Results 101 to 110 of about 475,810 (306)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Zanesville Big Bear canned goods
, 1948 Canned goods at Zanesville Big Bear location, in June of 1948. Big Bear is responsible for many innovations in the supermarket business. They were the first to introduce motorized counters that were controlled by the cashier. Unique store layouts placing
Big Bear
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Zanesville Big Bear store interior
, 1948 Canned goods at Zanesville Big Bear location, in June of 1948. Big Bear is responsible for many innovations in the supermarket business. They were the first to introduce motorized counters that were controlled by the cashier. Unique store layouts placing
Big Bear
core
A new fractional derivative and its application to explanation of polar bear hairs
, 2016 A new fractional derivative is defined through the variational iteration method, and its application in explaining the excellent thermal protection of polar bear hairs is elucidated.
Ji-Huan He, Zheng-Biao Li, Qingli Wang
semanticscholar +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 1962 Black and white photograph of Big Bear Farms in Powell, Ohio. Big Bear Farms provided a good portion of the meats offered by the self service Big Bear chain stores.
Big Bear
core
Sensors, 2019 An optical cavity-based sensor using a differential detection method has been proposed for point-of-care diagnostics. We developed a low-cost and portable optical cavity-based sensor system using a 3D printer and off-the-shelf optical components. In this
Donggee Rho +2 more
doaj +1 more source
, 2016 Bhutan has 2 of the 8 species of bears recorded in the world: Asiatic black bear and Sloth bear. Asiatic black bear is listed in Appendix I of the CITES and categorized as vulnerable in IUCN Red List.
Yonten Jamtsho, S. Wangchuk
semanticscholar +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source