Results 141 to 150 of about 24,253,925 (274)

Human cachexia induces changes in mitochondria, autophagy and apoptosis in the skeletal muscle [PDF]

, 2019
Cachexia is a wasting syndrome characterized by the continuous loss of skeletal muscle mass due to imbalance between protein synthesis and degradation, which is related with poor prognosis and compromised quality of life.
Alcantara, P. S., Coletti, D., de Castro, G. S., Festuccia, W. T., Lima, J. D. C. C., Ortiz-Silva, M., Otoch, J. P., Seelaender, M., Simoes, E., Tokeshi, F.   +9 more
core   +1 more source

Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex

Cell Death and Differentiation, 2020
Necroptosis is a form of regulated cell death caused by formation of the necrosome complex. However, the factors modulating this process and the systemic pathophysiological effects of necroptosis are yet to be understood.
Jinho Seo, D. Seong, Young Woo Nam, Chi Hyun Hwang, Seung Ri Lee, Choong-Sil Lee, Young-June Jin, Han-Woong Lee, D. Oh, P. Vandenabeele, Jaewhan Song   +10 more
semanticscholar   +1 more source

Genotypic Variation and Association Mapping for Plant Stature and Anthesis‐Silking Interval in Set of Temperate‐Adapted Maize Lines Developed by DH and SSD Methods

Plant Breeding, EarlyView.
ABSTRACT BS39 is a broad‐based population of tropical maize adapted to temperate environments that can provide useful and unique alleles to US Corn Belt breeding programmes. Doubled‐haploid (DH) has been used as an efficient alternative method to speed up the development of maize lines. Our objectives were to compare genetic parameters for plant height
Gabriela dos Santos Pereira, Iara Gonçalves dos Santos, Nathalia Campos Vilela Resende, Anderson Luiz Verzegnazzi, Ursula K. Frei, Rodrigo Oliveira DeLima, Thomas Lübberstedt   +6 more
wiley   +1 more source

Prognostic and clinicopathological value of Beclin-1 expression in hepatocellular carcinoma: a meta-analysis

World Journal of Surgical Oncology, 2018
Background The abnormal expression of Beclin-1 has recently been investigated in a variety of tumors. However, previous studies have obtained contradicting results regarding the clinical and prognostic value of Beclin-1 in hepatocellular carcinoma (HCC).
Zhiqiang Qin, Xinjuan Yu, Mei Lin, Jinkun Wu, Shupei Ma, Ning Wang   +5 more
doaj   +1 more source

Autophagy in Microglia and Alzheimer's disease [PDF]

, 2019
Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by amyloid-beta plaques, neurofibrillary tangles and neuroinflammation. Autophagy has been associated with several neurodegenerative diseases.
Houtman, Judith
core   +1 more source

The Roles of Beclin 1 Expression in Gastric Cancer: A Marker for Carcinogenesis, Aggressive Behaviors and Favorable Prognosis, and a Target of Gene Therapy

Frontiers in Oncology, 2020
Beclin 1 is encoded by Becn1, and plays a role in tumorigenesis, neurodegeneration, apoptosis and autophagy. Here, the aggressive phenotypes and relevant proteins were examined after Beclin 1 expression was altered in gastric cancer cells.
Hua-Chuan Zheng, Shuang Zhao, H. Xue, Enhong Zhao, Hua-Mao Jiang, Chang-lai Hao   +5 more
semanticscholar   +1 more source

Harnessing blue light photobiomodulation for cancer therapy: Evidence from a systematic review

Photochemistry and Photobiology, EarlyView.
Conventional treatments for various types of cancer are often associated with tumor recurrence and aggressiveness. Photobiomodulation with blue light (BL; 450–470 nm) emerges as a promising alternative with antitumor effects. This systematic review, with 37 in vitro and in vivo studies from 2002 to 2024, revealed that BL reduces cell viability ...
Bárbara Evelyn Santos de Lima, Rebeca Barros Nascimento, Ana Paula Mariano Santos Ginez, Maria Stella Moreira, Rebeca Boltes Cecatto, Rodrigo Labat Marcos, Maria Fernanda Setúbal Destro Rodrigues   +6 more
wiley   +1 more source

Beclin 1

, 2012
Fil: Molejon, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas.
Molejon, Maria Ines, Ropolo, Alejandro Javier, Vaccaro, Maria Ines   +2 more
openaire   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury

Neurobiology of Disease, 2008
Autophagy, an intracellular bulk degradation process of cellular constituents, plays a key role in cell homeostasis and can be induced by stresses, such as nutrient depletion, closed head injury or focal cerebral ischemia.
Silvia Carloni, Giuseppe Buonocore, Walter Balduini   +2 more
doaj   +1 more source