Results 51 to 60 of about 680 (206)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Nefertiti not Beautiful? [PDF]

open access: yesمجلة کلية الآثار - جامعة القاهرة
The famous bust of Nefertiti in Berlin is hailed for showing her marvelous beauty which stands in hard contrast to the reputation of the Amarna art of showing a caricature-like exaggerated realism, that has even been described as deliberately depicting ...
Tarek . S. Tawfik
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Negotiating beauty in Pakistan: A qualitative exploration of body image, nutrition, and cultural ideals among young women in Azad Jammu & Kashmir

open access: yesDialogues in Health
Beauty is not a static or universal phenomenon. However, it is a dynamic ideal shaped by sociocultural patterns and practices. Particulalry, multiple sociocultural patterns prevail regarding how a female body should be maintained, displayed, and ...
Sajal Bint-e-Khalil, Inayat Ali
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Senses of body image in adolescents in elementary school

open access: yesRevista de Saúde Pública, 2014
OBJECTIVE : To comprehend the perception of body image in adolescence. METHODS : A qualitative study was conducted with eight focus groups with 96 students of both sexes attending four public elementary school institutions in the city of Rio de ...
Maria Lídia de Abreu Silva   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Fantasies and Fallacies of ‘Aesthetic’ Instagrammers

open access: yesIndian Journal of Plastic Surgery
The influence of Instagram, as a social media platform, in shaping perceptions of aesthetic surgery cannot be understated. The idea of a more “aesthetic” self cultivates a desire for cosmetic enhancements.
Mrigya Sharma   +2 more
doaj   +1 more source

Occidentalisation of Beauty Standards: Eurocentrism in Asia

open access: yes, 2020
Beauty standards have long been set in place within society. However the origins of such beauty standards are a topic of discussion and frequently up for debate. Our paper takes a look into the origins, impacts, and implications of beauty standards within various regions of Asia, including Central Asian, South Asia, East Asia, and the Middle East and ...
Chen, Toby   +4 more
openaire   +2 more sources

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