Results 81 to 90 of about 1,167,102 (307)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Forecasting the bearing capacity of the mixed soil using artificial neural network
Fracture and Structural Integrity, 2020 The bearing capacity of soil changes owing to the mechanical properties of the soil and it influences the structural stability. In most of the geotechnical engineering projects, there are several soil mechanic experiments, that need interpretation before
Abdoullah Namdar
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Angular displacement indicating gas bearing support system Patent [PDF]
, 1971 Gas bearing for model support with capacity for measuring angular displacement of model in ...
Kersey, E. D., Jr.
core +1 more source
The vertical capacity of grillage foundations [PDF]
, 2011 Grillage foundations may provide an economical alternative to offshore ‘mudmat' foundations for seabed infrastructure, owing to their improved hydrodynamic characteristics, which are important during installation.
Bransby, M.F. +3 more
core +3 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Applied SciencesIn the marine environment, the suction caisson foundation (SCF) is often subjected to combined inclined and cyclic loading from wind and waves, which may significantly affect its ultimate bearing capacity. Under combined loading conditions, the evolution
Kang Huang +6 more
doaj +1 more source
Rolling-element fatigue life of silicon nitride balls: Preliminary test results [PDF]
Hot pressed silicon nitride was evaluated as a rolling element bearing material. The five-ball fatigue tester was used to test 12.7 mm (0.500 in.) diameter balls at a maximum Hertz stress of 800,000 psi at a race temperature of 130 F.
Parker, R. J., Zaretsky, E. V.
core +1 more source
Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody. [PDF]
, 2019 Breast cancers enduring treatment with chemotherapy may be enriched for cancer stem cells or tumor-initiating cells, which have an enhanced capacity for self-renewal, tumor initiation, and/or metastasis.
Carson, Dennis A +17 more
core +1 more source
The Bearing Capacity of Simulated Lunar Surfaces in Vacuum [PDF]
, 1963 The static bearing capacity of a granular material consisting of dry, crushed olivine basalt was determined in air and in a 10^(-6) mm Hg vacuum by means of cylindrical probes with a range of diameters.
Bernett, E. C. +4 more
core +2 more sources