Results 251 to 260 of about 27,302,953 (278)

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.

Cell, 2005
S. Pattingre, Amina T Tassa, X. Qu, R. Garuti, X. H. Liang, N. Mizushima, M. Packer, M. Schneider, B. Levine   +8 more
semanticscholar   +3 more sources

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Nature, 1999
X. H. Liang, Saadiya Jackson, M. Seaman, K. Brown, B. Kempkes, H. Hibshoosh, B. Levine   +6 more
semanticscholar   +3 more sources

Kinase crosstalk through beclin 1

Nature Reviews Molecular Cell Biology, 2013
Katharine H Wrighton
openaire   +3 more sources

Beclin 1, Bcl-2 and Autophagy.

Advances in Experimental Medicine and Biology, 2019
Beclin 1 is the first mammalian autophagy protein identified as a novel Bcl-2-interacting protein. Subsequent studies have demonstrated that this landmark protein is essential for autophagy. By investigating the interaction between Bcl-2 and Beclin 1, key molecular mechanisms of mammalian autophagy regulation have been discovered.
Hai-dong Xu, Zheng-Hong Qin
semanticscholar   +3 more sources

Luteolin inhibits autophagy in allergic asthma by activating PI3K/Akt/mTOR signaling and inhibiting Beclin-1-PI3KC3 complex.

International Immunopharmacology, 2021
Allergic asthma is a common chronic inflammatory disease characterized by airway inflammation, mucus hypersecretion and airway remodeling. Autophagy is a highly conserved intracellular degradation pathway in eukaryotic cells.
Shiyuan Wang, Tulake Wuniqiemu, Weifeng Tang, Fangzhou Teng, Qin Bian, La Yi, Jingjing Qin, Xueyi Zhu, Ying Wei, Jingcheng Dong   +9 more
semanticscholar   +1 more source

Beclin-1 and LC3A expression in cutaneous malignant melanomas

Melanoma Research, 2011
Autophagy is an intracellular pathway for the degradation of long-lived proteins and damaged organelles. It is, in essence, a recycling process allowing cells to survive oxygen and nutrient depletion. The expression of two autophagy-related proteins, beclin 1 and light chain 3A (LC3A) was investigated in 79 nodular cutaneous melanomas. The results were
Efthimios, Sivridis, Michael I, Koukourakis, Savvas E, Mendrinos, Antonios, Karpouzis, Aliki, Fiska, Constantinos, Kouskoukis, Alexandra, Giatromanolaki   +6 more
openaire   +2 more sources

The beclin 1 interactome: Modification and roles in the pathology of autophagy-related disorders.

Biochimie, 2020
Beclin 1 a yeast Atg6/VPS30 orthologue has a significant role in autophagy process (Macroautophagy) and protein sorting. The function of beclin 1 depends on the interaction with several autophagy-related genes (Atgs) and other proteins during the ...
Sargeet Kaur, H. Changotra
semanticscholar   +1 more source

Beclin 1 Complex and Neurodegenerative Disorders

2020
Beclin1 is the mammalian orthologue of yeast Atg6/vacuolar protein sorting-30 (VPS30). Beclin1 interacts with various biological macromolecules like ATG14, BIF-1, NRBF2, RUBICON, UVRAG, AMBRA1, HMGB1, PINK1, and PARKIN. Such interactions promote Beclin1-PI3KC3 complex formation.
Ozaifa Kareem, Ghulam Nabi Bader, Faheem Hyder Pottoo, Mohd. Amir, Md. Abul Barkat, Mukesh Pandey   +5 more
openaire   +1 more source

Beclin 1-ATG14L Protein-Protein Interaction Inhibitor Selectively Inhibits Autophagy through Disruption of VPS34 Complex I.

Journal of the American Chemical Society, 2020
Autophagy, a catabolic recycling process, has been implicated as a critical pathway in cancer. Its role in maintaining cellular homeostasis helps to nourish hypoxic, nutrient-starved tumors and protects them from chemotherapy-induced death.
I. Pavlinov, M. Salkovski, L. Aldrich
semanticscholar   +1 more source

Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy.

Life Science, 2020
AIMS Hsp90 is regarded as an important therapeutic target in cancer treatment. Client proteins of Hsp90 like Beclin-1, PI3K, and AKT, are associated with tumor development, poor prognosis, and resistance to cancer therapies.
Adria Hasan, E. Haque, R. Hameed, P. Maier, S. Irfan, Mohd Kamil, A. Nazir, S. Mir   +7 more
semanticscholar   +1 more source