Results 101 to 110 of about 115,902 (249)

Binary Stars Take What They Get: Evidence for Efficient Mass Transfer from Stripped Stars with Rapidly Rotating Companions

The Astrophysical Journal Letters
Binary stars and their interactions shape the formation of compact binaries, supernovae, and gravitational-wave sources. The efficiency of mass transfer—the fraction of mass retained by the accretor during binary interaction—is a critical parameter that ...
Thibault Lechien, Selma E. de Mink, Ruggero Valli, Amanda C. Rubio, Lieke A. C. van Son, Robert Klement, Harim Jin, Onno Pols   +7 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Triple System V1371 Tau: An Eclipsing Binary with an Outer Be Star

The Astrophysical Journal
Although triple systems are common, their orbital dynamics and stellar evolution remain poorly understood. We investigated the V1371 Tau system using TESS photometry, multiepoch spectroscopy, and recent interferometric data, confirming it as a rare ...
Danilo F. Rocha, Marcelo Emilio, Jonathan Labadie-Bartz, Coralie Neiner, Julia Bodensteiner, Tomer Shenar, Laerte Andrade, Michael Abdul-Masih, Felipe Navarete, Alessandro Melo, Eduardo Janot-Pacheco, Romualdo Eleutério, Alan W. Pereira   +12 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

To Be or Not To Be: The Role of Rotation in Modeling Galactic Be X-Ray Binaries

The Astrophysical Journal
Be X-ray binaries (Be-XRBs) are one of the largest subclasses of high-mass X-ray binaries, comprised of a rapidly rotating Be star and neutron star companion in an eccentric orbit, intermittently accreting material from a decretion disk around the donor.
Kyle Akira Rocha, Vicky Kalogera, Zoheyr Doctor, Jeff J. Andrews, Meng Sun, Seth Gossage, Simone S. Bavera, Tassos Fragos, Konstantinos Kovlakas, Matthias U. Kruckow, Devina Misra, Philipp M. Srivastava, Zepei Xing, Emmanouil Zapartas   +13 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source