Results 71 to 80 of about 1,167,102 (307)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Experimental research and numerical simulation of bearing capacity of high-steep rock foundations near slopes

open access: yes矿业科学学报
This study conducted bearing capacity test of high-steep rock slope foundation under different slope angles and slope distances to investigate the bearing capacity of high-steep rock slope foundation.
LEI Yong   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

LONG BEARING CAPACITY OF WOODEN STRUCTURES

open access: yesStructural Mechanics of Engineering Constructions and Buildings, 2014
In the work, the solution of a problem of stability of the compressed wooden elements with taking into account nonlinear creep of wood is presented.
A S Varenik, K A Varenik
doaj  

Effect of Ellipsoidal Modulus and Internal Pressure on Bearing Capacity of Thrust-Bearing Aft Dome

open access: yesMATEC Web of Conferences, 2018
In order to analyse the effect of ellipsoidal modulus and internal pressure on bearing capacity of thrust-bearing aft dome, we obtain the stress and strain distribution and bearing capacity of 1.6, 1.4 and 1.0 modulus ellipsoidal aft dome under 0MPa~0 ...
Peng Wang   +4 more
doaj   +1 more source

Bearing capacity of lunar surface materials [PDF]

open access: yes
Determining static mass bearing capacity of lunar surface by slope analysis of failed slopes in lunar ...
Martin, G. L.
core   +1 more source

ANALYSIS OF FOOT PLATE FOUNDATION IN BUILDING ACADEMIC SERVICES SPORTS SCIENCE FACULTY YOGYAKARTA STATE UNIVERSITY [PDF]

open access: yes, 2012
This study aims to determine the bearing capacity of foundation soil that occurs in floot plate, knowing the decline of the foundation plate floot, can analyze the structure of a good foundation floot plate and check to see if the foundation is secure ...
Sudiharjo
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Shallow grooves in journal improve air bearing performance [PDF]

open access: yes, 1968
Bearing designs, which shape the surface to create artificial fluid-film wedges in the absence of any applied radial load, generate radial restoring forces to keep journals from whirling.
Anderson, W. J.   +2 more
core   +1 more source

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