Results 51 to 60 of about 18,991 (299)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

High-Accuracy Clock Offsets Estimation Strategy of BDS-3 Using Multi-Source Observations

Remote Sensing, 2022
Satellite clock offsets are the critical parameters for The Global Navigation Satellite Systems (GNSSs) to provide position and timing (PNT) service. Unlike other GNSSs, BDS-3 uses the two-way superimposition strategy to measure satellite clock offsets ...
Jianhua Yang, Chengpan Tang, Sanshi Zhou, Yezhi Song, Jinhuo Liu, Yu Xiang, Yuchen Liu, Qiuning Tian, Yufei Yang, Zuo Yang, Xiaogong Hu   +10 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LEO ISL-Assisted BDS-3 and LEO Rapid Joint Precise Orbit Determination

Remote Sensing
BDS-3 faces challenges in achieving precision orbit determination (POD) due to the difficulty of establishing a globally uniform distribution of independently operated ground tracking stations. The use of onboard BDS-3 observations collected by low Earth
Le Wang, Dandan Song, Wen Lai, Bobin Cui, Guanwen Huang   +4 more
doaj   +1 more source

Performance Assessment of BDS-2/BDS-3/GPS/Galileo Attitude Determination Based on the Single-Differenced Model with Common-Clock Receivers

Remote Sensing, 2021
Global navigation satellite system (GNSS)-based attitude determination has been widely applied in a variety of fields due to its high precision, no error accumulation, low power consumption, and low cost. Recently, the emergence of common-clock receivers
Mingkui Wu, Shuai Luo, Wang Wang, Wanke Liu   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Comprehensive Signal Quality Assessment for BDS/Galileo/GPS Satellites and Signals

Remote Sensing
With the modernization of global navigation satellite systems (GNSS), especially the rapid development of the BeiDou Navigation Satellite System (BDS), more observations of satellites and signals have become available.
Yijun Tian, Guorui Xiao, Rui Guo, Dongqing Zhao, Lu Zhang, Jie Xin, Jinglei Guo, Yuechao Han, Xuefan Du, Donghan He, Zheng Qin   +10 more
doaj   +1 more source