Results 51 to 60 of about 19,364 (340)

Respons Verbal Anak Usia 5—6 Tahun pada Tindak Tutur Direktif Orang Tua [PDF]

, 2018
Penelitian ini bertujuan untuk menjelaskan bentuk tindak tutur direktif dan strategi bertutur yang digunakan oleh orang tua, serta respons verbal anak usia 5—6 tahun pada tindak tutur orang tua mereka.
Wulandari, S. (Sovia)
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Long-Term Performance Evaluation of BeiDou PPP-B2b Products and Its Application in Time Service

Remote Sensing, 2023
Precise Point Positioning (PPP) is an official service of the BeiDou Global Navigation Satellite System (BDS-3) through the PPP-B2b signal. In this paper, we mainly focus on the long-term performance evaluation of BDS-3 PPP-B2b products and their ...
Qianqian He, Liang Chen, Lei Liu, Daiyan Zhao, Xiaopeng Gong, Yidong Lou, Qi Guan   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

High-Accuracy Clock Offsets Estimation Strategy of BDS-3 Using Multi-Source Observations

Remote Sensing, 2022
Satellite clock offsets are the critical parameters for The Global Navigation Satellite Systems (GNSSs) to provide position and timing (PNT) service. Unlike other GNSSs, BDS-3 uses the two-way superimposition strategy to measure satellite clock offsets ...
Jianhua Yang, Chengpan Tang, Sanshi Zhou, Yezhi Song, Jinhuo Liu, Yu Xiang, Yuchen Liu, Qiuning Tian, Yufei Yang, Zuo Yang, Xiaogong Hu   +10 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Assessment of pap smear and colposcopic findings in patients with vaginal discharge [PDF]

New Indian Journal of OBGYN, 2019
Aim: Present study was performed with an aim to see the types of vaginal discharge with the pap smear and colposcopic findings. Material and Methods: This cross-sectional study was conducted in 68 women attending outpatient department (OPD) of Obstetrics
Nagajan Bhadarka, Nimish Pandya, Satyam Joshi   +2 more
doaj   +1 more source

BeiDou-3 orbit and clock quality of the IGS Multi-GNSS Pilot Project

, 2022
Within the Multi-GNSS Pilot Project (MGEX) of the International GNSS Service (IGS), precise orbit and clock products for the BeiDou-3 global navigation satellite system (BDS-3) are routinely generated by a total of five analysis centers.
Deng, Zhiguo, Guo, Jing, Montenbruck, Oliver, Prange, Lars, Song, Shuli, Steigenberger, Peter   +5 more
core   +1 more source