Results 81 to 90 of about 18,991 (299)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Undifferenced and Uncombined GNSS Time Transfer and its Space Applications [PDF]

, 2023
This thesis presents a framework for developing a state-of-the-art undifferenced and uncombined (UDUC) time transfer technique for space applications.
Mi, Xiaolong
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Chemical tracers in proto-brown dwarfs: CO, ortho-H$_{2}$CO, para-H$_{2}$CO, HCO$^{+}$, CS observations

, 2018
We present a study of the CO isotopologues and the high-density tracers H$_{2}$CO, HCO$^{+}$, and CS in Class 0/I proto-brown dwarfs (proto-BDs). We have used the IRAM 30m telescope to observe the $^{12}$CO (2-1), $^{13}$CO (2-1), C$^{18}$O (2-1), C$^{17}
Caselli, P., Riaz, B., Thi, W. F.
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Improving the performance of BDS single-frequency precise point positioning by integrating QZSS observations in the Asia-Pacific region

Earth, Planets and Space
Japan’s Quasi-Zenith Satellite System (QZSS) as an important supplement to the Global Navigation Satellite System (GNSS) can provide great positioning, navigation and timing (PNT) services in the Asia-Pacific region.
Ahao Wang, Yunzhao Li, Haowei Zhang, Runqi Tian, Shangshang Wan   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Kinematic Absolute Positioning with Quad-Constellation GNSS [PDF]

, 2019
The absolute positioning technique is based on a point positioning mode with a single Global Navigation Satellite System (GNSS) receiver, which has been widely used in many fields such as vehicle navigation and kinematic surveying.
Cai, Changsheng, Cui, Xianqiang, Pan, Lin, Zhu, Jianjun   +3 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Optimizing PPP-AR with BDS-3 and GPS: Positioning Performance Across Diverse Geographical Regions Under Mostly Quiet Space Weather Conditions

Atmosphere
The integration of Global Navigation Satellite Systems (GNSS) has revolutionized geodetic positioning, with techniques like Precise Point Positioning with Ambiguity Resolution (PPP-AR) offering highly accurate results with reduced convergence times.
Burhaneddin Bilgen
doaj   +1 more source