Results 81 to 90 of about 14,223 (291)
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
“Best Before”: On Women, Ageism, and Mental Health
Mental HealthIntroduction: Our world has changed over the last decades, and one of the dramatic changes has been the increase in human life expectancy. Due to important life-saving breakthroughs, the current life expectancy for the world in 2024 is 73.33 years; and ...
Danylova Tetiana +6 more
doaj +1 more source
Aesthetic Transcendence: Fashion's Evolution, Philosophical Reflections, and Societal Impact
Journal of Current Social and Political IssuesThis research paper explores the evolution of fashion from its utilitarian origins over 170,000 years ago to its contemporary role as a symbol of cultural expression and individual identity. Tracing the historical trajectory through ancient civilizations,
Ankita Sharma
doaj +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Representation of American Women’s Beauty Standards through Beauty Pageants [PDF]
This study aims to determine the representation of American women's beauty standards through beauty pageants in the America such as Miss USA, Miss Teen USA, and Miss Muslimah USA.
Nurhasanah, Siti
core
Female body perception: social norms, criticism, and the impact of weight perception
International Journal of Qualitative Studies on Health & Well-BeingPurpose This study aims to explore the multifaceted nature of women's body perception and the personal and social factors that influence it. The research investigates how societal expectations, health concerns, and self-perception intersect in shaping ...
Reşat Sadık, Gizem Nur Yılmaz
doaj +1 more source
Галактика медиа: журнал медиа исследованийThe fear of aging and the loss of beauty is a pervasive societal issue that transcends cultural boundaries, often manifesting in the media and film industry. This paper examines the 2010 animated film “Tangled” and an Indian Film “Yashoda” (2022) through
Bhuvaneswari Gopalakrishnan +2 more
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Lived Experiences of Filipinas in Adhering to the Beauty Standards in TikTok
, 2021 Deeply rooted in a Filipina\u27s grip of oneself was the reflection of what her detractors claim to know about her. However, as she had grown to know better, her reigning beauty eventually became the fairest of them all.
Mariano, Jalwinder Kate G. +6 more
core +1 more source