sensing
BDS-3 faces challenges in achieving precision orbit determination (POD) due to the difficulty of establishing a globally uniform distribution of independently operated ground tracking stations. The use of onboard BDS-3 observations collected by low Earth
Le Wang, Dandan Song, Wen Lai, Bobin Cui, Guanwen Huang   +4 more
doaj   +1 more source

Performance Assessment of BDS-2/BDS-3/GPS/Galileo Attitude Determination Based on the Single-Differenced Model with Common-Clock Receivers

Remote Sensing, 2021
Global navigation satellite system (GNSS)-based attitude determination has been widely applied in a variety of fields due to its high precision, no error accumulation, low power consumption, and low cost. Recently, the emergence of common-clock receivers
Mingkui Wu, Shuai Luo, Wang Wang, Wanke Liu   +3 more
doaj   +1 more source

Aufsätze. Bd. 3: 2015 - 2022

, 2022
Vorwort zur 2. Auflage: In der zweiten Auflage habe ich den Aufsatz „Gottesbeweise – was man alles akzeptieren muss, um sie plausibel finden zu können“ hinzugefügt. Einige andere Beiträge wurden leicht überarbeitet.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Comprehensive Signal Quality Assessment for BDS/Galileo/GPS Satellites and Signals

Remote Sensing
With the modernization of global navigation satellite systems (GNSS), especially the rapid development of the BeiDou Navigation Satellite System (BDS), more observations of satellites and signals have become available.
Yijun Tian, Guorui Xiao, Rui Guo, Dongqing Zhao, Lu Zhang, Jie Xin, Jinglei Guo, Yuechao Han, Xuefan Du, Donghan He, Zheng Qin   +10 more
doaj   +1 more source

Studies and Analysis of Combining BDS-3/GNSS Ultra-Rapid Orbit Products from Different IGS Analysis Centers

Remote Sensing, 2022
The third generation of China’s BeiDou Navigation Satellite System (BDS-3) began to provide global service at the end of 2018, and the completion of BDS was announced in July 2020, which includes GEO (Geostationary Earth Orbit), IGSO (Inclined ...
Yangfei Hou, Hu Wang, Jiexian Wang, Hongyang Ma, Yingying Ren, Pengyuan Li, Yafeng Wang   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Competition Pattern and Coping Strategies in Near Space [PDF]

中国工程科学
The near space serves as a transition area between airspace and the outer space, and it has unique strategic values and broad application prospects, attracting countries to compete for development.
Junlin Yang, Jingfan Yang, Dongxu Liu, WenQing Zhang, Lijing Li   +4 more
doaj   +1 more source