Results 91 to 100 of about 5,752,788 (339)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Becoming a teacher educator : guidelines for induction : 2nd edition [PDF]
, 2011 The first edition of these guidelines was published in 2007. Since that date it has been used to support the induction of new teacher educators in the UK and beyond.
Boyd, Pete, Harris, Kim, Murray, Jean
core +1 more source
Affective Embodiment and the Transmission of Affect in Ex Machina
Philosophies, 2019 The focus of posthuman thought centers on a shift in the humanistic paradigm; focusing on a state of existence that lies beyond being “human”, including bioengineering, artificial intelligence, and synthetic embodiment. Inspired by continuous
Chia Wei Fahn
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
A macroprolactinoma becoming resistant to cabergoline and developing atypical pathology [PDF]
, 2016 Pituitary adenomas are a common intracranial neoplasm, usually demonstrating a benign phenotype. They can be classified according to pathological, radiological or clinical behaviour as typical, atypical or carcinomas, invasive or noninvasive, and ...
Ansorge, Olaf +6 more
core +3 more sources
How do data come to matter? Living and becoming with personal data
Big Data & Society, 2018 Humans have become increasingly datafied with the use of digital technologies that generate information with and about their bodies and everyday lives.
Deborah Lupton
semanticscholar +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Becoming more systematic about flexible learning: beyond time and distance [PDF]
, 2005 Changes in higher education frequently involve the need for more flexibility in course design and delivery. Flexibility is a concept that can be operationalized in many ways.
Boer, Wim de, Collis, Betty
core +6 more sources
Languaging the Borders of Europe
Social Sciences, 2015 Emerging from a discomfort with the blind spots encountered within and across theorizations of language and space in the field of human geography, in this article, we argue for “making space” for conceptualizations that speak from and through the ...
Olivier Kramsch, Kolar Aparna, Huda Degu
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source