Results 61 to 70 of about 561,283 (308)

Slathered, Zapped, Nipped, and Tucked: An Ethical Analysis of Cosmetic Dermatology [PDF]

, 2017
It has become common practice for dermatologists to offer cosmetic enhancing products and procedures and to do so alongside the medically required services offered (e.g., annual skin checks, treatment of rashes, removal of pre-cancerous moles, etc.).
Lowe, Barbara
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

On the universality of aesthetic preference and inference: a cross-cultural (Chinese–German) study

Humanities & Social Sciences Communications
Aesthetic preferences vary widely among individuals and across cultures. These culture-specific aesthetic preferences are reflected in the environment, artistic behaviour, and consumer choices.
Chantal A. Miller, Keshun Zhang, Ronald Hübner   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Traditional Metaphors of Indonesian Women’s Beauty

Open Cultural Studies
The aim of this article is to elaborate on the problem of traditional metaphors used to describe the beauty of Indonesian women. The traditional metaphors used to describe the beauty of Indonesian women originate from nature and show specific aspects of ...
Saidi Acep Iwan, Puspitasari Dyah Gayatri, Parung Christabel Annora Paramita, Luzar Laura Christina   +3 more
doaj   +1 more source

Central Javanese Adaptation To The Islamic Concept Of Aesthetics [PDF]

, 2006
In addition to politics, economics, sociology, and theology, aesthetics as the study of beauty is proposed as a legitimate approach to Islamic cultures.
Duffort, Sulaiman
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Transnational Chinese Beautyscapes: Ghetto Glamour and Fake Beauty in Abidjan

Africa Spectrum
This article explores how beauty and fashion practices and imagination have evolved in Ivory Coast since the early 2000s, using secondary sources and ethnographic research conducted in Abidjan in 2017. In addition to identifying alternatives to prevalent
Basile Ndjio
doaj   +1 more source

Iklan Dan Budaya Popular: Pembentukan Identitas Ideologis Kecantikan Perempuan Oleh Iklan (Analisis Semiotika Iklan Cetak WRP Body Shape & Prolene) [PDF]

, 2005
Mass media is not only a channel to deliver messages but also is a channel to build a special image about the world, such as the beauty image of women. Advertisements create it in their messages.
Aprilia, D. R. (Dwi)
core