Results 91 to 100 of about 1,178,203 (337)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tikrit Journal of Engineering Sciences, 2011 Finite element method is used to investigate the ultimate bearing capacity of rectangular footing resting on cohesive soil near slope. The effect of footing aspect ratio (L/B), distance ratio (b/B), and slope angle (β) on the bearing capacity are ...
Jawdat K. Abbas, Ayad S. Sabbar
doaj +1 more source
Bearing capacity of lunar surface materials [PDF]
Determining static mass bearing capacity of lunar surface by slope analysis of failed slopes in lunar ...
Martin, G. L.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Optimum parallel step-sector bearing lubricated with an incompressible fluid [PDF]
The dimensionless parameters normally associated with a step sector thrust bearing are the film thickness ratio, the dimensionless step location, the number of sectors, the radius ratio, and the angular extent of the lubrication feed groove.
Hamrock, B. J.
core +1 more source
Korelasi Penentuan Daya Dukung Tiang Cara Empirik (Cpt) Dengan Pile Driven Analysis (Pda) Di Kota Pekanbaru [PDF]
, 2007 Axial bearing capacity of pile foundation can be estimated empirically from cone penetration test (CPT). Actual capacity of foundation can be obtained from static load test or pile driving analyzer (PDA).
Nugroho, S. (SA), Yusa, M. (Muhamad)
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Experimental bearing capacity of eccentrically loaded foundation near a slope
Studia Geotechnica et Mechanica, 2019 Based on the response of small-scale model square footing, the present paper shows the results of an experimental bearing capacity of eccentrically loaded square footing, near a slope sand bed. To reach this aim, a steel model square footing of (150 mm ×
Mansouri Tarek, Abbeche Khelifa
doaj +1 more source
Study of the bearing capacity and settlement behavior of skirted foundations resting on cohesive soils [PDF]
, 2020 Sajjad Gholipour +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source