Results 111 to 120 of about 185,293 (312)

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Impact of skin sensitivity mechanisms on sebum secretion: Management strategies for oily sensitive skin

Journal of Dermatologic Science and Cosmetic Technology
Recent epidemiological surveys based on Baumann's classification have revealed a notable rise in the prevalence of oily sensitive skin. The development of oily sensitive skin is primarily linked to the abnormal function of sebaceous glands.
Yijie Du, Xiaokai Li, Siqi Zhao, Xiaoyang Zheng, Wenyi Zhu, Jianhua Zhang, Hong Meng, Yinmao Dong   +7 more
doaj   +1 more source

Beauty Photoproduction at HERA II with the ZEUS Experiment.

, 2006
In this thesis the beauty photoproduction cross section has been measured with the ZEUS detector at HERA II using e+p data collected in 2004 corresponding to an integrated luminosity of 33 pb-1.
Miglioranzi, Silvia, Silvia Miglioranzi, Miglioranzi, S.   +2 more
core  

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Maximizing your learning potential: exploring motivation, self-directed learning, and smart media utilization in the digital age

Cogent Education
This study sought to explore the interaction between motivation and self-directed learning in the digital age and the use of smart media, where technology can play a role in promoting learning.
Jooyoung Lee
doaj   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Time-Series and Demographic Trends in Cosmetic Surgery: Multicenter Analysis of Double-eyelid Embedding in Japan

Plastic and Reconstructive Surgery, Global Open
Background:. The cosmetic surgery market has rapidly expanded owing to technological advancements and changes in aesthetic values. Minimally invasive procedures have gained substantial popularity among patients, with double-eyelid embedding being among ...
Kohki Okumura, MD, Takahiko Tamura, MD, PhD, Yusuke Funakoshi, MD, PhD, Hiroo Teranishi, MD   +3 more
doaj   +1 more source

Beauty is truth, truth beauty

BMJ, 2007
John Keats is perhaps better known for his Romantic poetry, such as Ode To A Grecian Urn , than for the fact that he trained as a surgeon-apothecary at Guy's Hospital, 1815-6. …
openaire   +2 more sources