Results 61 to 70 of about 19,364 (340)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

LEO ISL-Assisted BDS-3 and LEO Rapid Joint Precise Orbit Determination

Remote Sensing
BDS-3 faces challenges in achieving precision orbit determination (POD) due to the difficulty of establishing a globally uniform distribution of independently operated ground tracking stations. The use of onboard BDS-3 observations collected by low Earth
Le Wang, Dandan Song, Wen Lai, Bobin Cui, Guanwen Huang   +4 more
doaj   +1 more source

The T Tauri Phase Down to Nearly Planetary Masses: Echelle Spectra of 82 Very Low Mass Stars and Brown Dwarfs

, 2005
Using the largest high-resolution spectroscopic sample to date of young, very low mass stars (VLMS) and brown dwarfs (BDs), we investigate disk accretion in objects ranging from just above the hydrogen-burning limit all the way to nearly planetary masses.
Baraffe I., Bouvier J., Comeron F., D’Antona F., Gibor Basri, Martin E., Monin J.-L., Preibisch T., Ray Jayawardhana, Subhanjoy Mohanty   +9 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A Comprehensive Signal Quality Assessment for BDS/Galileo/GPS Satellites and Signals

Remote Sensing
With the modernization of global navigation satellite systems (GNSS), especially the rapid development of the BeiDou Navigation Satellite System (BDS), more observations of satellites and signals have become available.
Yijun Tian, Guorui Xiao, Rui Guo, Dongqing Zhao, Lu Zhang, Jie Xin, Jinglei Guo, Yuechao Han, Xuefan Du, Donghan He, Zheng Qin   +10 more
doaj   +1 more source

Real-time marine PPP-B2b/SINS integrated navigation based on BDS-3 [PDF]

, 2023
Ming Li, Hongzhou Chai
openalex   +1 more source

Atypical “seizure-like” activity in cortical reverberating networks in vitro can be caused by LPS-induced inflammation: a multi-electrode array study from a hundred neurons [PDF]

, 2014
We show here that a mild sterile inflammation induced by the endotoxin lipopolysaccharide (LPS), in a neuron/astrocyte/microglial cortical network, modulates neuronal excitability and can initiate long-duration burst events resembling epileptiform ...
Alida Amadeo, Andrew Constanti, Barbara Costa, Enzo Wanke, Francesca Gullo, Giulia Donvito, Marzia Lecchi   +6 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Studies and Analysis of Combining BDS-3/GNSS Ultra-Rapid Orbit Products from Different IGS Analysis Centers

Remote Sensing, 2022
The third generation of China’s BeiDou Navigation Satellite System (BDS-3) began to provide global service at the end of 2018, and the completion of BDS was announced in July 2020, which includes GEO (Geostationary Earth Orbit), IGSO (Inclined ...
Yangfei Hou, Hu Wang, Jiexian Wang, Hongyang Ma, Yingying Ren, Pengyuan Li, Yafeng Wang   +6 more
doaj   +1 more source

Assessment of Real-Time GPS/BDS-2/BDS-3 Single-Frequency PPP and INS Tight Integration Using Different RTS Products [PDF]

, 2022
Jie Lv, Zhouzheng Gao, Qiaozhuang Xu, Ruohua Lan, Cheng Yang, Junhuan Peng   +5 more
openalex   +1 more source