Results 101 to 110 of about 1,309,062 (296)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
河南理工大学学报. 自然科学版Significance Post-grouting of pipe piles is an effective technique for improving the physical and mechanical properties of the pile-soil interface， playing a significant role in enhancing the frictional resistance of pipe piles and reducing settlement of
HOU Zhenkun +7 more
doaj +1 more source
DYNAMIC CHARACTERISTICS OF ROTOR-BEARING SYSTEM AND EVOLUTION OF BEARING WEAR (MT)
Jixie qiangdu, 2022 Taking the rotor system supported by angular contact ball bearing as the research object, the dynamic model of rotor bearing system is established by using Lagrange equation. Based on the Archard wear model, the calculation model of wear depth of bearing
WEI Lai +3 more
doaj
Dynamics of Multistage Gear Transmission with Effects of Gearbox Vibrations [PDF]
A comprehensive approach is presented in analyzing the dynamic behavior of multistage gear transmission systems with the effects of gearbox induced vibrations and mass imbalances of the rotor.
Choy, F. K. +3 more
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Performance of PTFE-lined composite journal bearings [PDF]
Plain cylindrical journal bearings consisting of aramid fiber reinforced epoxy outer shells and glass fiber reinforced PTFE lubricating liners were evaluated. All materials in these bearings are electrically nonconductive; thus eliminating the problem of
Sliney, H. E., Williams, F. J.
core +1 more source
Maximizing Minimum Pressure in Fluid Dynamic Bearings of Hard Disk Drives [PDF]
, 2007 We focus on the central spindle which supports the rotating magnetic platters which hold all of the data. The spindle must operate with great precision and stability at high rotational speeds.
Atena, Agegnehu +11 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Bearing tester data compilation, analysis and reporting and bearing math modeling, volume 1 [PDF]
Thermal and mechanical models of high speed angular contact ball bearings operating in LOX and LN2 were developed and verified with limited test data in an effort to further understand the parameters that determine or effect the SSME turbopump bearing ...
Marshall, D. D. +4 more
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source