Results 251 to 260 of about 517,512 (310)

Toxicity of methyl testosterone in the beagle dog

Toxicology, 1977
When methyl testosterone was administered orally to beagle dogs at dosage levels of 2, 4 and 6 mg/kg per day for 27 weeks, hepatotoxicity was induced. The change induced was characterized by enlargement of periportal hepatocytes and the presence of haemosiderin within macrophages. There was some evidence of recovery over a 13-week period.
R, Heywood, H, Chesterman, S A, Ball, P F, Wadsworth   +3 more
openaire   +2 more sources

The effects of physostigmine on the electroretinogram in the beagle dog

Veterinary Research Communications, 1995
The purpose of the study was to correlate electroretinogram (ERG) parameters with increasing levels of plasma, erythrocyte and ocular tissue cholinesterase inhibition using the beagle dog as a model for human neurovisual toxicity. The anticholinesterase compound physostigmine was administered at various steady-state intravenous infusion rates based on ...
R D, Jones, B F, Hamilton, P D, Dass
openaire   +2 more sources

Frequency of CYP1A2 Polymorphism in Beagle Dogs

Drug Metabolism Letters, 2007
A single nucleotide polymorphism in the dog CYP1A2 gene causes these animals to be CYP1A2 deficient (i.e., lack functional CYP1A2 enzyme activity). Genotyping a colony of 79 dogs revealed 77% wild-type, 19% heterozygous, and 4% homozygous mutant animals. These genetic frequencies are significantly different from those previously reported and illustrate
Valerie J, Whiterock, Terrye A, Delmonte, Lester E, Hui, Tami L, Orcutt, Michael W, Sinz   +4 more
openaire   +2 more sources

THE CHROMOSOMES OF THE BEAGLE DOG

Journal of Heredity, 1963
W, MOORE, P D, LAMBERT
openaire   +2 more sources

Impaired spermatogenesis, tubular wall disruption, altered blood-testis barrier composition and intratubular lymphocytes in an infertile Beagle dog - a putative case of autoimmune orchitis.

Histology and Histopathology, 2019
Carolin Matschurat, Kristina Rode, Julia Hollenbach, K. Wolf, C. Urhausen, A. Beineke, A. Günzel-Apel, R. Brehm   +7 more
semanticscholar   +1 more source

RESPONSE AND ADAPTATION OF BEAGLE DOGS TO HYPERGRAVITY

1975
Eight male Beagle dogs, five months old, were centrifuged for three months at progressively increasing loads ranging from 1.5 g to 2.5 g on a 7.9 m radius centrifuge. Dogs were maintained on the centrifuge, which was run almost continuously, by employing a special designed automated waste disposal and life support system.
openaire   +2 more sources

MIRTAZAPINE IN BEAGLE DOGS

2011
Objective: Mirtazapine (MRT) is a human antidepressant drug mainly metabolized by the cytochrome P450 enzyme system to 8-OH mirtazapine (8-OH) and to dimetilmirtazapine (DMR). Anecdotal clinical observations suggested doses for dogs be extrapolated from human doses, but no pharmacological studies have been reported to date to support these speculations.
GIORGI, MARIO, V. Nikoui, A. Bakhtiarian, H. Yun   +3 more
openaire   +1 more source

A Novel Self-Expandable, Radioactive Airway Stent Loaded with 125I Seeds: A Feasibility and Safety Study in Healthy Beagle Dog

Cardiovascular and Interventional Radiology, 2017
Yong Wang, Jin-He Guo, Guang-Yu Zhu, Hai-Dong Zhu, Li Chen, Jian Lu, Chao Wang, G. Teng   +7 more
semanticscholar   +1 more source

A retinal dysplasia in the Beagle dog

Veterinary Record, 1970
R, Heywood, G A, Wells
openaire   +2 more sources

Ochratoxicosis in Beagle dogs.

Veterinary pathology, 1975
Abstract not ...
openaire   +1 more source