Results 81 to 90 of about 31,069 (166)

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, Volume 13, Issue 32, 9 June 2026.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

Advanced Science, Volume 13, Issue 33, 15 June 2026.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang, Wei‐Tong Chen, Yu‐Ying Shen, Zhao‐Yang Wang, Kai Li, Xueli Zhao, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Bacterial Pigments as Potential Antitumor Agents Against Gastrointestinal Cancers: A Comprehensive Systematic Review

Biotechnology and Applied Biochemistry, Volume 73, Issue 3, Page 1626-1646, June 2026.
ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara, Ricardo F. S. Pereira, Carla C. C. R. de Carvalho, Jose Prados, Consolación Melguizo, Raul Ortiz   +5 more
wiley   +1 more source

New Insights Into the Role of Neutrophils in Lymphoma

Cancer Medicine, Volume 15, Issue 6, June 2026.
Tissue‐resident neutrophils challenge conventional paradigms by actively infiltrating normal lymphoid organs, predominantly localizing in interstitial compartments, a spatial distribution distinct from their classical vascular positioning. Neutrophils in lymphoid organs exhibit unique phenotypic and functional signatures, suggesting they play roles in ...
Ling Gu
wiley   +1 more source

Stress reduction through cortical bone thickening improves bone mechanical behavior in adult female Beclin-1+/− mice

Frontiers in Bioengineering and Biotechnology
Fragility fractures, which are more prevalent in women, may be significantly influenced by autophagy due to altered bone turnover. As an essential mediator of autophagy, Beclin-1 modulates bone homeostasis by regulating osteoclast and chondrocyte ...
Jiaojiao Yang, Jiaojiao Yang, Qilin Pei, Qilin Pei, Xingfan Wu, Xin Dai, Xi Li, Jun Pan, Bin Wang   +8 more
doaj   +1 more source

USP5‐C‐MAF Axis Regulates Autophagy‐Dependent Neuronal Ferroptosis in Spinal Cord Injury Therapeutics

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
SCI induces significant upregulation of USP5 in neurons. The overexpressed USP5 stabilizes c‐MAF protein expression through its deubiquitinase activity, activating autophagy and accelerating the degradation of autophagic ferritin, thereby mediating neuronal ferroptosis. This ultimately leads to impaired functional recovery in SCI mice.
Shiyang Weng, Kai Wu, Yinjun Huang, Lei Cao, Huichao Fu   +4 more
wiley   +1 more source

Immunohistochemical and bioinformatics analysis of the placental BCL-2 and Beclin-1 expressions in preeclampsia and HELLP syndrome

Journal of Obstetrics and Gynaecology
Background This study aimed to examine the alterations in apoptosis and autophagy in placental tissues from normal pregnancies compared to those affected by preeclampsia (PE) and HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome.
Süleyman Cemil Oğlak, Fırat Aşır, Emine Zeynep Yılmaz, Ayşegül Aşır, Gökhan Bolluk, Tuğcan Korak, Hayat Ayaz, Elif Ağaçayak   +7 more
doaj   +1 more source

High‐Altitude Hypoxia Activates JNK‐p53 Signaling: Linking Hippocampal Energy Crisis to Cognitive Impairment

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Chronic high‐altitude hypoxia impairs memory in 2819 residents and causes hippocampal atrophy in rats. JNK‐p53‐Bim signaling drives mitophagy‐to‐apoptosis transition and 73% ATP depletion, while concurrent HIF‐2α/PHD2 activation indicates parallel adaptive responses.
Guisheng Hao, Zhengzhong Bai, Wenjuan Wang, Jian Wu, Fan Zheng, Guoen Jin, Ri‐Li Ge   +6 more
wiley   +1 more source

Glutathione peroxidase 3 preserves hepatocyte mitochondrial quality control to enhance macrophage pro‐regenerative phenotype during liver regeneration

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
(1) GPX3 inhibits VDAC1 oligomerisation by directly binding to it. (2) The loss of GPX3 leads to VDAC1 oligomerisation, resulting in dysregulation of mitochondrial quality control, characterised by enhanced fission, weakened fusion and impaired autophagy.
Yuechen Wang, Jian Xu, Zeyu Zhu, Ye Zhang, Haoran Hu, Yiyun Gao, Yuting Tao, Feifan Yao, Suiqing Zhou, Weizhe Zhong, Zhuqing Rao, Haoming Zhou, Xuehao Wang   +12 more
wiley   +1 more source