Results 51 to 60 of about 994,111 (289)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Chinese Journal of Mechanical Engineering, 2018 The spherical plain bearing test bench is a necessary detecting equipment in the research process of self-lubricating spherical plain bearings. The varying environmental temperatures cause the thermal deformation of the wear-depth detecting system of ...
Zhan-Qi Hu +4 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
LubricantsOscillating grease-lubricated slewing bearings are used in several applications. One of the most demanding and challenging is the rotor blade bearings of wind turbines. They allow the rotor blades to be turned to control the rotational speed and loads of
Arne Bartschat +2 more
doaj +1 more source
Validation of a finite-element model of a 5 m three-row roller wind turbine blade bearing [PDF]
Wind Energy ScienceLarge rolling bearings with complex interfaces need reliable finite-element (FE) models to determine the load distribution and deformation behavior. To ensure the accuracy of the results, it is important to validate the models against experimental data ...
M. Graßmann, M. Geibel, F. Schleich
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
MetalsNickel-, iron-, and cobalt-based alloy coatings were fabricated on the surface of U75V steel utilizing plasma cladding technology. This study investigates the microstructure, mechanical properties, and tribological performance of the coatings.
Tiantian He +5 more
doaj +1 more source
Failure analysis of automobile engine pump shaft bearing
Advances in Mechanical Engineering, 2021 The shaft bearing is the key component of water pump and its fatigue failure results in the abnormal operation of the system. However, the failure mechanisms of bearing are still unclear. In this paper, the failure analysis on the engine water pump shaft
Hao Guo +6 more
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source