Results 51 to 60 of about 1,605,223 (291)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Comprehensive Review of Bearing Currents in Electrical Machines: Mechanisms, Impacts, and Mitigation Techniques

open access: yesEnergies
The present paper deals with a review on bearing currents in electrical machines, with major emphasis on mechanisms, impacts, and mitigation strategies.
Tianyi Pei   +3 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Analysis of Traction Motor Bearing Voltage and Bearing Current Considering Whole-train Grounding and Suppression Measures

open access: yesChengshi guidao jiaotong yanjiu
Objective Most urban rail transit trains use PWM (pulse width modulation) variable frequency drive system, which often leads to bearing corrosion problems due to the excessive bearing voltage and bearing current during operation.
CHEN Zhi   +5 more
doaj   +1 more source

Novel Bearing Current Suppression Approach in Doubly-Fed Induction Generators

open access: yesIEEE Access, 2019
Doubly-fed induction generators (DFIGs) are widely used in the wind power generation systems. However, due to the use of the power electronic devices, such as insulated gate bipolar transistor (IGBT), it is inevitable to generate a non-zero common mode ...
Ruifang Liu   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Who pays for renewables? Increasing renewable subsidisation due to increased datacentre demand in Ireland. ESRI WP566, June 2017 [PDF]

open access: yes, 2017
Demand from datacentres makes up a rapidly growing portion of electricity demand in Ireland. Increased demand in turn gives rise to increased renewable generation, mandated by government targets, and a corresponding increase in subsidisation levels.
Devine, Mel T., Lynch, Muireann Á.
core  

Neutrino Interactions in Hot and Dense Matter [PDF]

open access: yes, 1997
We study the charged and neutral current weak interaction rates relevant for the determination of neutrino opacities in dense matter found in supernovae and neutron stars.
A. Burrows   +65 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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