Results 31 to 40 of about 266,064 (263)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Research on Bored Bearing Characteristics in Xi’an
MATEC Web of Conferences, 2015 To analyze the influence of different soil properties on pile foundation load-bearing characteristics, taking a section of railway in Xi’an and a bridge of Xi’an as test area, and by field static load test to study load transfer characteristics after the
Zhang Lipeng, Shen Yabin, Wang Duanduan
doaj +1 more source
Prediction of Ultimate Bearing Capacity of Long-Term Loaded Piles
Shanghai Jiaotong Daxue xuebao, 2021 To predict the ultimate bearing capacity of long-term loaded piles, the shortcomings of current empirical formulas of pile bearing capacity considering time effect are discussed.
LI Jingpei, XU Zihan
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Evaluation Of The Method Of Stress Characteristics For Estimation Of The Soil Bearing Capacity [PDF]
Engineering and Technology Journal, 2008 The classical bearing capacity theories rely on the superposition of three separatebearing capacities – a technique that is inherently conservative – but they also rely ontabulated or curve-fitted values of the bearing capacity factor, Nγ, which may ...
Mohammed Y. Fattah +2 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Bearing Capacity of Shallow Foundations
Soils and Foundations, 1997 ABSTRACT A new concept for the calculation of the bearing capacity of shallow foundations is presented. The Terzaghi-Buisman equation was transformed and extended to include all possible load cases. The shape ratio was rigorously defined. Torsional moment factors considering eccentric horizontal loads were proposed and defined for the first time, in ...
openaire +2 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source