Results 81 to 90 of about 17,645 (277)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
BP-LMS-based BDS-3 power system positioning method
, 2022 Ruifeng Zhao +4 more
openalex +1 more source
Decimeter-level algorithm for satellite-based augmentation systems and performance analysis of BDS-2/BDS-3 [PDF]
, 2020 Jianhua Zhou +5 more
openalex +1 more source
A novel fine Doppler frequency acquisition algorithm for BDS‐3 B1C signal based on an adaptive filter [PDF]
, 2021 Tongsheng Qiu +4 more
openalex +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
Characterization of GNSS Signals Tracked by the iGMAS Network Considering Recent BDS-3 Satellites
Remote Sensing, 2018 The international GNSS monitoring and assessment system (iGMAS) tracking network has been established by China to track multi-GNSS satellites. A key feature of iGMAS stations is the capability to fully track new navigation signals from the recently ...
Xin Xie +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Remote Sensing, 2019 The accuracy of ultra-rapid orbits is a key parameter for the performance of GNSS (Global Navigation Satellite System) real-time or near real-time precise positioning applications.
Qianxin Wang, Chao Hu, Kefei Zhang
doaj +1 more source