Results 91 to 100 of about 475,810 (306)

Ecological implications from spatial patterns in human-caused brown bear mortality

open access: yesWildlife Biology, 2016
Humans are important agents of wildlife mortality, and understanding such mortality is paramount for effective population management and conservation. However, the spatial mechanisms behind wildlife mortality are often assumed rather than tested, which ...
Sam Steyaert   +9 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Cleveland avenue bear promotion

open access: yes, 1954
Black and white photograph of the Big Bear exterior located at 3515 Cleveland Ave. Columbus, Ohio. Children enjoyed going to the store with their parents because a trained bear was caged near the entrance and did tricks for those who stopped to watch ...
Big Bear
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

1958 illuminated Big Bear billboard

open access: yes, 1958
Illuminated Big Bear billboard from 1958. The billboard reads, " Big Bear. Always convenient parking! Columbus most modern super markets." In 1934, an innovation in food retailing was introduced in Columbus when Wayne E.
Big Bear
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Bear at the Graceland Shopping Center Big Bear location

open access: yes, 1954
Graceland, Columbus, Ohio Wayne E. Brown at the Graceland Shopping Center Big Bear location. Big Bear is responsible for many innovations in the supermarket business. They were the first to introduce motorized counters that were controlled by the cashier.
Big Bear
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Bud Bowman at Big Bear

open access: yes, 1930
Bud Bowman and Big Bear standing outside the Buckeye Premium Stamp Redemption Center, Big Bear Store #1, Lane Avenue, Columbus, Ohio. The Lane Avenue store, which opened in 1934, was the first Big Bear store and the first self-service supermarket in ...
Big Bear
core  

Bearing Black [PDF]

open access: yesJournal for Social Action in Counseling & Psychology, 2013
In this essay I critically examine the idea of race in light of the killing of Trayvon Martin, an African-American unarmed teenager, in Florida in February 2012. I utilize ideas from liberation psychology, including psychic colonization, and depth psychology, including cultural complex, to explore the racialized black as a colonized, traumatized other.
openaire   +3 more sources

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