Results 61 to 70 of about 4,493,317 (309)

Bearing Capacity of very Expansive Soils at Jatinangor Area, West Java, Indonesia

MATEC Web of Conferences, 2018
Expansive soil is a kind of soil that has ability to shrinkage and swelling. According to Ronny (2014) Jatinangor area has expansive soil that is so very influential in the planning of infrastructure construction.
Simangunsong David, Wibowo Satrio, Zakaria Zufialdi   +2 more
doaj   +1 more source

3D bearing capacity probabilistic analyses of footings on spatially variable c–φ soil

Acta Geotechnica, 2019
The paper examines three-dimensional (3D) analyses of the load bearing capacity of square and strip footings on a spatially variable cohesive–frictional (c–φ) soil. Embedded, rigid and smooth footings are considered.
M. Kawa, W. Puła
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Experimental research and numerical simulation of bearing capacity of high-steep rock foundations near slopes

矿业科学学报
This study conducted bearing capacity test of high-steep rock slope foundation under different slope angles and slope distances to investigate the bearing capacity of high-steep rock slope foundation.
LEI Yong, LIU Zikui, CHEN Yusi, HE Changjie, LI Jianxin   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

LONG BEARING CAPACITY OF WOODEN STRUCTURES

Structural Mechanics of Engineering Constructions and Buildings, 2014
In the work, the solution of a problem of stability of the compressed wooden elements with taking into account nonlinear creep of wood is presented.
A S Varenik, K A Varenik
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Undrained bearing capacity of spatially random soil for rectangular footings

Soils and Foundations, 2019
In this study, a new approach for the evaluation of the 3-D random bearing capacity in rectangular footings is described. The soil strength spatial variability is modelled by random fields.
M. Chwała
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source